mAChR

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  1. Metanicotine

    Catalog No. A11545
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    Nicotinic receptor 激动剂
    Metanicotine是一种神经元的尼古丁受体激动剂,对α4β2亚型具有高选择性(Ki = 26 nM)。选择性是α7受体(Ki = 36000 nM)的1,000倍以上。 了解更多
  2. BQCA

    Catalog No. A17156
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    BQCA是M1毒蕈碱乙酰胆碱受体(mAChR)的高度选择性正变构调节剂。 了解更多
  3. Arecoline

    Catalog No. A13071
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    Arecoline是槟榔籽中的胆碱能生物碱。 了解更多
  4. Oxybutynin

    Catalog No. A10684
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    Oxybutynin (Ditropan)是一种抗胆碱能药物,是一种竞争性的muscarinic acetylcholine receptorM1,M2,和M3拮抗剂,用于缓解尿道和膀胱疾病。 了解更多
  5. Methscopolamine bromide

    Catalog No. A10579
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    Methscopolamine bromide是一种竞争性抗毒蕈碱剂,可阻断乙酰胆碱与毒蕈碱型乙酰胆碱受体(mAChR M)的结合。 了解更多
  6. Ipratropium bromide

    Catalog No. A10476
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    Ipratropium bromide是毒蕈碱拮抗剂、支气管扩张剂、阿托品的N-异丙基盐。 了解更多
  7. Gallamine triethiodide

    Catalog No. A10417
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    mAChR M2 拮抗剂
    Gallamine Triethiodide是一种具有显著心脏选择性的mAChR M2拮抗剂。 了解更多
  8. Darifenacin

    Catalog No. A11987
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    Darifenacin通过阻断M3毒蕈碱型乙酰胆碱受体而起作用,该受体主要负责膀胱肌肉的收缩。 了解更多
  9. Irsogladine

    Catalog No. A10480
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    Rsogladine是一种抗胃溃疡药,通过M1毒蕈碱乙酰胆碱受体结合促进细胞间的缝隙连接通讯。 了解更多
  10. Methoctramine hydrate

    Catalog No. A11975
    Methoctramine hydrate是nM浓度的选择性M2毒蕈碱受体拮抗剂。 了解更多
  11. Bethanechol chloride

    Catalog No. A10180
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    Muscarinic receptor 激动剂
    Bethanechol chloride是拟副交感神经的胆碱氨基甲酸酯,可选择性刺激毒蕈碱受体,而不会对烟碱样受体产生任何影响。 了解更多
  12. Orphenadrine citrate

    Catalog No. A11712
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    NMDA receptor 拮抗剂
    Orphenadrine柠檬酸盐是NMDA受体拮抗剂,Ki为6.0μM,还是HERG钾离子通道阻断剂。 了解更多
  13. Tropicamide

    Catalog No. A11706
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    Tropicamide是一种抗胆碱药,用作散瞳剂。 了解更多
  14. SVT-40776 (Tarafenacin)

    Catalog No. A10808
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    muscarinic receptor 拮抗剂
    SVT-40776 (Tarafenacin)是新型M3毒蕈碱受体拮抗剂,用于治疗膀胱过度活动症。 了解更多
  15. Atropine

    Catalog No. A10098
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    mAChR 拮抗剂
    Atropine是M1,M2,M3,M4和M5型毒蕈碱乙酰胆碱受体的竞争性拮抗剂。 了解更多
  16. Solifenacin succinate

    Catalog No. A11215
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    muscarinic M3 receptor antagoinst
    Solifenacin succinate是毒蕈碱M3受体拮抗剂,用于治疗尿失禁。 了解更多
  17. Tolterodine tartrate (Detrol LA)

    Catalog No. A10937
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    muscarinic receptor 拮抗剂
    Tolterodine tartrate (Detrol LA)是毒蕈碱受体拮抗剂。 了解更多
  18. Biperiden HCl

    Catalog No. A10147
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    Muscarinic receptor antagonist
    Biperiden HCl是毒蕈碱受体拮抗剂,对M1亚型表现出一定的选择性。 了解更多
  19. Rocuronium bromide

    Catalog No. A10803
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    AchR 拮抗剂
    Rocuronium Bromide是一种竞争性AchR拮抗剂,用于现代麻醉中。 了解更多
  20. Fesoterodine fumarate (Toviaz)

    Catalog No. A10386
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    AChR 拮抗剂
    Fesoterodine fumarate是一种用于尿急的药物,可减少尿液通过的频率并促使尿失禁。 了解更多
  21. 5-hydroxymethyl tolterodine (PNU 200577)

    Catalog No. A11166
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    muscarinic receptor 拮抗剂
    5-hydroxymethyl tolterodine (PNU 200577)是托特罗定的代谢产物,tolterodine是一种用于治疗尿失禁的毒蕈碱受体拮抗剂。 了解更多
  22. TBPB

