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MK-2206 2HCl


AKT 抑制剂

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产品目录号: A10003


产品名 目录号 价格 数量
MK-2206 5mg A10003-5
¥ 600.00
MK-2206 10mg A10003-10
¥ 1,000.00
MK-2206 25mg A10003-25
¥ 1,500.00
MK-2206 50mg A10003-50
¥ 2,500.00
MK-2206 2HCl 10mM * 1mL in DMSO A10003-10mM-D
¥ 1,170.00



MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.

MK-2206 2HCl




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MK-2206 2HCl 发表的文献 (10)
  • Nishihama K, .et al. Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus, Metabolism, 2018, May;82:88-99 PMID: 29366755
  • J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
  • Joo Sang Lee, .et al. Harnessing synthetic lethality to predict the response to cancer treatment, Nat Commun, 2018, 9: 2546 PMID: 29959327
  • Wan-Ting Hu, .et al. The O-glycosylating enzyme GALNT2 suppresses the malignancy of gastric adenocarcinoma by reducing EGFR activities, Am J Cancer Res, 2018, 8(9): 1739每1751 PMID: 30323967
  • Angela M. Gocher, .et al. Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells, J Biol Chem, 2017, Aug 25; 292(34): 14188每14204 PMID: 28634229
  • Kusuyama J, .et al. Constitutive activation of p46JNK2 is indispensable for C/EBP汛 induction in the initial stage of adipogenic differentiation, Biochem J, 2017, Oct 5;474(20):3421-3437 PMID: 28887384
  • Pi-Lin Sung, .et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036每4047 PMID: 26716408
  • Mika?l M. Martino, .et al. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration, Nat Commun, 2016, 7: 11051 PMID: 27001940
  • Dominik Schulz, .et al. HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances, Am J Cancer Res, 2016, 6(9): 1963每1975 PMID: 27725902
  • Jewett KA, .et al. The tumor suppressor p53 guides GluA1 homeostasis through Nedd4-2 during chronic elevation of neuronal activity., J Neurochem., 2015, Oct;135(2):226-33 PMID: 26250624

Chemical Information

目录号 A10003
Mechanism of action Inhibitor
分子量 480.4
化学分子式 C25H21N5O.2HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1032350-13-2
Synonyms MK2206
SMILES code C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl
化学名称 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride


MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.
Akt1 (Cell-free assay) Akt2 (Cell-free assay) Akt3 (Cell-free assay)
8 nM12 nM65 nM


Solubility (25°C) * In vitro DMSO 14 mg/mL (29.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 17 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.82 mL 104.08 mL 208.16mL
0.5 mM 4.16 mL 20.82 mL 41.63 mL
1 mM 2.08 mL 10.41 mL 20.82 mL
5 mM 0.42 mL 2.08 mL 4.16 mL

*The above data is based on the productmolecular weight 480.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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