NF-κB

Catalog No.Inhibitor Name NF-κBOther
A12748QNZ (EVP4593)
****
TNF-α
A14142JSH-23
**
A14278SC75741
***
A13698Caffeic Acid Phenethyl Ester
A10077Andrographolide
A15046CID-2858522
***
A16301(+)-DHMEQ
A16302(-)-DHMEQ
A16306Pyrrolidinedithiocarbamate ammonium
A10698Parthenolide
p53,MDM2 ubiquitination,HDAC1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. JSH 23

    Catalog No. A14142
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    NF-κB 抑制剂
    JSH 23是NF-kB的抑制剂,可阻止其转运入细胞核(IC50 = 7.1 uM)。 了解更多
  2. SC75741

    Catalog No. A14278
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    NF-κB 抑制剂
    SC75741是有效的NF-kB抑制剂,EC50为200 nM。 了解更多
  3. CID-2858522

    Catalog No. A15046
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    NF-κB 抑制剂
    CID-2858522选择性抑制由PKC诱导的NF-κB途径 (对于PMA刺激的IL-8产生IC50 <0.1 uM),在PKC下游但在IKKbeta上游起作用,而没有抑制其他NF-κB激活途径。 了解更多
  4. (+)-DHMEQ

    Catalog No. A16301
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    NF-kB 抑制剂
    (+)-DHMEQ是DHMEQ的异构体,(+)-DHMEQ是NF-kB的抑制剂。 了解更多
  5. (-)-DHMEQ

    Catalog No. A16302
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    NF-kB 抑制剂
    (-)-DHMEQ是DHMEQ的eutomer,是一种有效的NF-κB抑制剂,可抑制核因子kB活化,IC50值为20 ug/mL,其活性比(+)-DHMEQ(HY-14645A)强。 了解更多
  6. Pyrrolidinedithiocarbamate ammonium

    Catalog No. A16306
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    NF-kB 抑制剂
    Pyrrolidinedithiocarbamate ammonium是一种选择性的NF-kB抑制剂,可抑制一氧化氮合酶mRNA的翻译以防止诱导。 了解更多
  7. Andrographolide

    Catalog No. A10077
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    Apoptosis Inducer
    Andrographolide是具有抗癌和免疫调节活性的令人感兴趣的药效团,因此具有被开发为癌症治疗剂的潜力。 了解更多
  8. Parthenolide ((-)-Parthenolide)

    Catalog No. A10698
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    Parthenolide ((-)-Parthenolide), Nuclear Factor-κB抑制剂,可特异性地耗尽HDAC1蛋白,而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。 了解更多
  9. QNZ (EVP4593)

    Catalog No. A12748
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    NF-κB 抑制剂
    QNZ抑制转录因子NF-κB的激活,已被用于研究NF-κB信号传导。 了解更多
  10. Caffeic Acid Phenethyl Ester

    Catalog No. A13698
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    NF-κB activation 抑制剂
    Caffeic Acid Phenethyl Ester是一种有效且特异性的NF-κB活化抑制剂。 了解更多
  11. Dehydrocostus Lactone

    Catalog No. A14809
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    Dehydrocostus Lactone通过阻止TNF-α诱导的降解和磷酸化来抑制NFκB的活化。 了解更多
  12. Tomatidine

    Catalog No. A16233
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    ERK/Akt/NF-kB 抑制剂
    Tomatidine抑制ERK,Akt的磷酸化以及NF-kB的核含量。具有抗炎特性。 了解更多
  13. Adjudin

    Catalog No. A16303
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    Adjudin是一种正在开发的潜在的非激素型男性避孕药,它通过阻断睾丸中精子的产生而起作用,但不会影响睾丸激素的产生。 了解更多
  14. CBL-0137

    Catalog No. A16836
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    p53 activator / NF-κB 抑制剂
    CBL0137 (CBL-0137)在基于细胞的p53和NF-kB报告基因检测中分别激活p53和抑制NF-kB,EC50为0.37 uM和0.47 uM。它还抑制组蛋白伴侣FACT(促进染色质转录复合物)。 了解更多
  15. Ac2-26

    Catalog No. A17205
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    NF-κB 抑制剂
    Ac2-26是膜联蛋白A1(AnxA1)的活性N端肽。 了解更多

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