    Catalog No. A14205
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    M1 mAChR 激动剂
    TBPB是一种变构M1 mAChR激动剂,EC50值为89 nM,可调节淀粉样蛋白加工并在大鼠中产生类抗精神病药活性。 了解更多
  23. Revefenacin

    Catalog No. A15986
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    muscarinic receptor 拮抗剂
    Revefenacin是正在研发中的有效,选择性毒蕈碱受体拮抗剂,可用于治疗COPD。 了解更多
  24. Glycopyrrolate

    Catalog No. A12641
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    muscarinic 拮抗剂
    Glycopyrrolate是一种毒蕈碱竞争性拮抗剂,可用作解痉挛药。 了解更多
  25. Flavoxate

    Catalog No. A12900
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    muscarinic AChR antagonist
    Flavoxate结合并抑制毒蕈碱受体,从而通过改变脑干的排尿中心来抑制排尿反射并增加膀胱容量。 了解更多
  26. Acetylcholine iodide

    Catalog No. A16390
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    Acetylcholine iodide是一种神经递质,存在于神经肌肉接头,植物神经节,副交感神经效应接头,交感神经效应接头的子集以及中枢神经系统的许多部位。 了解更多
  27. Atropine methyl bromide

    Catalog No. A18026
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    mAChR antagonist
    Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine. 了解更多
  28. Cevimeline hydrochloride

    Catalog No. A18092
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    mAChR agonist
    Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome. 了解更多
  29. Anisodamine

    Catalog No. A18215
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    alpha-1 adrenergic receptors / mAChRs inhibitor
    Anisodamine is an inhibitor of alpha-1 adrenergic receptors and mAChRs isolated from Chinese solanacea plant. 了解更多
  30. Cimetropium Bromide

    Catalog No. A18290
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    mAChR antagonist
    Cimetropium Bromide (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome. 了解更多
  31. Darenzepine

    Catalog No. A12333
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    muscarinic receptor inhibitor
    Darenzepine is a muscarinic receptor inhibitor extracted from patent US 20170095465 A1. 了解更多
  32. Tiotropium Bromide

    Catalog No. A10934
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    muscarinic acetylcholine receptor (mAChR) antagonist
    Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. 了解更多
  33. (-)-Nicotine ditartrate

    Catalog No. A13761
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    (-)-Nicotine ditartrate是AChR(烟碱乙酰胆碱受体)的有效激动剂。 了解更多
  34. Imidafenacin

    Catalog No. A15490
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    M3 receptors 抑制剂
    Imidafenacin是一种有效的选择性M3受体抑制剂,Kb为0.317 nM。对M2受体的效力较低(IC50 = 4.13 nM)。 了解更多
  35. Umeclidinium bromide

    Catalog No. A15268
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    Muscarinic receptor 拮抗剂
    Umeclidinium bromide (GSK573719A)是毒蕈碱受体拮抗剂,可用于治疗慢性阻塞性肺疾病(COPD)。 了解更多
  36. Cevimeline hydrochloride hemihydrate

    Catalog No. A15042
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    M1 激动剂
    Cevimeline hydrochloride hemihydrate是一种新型毒蕈碱受体激动剂,是干燥综合征干燥症的候选治疗药物。 了解更多
  37. PF-3635659

    Catalog No. A13548
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    muscarinic M(3) receptor 拮抗剂
    PF-3635659是有效的毒蕈碱M3受体拮抗剂。 了解更多
  38. Xanomeline oxalate

    Catalog No. A13685
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    mAChR 激动剂
    Xanomeline oxalate是毒蕈碱型乙酰胆碱受体的有效激动剂(M1,M2,M3,M4和M5的EC50值分别为0.3、92.5、5、52和42 nM)。 了解更多
  39. AF-DX 384

    Catalog No. A13856
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    mAChR 拮抗剂
    AF-DX 384是充当毒蕈碱乙酰胆碱受体的选择性拮抗剂的药物。 了解更多
  40. Nitenpyram

    Catalog No. A14229
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    AchR 激动剂
    Nitenpyram是一种烟碱乙酰胆碱受体(AchR)激动剂。 了解更多
  41. Diphenidol HCl

    Catalog No. A14244
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    M2/M3 拮抗剂
    Diphenidol HCl是毒蕈碱M2和M3受体的有效拮抗剂,pKb为6.72和7.02。 了解更多
  42. LY2119620

    Catalog No. A14217
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    M2/M4 AChR 激动剂
    LY2119620是人M2和M4毒蕈碱乙酰胆碱受体的特异性变构激动剂。 了解更多
  43. Catharanthine sulfate

    Catalog No. A12161
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    Catharanthine sulfate是长春碱型生物碱前体,具有抗肿瘤活性。它通过离子通道阻断和脱敏来抑制AChR。 了解更多
  44. MK7622

    Catalog No. A12835
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    M1 调节剂
    MK7622是毒蕈碱M1受体阳性变构调节剂。 了解更多

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