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PF-2341066 (Crizotinib)

促销

ALK/ c-Met 抑制剂

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产品目录号: A10712

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PF-2341066 5mg A10712-5
¥ 300.00
PF-2341066 10mg A10712-10
¥ 500.00
PF-2341066 50mg A10712-50
¥ 1,000.00
PF-2341066 100mg A10712-100
¥ 1,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).

PF-2341066 (Crizotinib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PF-2341066 (Crizotinib) 发表的文献 (4)
  • Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • Saki Omote, .et al. Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1, Sci Rep, 2018, 8: 9237 PMID: 29915248
  • Arakawa H, .et al. Inhibitory Effect of Crizotinib on Creatinine Uptake by Renal Secretory Transporter OCT2, J Pharm Sci, 2017, Sep;106(9):2899-2903 PMID: 28336299

Chemical Information

目录号 A10712
Mechanism of action Inhibitor
分子量 450.3
化学分子式 C21H22Cl2FN5O
Solubility DMSO>23mg/mL Water<1mg/mL Ethanol>8mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 877399-52-5
Synonyms PF02341066
SMILES code C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
化学名称 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

生物活性

Description
PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
Targets
c-Met (A549, MDA-MB-231, GTL-16, HT29, 786-O, Colo-205, A498 cells) ALK (Karpas299 cells)
11 nM24 nM

溶解性

Solubility (25°C) * In vitro DMSO 9 mg/mL (19.98 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC Na 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.21 mL 111.04 mL 222.07mL
0.5 mM 4.44 mL 22.21 mL 44.41 mL
1 mM 2.22 mL 11.1 mL 22.21 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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