renin-angiotensin-aldosterone system (RAAS)

Catalog No.Inhibitor Name AT1 receptorAT2 receptorACEReninRAAS
A11123Aliskiren Hemifumarate
***
A10175Candesartan
****
A10351Enalaprilat Dihydrate
***
***
****
A10477Irbesartan
***
A13201PD123319
*
A10710Perindopril Erbumine
***
A10176Candesartan Cilexetil
****
A10778Ramipril
**
A11738Captopril
*
A16420Azilsartan Medoxomil
**
A13747Eprosartan Mesylate
****
A11775Azilsartan
**
A10905Telmisartan
A10123Benazepril HCl
A10350Enalapril Maleate
A11615Olmesartan Medoxomil
A11747Cilazapril Monohydrate
A11876Lisinopril
A11745Moexipril HCl
A11749Temocapril
A11736Quinapril HCl
A14206LCZ696
A11748Fosinopril Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. BIBS39

    Catalog No. A14154
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    angiotensin II receptor 拮抗剂
    BIBS39是一种非肽血管紧张素II(AII)受体拮抗剂,可从其特异性结合位点置换[125I] AII,其AII亚型(AT1)受体和K(i)的K(i)值为29+/-7 nM。)AII亚型2(AT2)受体的480+/-110 nM)值。 了解更多
  2. Azilsartan Medoxomil

    Catalog No. A16420
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    angiotensin II receptor type 1 拮抗剂
    Azilsartan medoxomil是一种口服给药的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。 了解更多
  3. Tasosartan

    Catalog No. A10891
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    Angiotensin II receptor 拮抗剂
    Tasosartan是一种血管紧张素II受体拮抗剂。 了解更多
  4. Telmisartan

    Catalog No. A10905
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    AT1 拮抗剂
    Telmisartan是一种抑制血管紧张素II AT1受体的血管紧张素II受体拮抗剂。 了解更多
  5. Fimasartan

    Catalog No. A17477
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    non-peptide angiotensin II receptor antagonist
    Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. 了解更多
  6. Losartan

    Catalog No. A17510
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    Angiotensin II receptor antagonist
    Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. 了解更多
  7. Azilsartan D5

    Catalog No. A21600
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    angiotensin II type 1 receptor antagonist
    Azilsartan D5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist. 了解更多
  8. Losartan (D4 Carboxylic Acid)

    Catalog No. A21578
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    angiotensin II receptor antagonist
    Losartan D4 Carboxylic Acid is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist. 了解更多
  9. Eprosartan

    Catalog No. A11121
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    AT1 receptor 拮抗剂
    Eprosartan是一种用于治疗高血压的血管紧张素II受体拮抗剂。 了解更多
  10. Sparsentan

    Catalog No. A20879
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    angiotensin II and endothelin A receptor antagonist
    Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively. 了解更多
  11. Azilsartan medoxomil monopotassium

    Catalog No. A20860
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    angiotensin II receptor type 1 antagonist
    Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. 了解更多
  12. Valsartan

    Catalog No. A10962
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    angiotensin II receptor antagonist
    Valsartan (CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure. 了解更多
  13. SL910102

    Catalog No. A13591
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    Angiotensin AT1 receptor antagonist
    SL910102 is a nonpeptide angiotensin AT1 receptor antagonist. 了解更多
  14. EXP-3174

    Catalog No. A15451
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    AT1 receptor 拮抗剂
    EXP-3174是一种有效的选择性非竞争性AT1受体拮抗剂,IC50值为37 nM。 了解更多
  15. Candesartan (Atacand)

    Catalog No. A10175
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    RAAS 拮抗剂
    Candesartan (Atacand)是一种血管紧张素受体阻滞剂(也称为血管紧张素II受体拮抗剂或AIIRA)。 了解更多
  16. Irbesartan (Avapro)

    Catalog No. A10477
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    AT1 拮抗剂
    Irbesartan (Avapro)是一种血管紧张素II受体拮抗剂,IC50为1.3 nM,主要用于治疗高血压。 了解更多
  17. PD 123319 ditrifluoroacetate

    Catalog No. A13201
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    angiotensin AT2 receptor 拮抗剂
    PD 123319 ditrifluoroacetate是一种有效的,选择性的非肽血管紧张素AT2受体拮抗剂。大鼠肾上腺组织和大脑的IC50值分别为34和210 nM。 了解更多

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