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(S)-crizotinib

MTH1 (NUDT1) 抑制剂

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产品目录号: A14291

库存状态:中国现货中国现货

产品名 目录号 价格 数量
(S)-crizotinib 10mg A14291-10
¥ 1,500.00
(S)-crizotinib 25mg A14291-25
¥ 3,000.00
(S)-crizotinib 50mg A14291-50
¥ 5,000.00
(S)-crizotinib 10mM * 1mL in DMSO A14291-10mM-D
¥ 1,270.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

(S)-crizotinib

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Chemical Information

目录号 A14291
Mechanism of action Inhibitor
分子量 450.34
化学分子式 C21H22Cl2FN5O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1374356-45-2
Synonyms N/A
SMILES code C[C@@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
化学名称 2-?Pyridinamine, 3-?[(1S)?-?1-?(2,?6-?dichloro-?3-?fluorophenyl)?ethoxy]?-?5-?[1-?(4-?piperidinyl)?-?1H-?pyrazol-?4-?yl]?-

生物活性

Description
(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.
Targets
MTH1 (Cell-free assay)
72 nM

溶解性

Solubility (25°C)* In vitro DMSO 42 mg/mL heating (93.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol 22 mg/mL (48.85 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.21 mL 111.03 mL 222.05mL
0.5 mM 4.44 mL 22.21 mL 44.41 mL
1 mM 2.22 mL 11.1 mL 22.21 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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