PF-2341066 (Crizotinib)

目录号: A10712

ALK/ c-Met inhibitor

PF-2341066 (Crizotinib)

PF-2341066 (Crizotinib) Chemical Structure

CAS NO. 877399-52-5

PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).

库存: 现货

规格 价格 数量
5 mg
¥ 300.00
10 mg
¥ 500.00
50 mg
¥ 1,000.00
100 mg
¥ 1,400.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
Targets
c-Met (A549, MDA-MB-231, GTL-16, HT29, 786-O, Colo-205, A498 cells) ALK (Karpas299 cells)
11 nM24 nM
In vitro (25°C) DMSO 9 mg/mL (19.98 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC Na 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.21 mL 111.04 mL 222.07 mL
0.5 mM 4.44 mL 22.21 mL 44.41 mL
1 mM 2.22 mL 11.1 mL 22.21 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10712
MECHANISM OF ACTION Inhibitor
M. Wt 450.3
Formula C21H22Cl2FN5O
Solubility DMSO>23mg/mL Water<1mg/mL Ethanol>8mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 877399-52-5
Synonyms PF02341066
SMILES C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

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