Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

MK-2206 2HCl

促销

AKT 抑制剂

0 Customer Reviews
产品目录号: A10003

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MK-2206 5mg A10003-5
¥ 600.00
MK-2206 10mg A10003-10
¥ 1,000.00
MK-2206 25mg A10003-25
¥ 1,500.00
MK-2206 50mg A10003-50
¥ 2,500.00
MK-2206 2HCl 10mM * 1mL in DMSO A10003-10mM-D
¥ 1,170.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.

MK-2206 2HCl

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MK-2206 2HCl 发表的文献 (10)
  • Nishihama K, .et al. Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus, Metabolism, 2018, May;82:88-99 PMID: 29366755
  • J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
  • Joo Sang Lee, .et al. Harnessing synthetic lethality to predict the response to cancer treatment, Nat Commun, 2018, 9: 2546 PMID: 29959327
  • Wan-Ting Hu, .et al. The O-glycosylating enzyme GALNT2 suppresses the malignancy of gastric adenocarcinoma by reducing EGFR activities, Am J Cancer Res, 2018, 8(9): 1739每1751 PMID: 30323967
  • Angela M. Gocher, .et al. Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells, J Biol Chem, 2017, Aug 25; 292(34): 14188每14204 PMID: 28634229
  • Kusuyama J, .et al. Constitutive activation of p46JNK2 is indispensable for C/EBP汛 induction in the initial stage of adipogenic differentiation, Biochem J, 2017, Oct 5;474(20):3421-3437 PMID: 28887384
  • Pi-Lin Sung, .et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036每4047 PMID: 26716408
  • Mika?l M. Martino, .et al. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration, Nat Commun, 2016, 7: 11051 PMID: 27001940
  • Dominik Schulz, .et al. HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances, Am J Cancer Res, 2016, 6(9): 1963每1975 PMID: 27725902
  • Jewett KA, .et al. The tumor suppressor p53 guides GluA1 homeostasis through Nedd4-2 during chronic elevation of neuronal activity., J Neurochem., 2015, Oct;135(2):226-33 PMID: 26250624

Chemical Information

目录号 A10003
Mechanism of action Inhibitor
分子量 480.4
化学分子式 C25H21N5O.2HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1032350-13-2
Synonyms MK2206
SMILES code C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl
化学名称 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride

生物活性

Description
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.
Targets
Akt1 (Cell-free assay) Akt2 (Cell-free assay) Akt3 (Cell-free assay)
8 nM12 nM65 nM

溶解性

Solubility (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.82 mL 104.08 mL 208.16mL
0.5 mM 4.16 mL 20.82 mL 41.63 mL
1 mM 2.08 mL 10.41 mL 20.82 mL
5 mM 0.42 mL 2.08 mL 4.16 mL

*The above data is based on the productmolecular weight 480.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

View Related Products By Research Topics

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

其他人对该产品使用了下列标签:

使用空格分隔标签。使用单引号(')标注词组。

Similar product(s)


Keywords:购买 MK-2206 2HCl | MK-2206 2HCl 供应商 | 订购 MK-2206 2HCl | MK-2206 2HCl 价格 | MK-2206 2HCl 生产商 | 订单 MK-2206 2HCl | MK-2206 2HCl 代理商 | 购买 1032350-13-2| 1032350-13-2 供应商 | 订购 1032350-13-2 | 1032350-13-2 价格 | 1032350-13-2 生产商 | 订单 1032350-13-2 | 1032350-13-2 代理商|buy MK-2206 2HCl | MK-2206 2HCl Supplier | purchase MK-2206 2HCl | MK-2206 2HCl cost | MK-2206 2HCl manufacturer | order MK-2206 2HCl | MK-2206 2HCl distributor | buy 1032350-13-2| 1032350-13-2 Supplier | purchase 1032350-13-2 | 1032350-13-2 cost | 1032350-13-2 manufacturer | order 1032350-13-2 | 1032350-13-2 distributor