DHFR

Catalog No.Inhibitor Name DHFROther
A10707Pemetrexed
****
TS,GARFT
A15207Pemetrexed Disodium Hydrate
****
TS,GARFT
A10021Methotrexate
A11522Pralatrexate

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Methotrexate (Abitrexate)

    Catalog No. A10021
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    DHFR 抑制剂
    Methotrexate (Abitrexate)是一种抑制胸苷酸合成酶和从头嘌呤合成的细胞毒剂。 了解更多
  2. Pemetrexed (Alimta)

    Catalog No. A10707
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    Pemetrexed (Alimta)是一种新型抗叶酸和抗代谢药物,作用于TS,DHFR和GARFT。 了解更多
  3. Aminopterin

    Catalog No. A11787
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    Aminopterin是一种抗肿瘤药。它通过竞争二氢叶酸还原酶的叶酸结合位点而充当酶抑制剂。 了解更多
  4. Pemetrexed disodium

    Catalog No. A12668
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    DHFR 抑制剂
    Pemetrexed disodium是一种具有多个靶标的新型抗叶酸药。作用于TS,DHFR和GARFT,Ki分别为1.3 nM,7.2 nM 和 65 nM。 了解更多
  5. Trimetrexate

    Catalog No. A12796
    Trimetrexate是喹唑啉衍生物。它是二氢叶酸还原酶抑制剂。 了解更多
  6. NSC 131463 (DAMPA)

    Catalog No. A10655
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    DHFR 抑制剂
    NSC 131463 (DAMPA)是有效的二氢叶酸还原酶抑制剂,IC50为1 nM。 了解更多
  7. Pralatrexate

    Catalog No. A11522
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    DHFR 抑制剂
    Pralatrexate是一种抗叶酸剂(叶酸类似物代谢抑制剂),设计用于优先在癌细胞中积累。 了解更多
  8. Pemetrexed disodium hemipenta hydrate

    Catalog No. A15207
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    Pemetrexed disodium hemipenta hydrate是TS,DHFR和GARFT的新型抗叶酸和抗代谢药,Ki分别为1.3 nM,7.2 nM和65 nM。 了解更多
  9. Diaveridine

    Catalog No. A17000
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    DHFR 抑制剂
    Diaveridine(EGIS-5645)是一种二氢叶酸还原酶(DHFR)抑制剂,其野生型DHFR的Ki值为11.5 nM,同时也是一种抗菌剂。 了解更多
  10. WR99210

    Catalog No. A18837
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    DHFR 抑制剂
    WR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of <0.075 nM. WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. 了解更多

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