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Ruxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.73 mL | 123.63 mL | 247.26 mL |
| 0.5 mM | 4.95 mL | 24.73 mL | 49.45 mL |
| 1 mM | 2.47 mL | 12.36 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
*The above data is based on the productmolecular weight 404.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11467 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 404.44 |
| Formula | C17H20N6O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1092939-16-6 |
| Synonyms | INCB018424 sulfate, INCB 018424, INCB-018424 |
| SMILES | [H][C@@](C1CCCC1)(N2N=CC(C3=C4C=CNC4=NC=N3)=C2)CC#N.O=S(O)(O)=O |
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