Interleukin-1 receptor-associated kinases (IRAKs) are key components in the signal transduction pathways utilized by interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R), and Toll-like receptors (TLRs).

6 个项目


  1. JNK-IN-7

    Catalog No. A15136
    JNK Inhibitor
    JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C. 了解更多
  2. IRAK-1-4 Inhibitor I

    Catalog No. A11462
    IRAK-1-4 inhibitor is a benzimidazole that disrupts the activity of IRAK-1 and -4 with IC50 values of 300 and 200 nM, respectively. 了解更多
  3. IRAK inhibitor 6 (IRAK-IN-6)

    Catalog No. A11460
    IRAK inhibitor
    IRAK-IN-6, also known as IRAK inhibitor 6, is an interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor. IRAK-4 is reported to be essential for the activation of the intracellular signalling cascades including NF-kB and MAPK pathways, which are critical for the production of inflammatory cytokines. 了解更多
  4. CA-4948

    Catalog No. A17005
    IRAK4 inhibitor
    CA-4948是一种有效的口服活性白细胞介素-1受体相关激酶4(IRAK4)抑制剂。 与GBC-DLBCL和ABC / GCB DLBCL PDX模型相比,CA-4948在测试的五种ABC-DLBCL PDX模型中的四种中表现出最大功效。 了解更多
  5. PF-06650833

    Catalog No. A17187
    IRAK4 inhibitor
    PF-06650833是白细胞介素-1受体相关激酶4(IRAK4)的抑制剂。 了解更多
  6. AS 2444697

    Catalog No. A17186
    IRAK4 inhibitor
    AS-2444697是一种有效的选择性白细胞介素-1受体相关激酶4(IRAK4)抑制剂,IC50值为21 nM。 了解更多

6 个项目