(S)-crizotinib

目录号: A14291

MTH1 (NUDT1) inhibitor

(S)-crizotinib

(S)-crizotinib Chemical Structure

CAS NO. 1374356-45-2

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

库存: 现货

规格 价格 数量
10 mg
¥ 1,500.00
25 mg
¥ 3,000.00
50 mg
¥ 5,000.00
10mM * 1mL in DMSO
¥ 1,270.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.
Targets
MTH1 (Cell-free assay)
72 nM
In vitro DMSO 42 mg/mL heating (93.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol 22 mg/mL (48.85 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.21 mL 111.03 mL 222.05 mL
0.5 mM 4.44 mL 22.21 mL 44.41 mL
1 mM 2.22 mL 11.1 mL 22.21 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A14291
MECHANISM OF ACTION Inhibitor
M. Wt 450.34
Formula C21H22Cl2FN5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1374356-45-2
Synonyms N/A
SMILES C[C@@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

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