DHFR
Catalog No. | Inhibitor Name | DHFR | Other |
---|---|---|---|
A10707 | Pemetrexed | **** | TS,GARFT |
A15207 | Pemetrexed Disodium Hydrate | **** | TS,GARFT |
A10021 | Methotrexate | ||
A11522 | Pralatrexate |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Methotrexate (Abitrexate)
Catalog No. A10021 -
Pemetrexed disodium (Alimta)
Catalog No. A10707 Pemetrexed disodium (Alimta)是一种新型抗叶酸和抗代谢药物,作用于TS,DHFR和GARFT。 了解更多 -
Aminopterin
Catalog No. A11787 Aminopterin是一种抗肿瘤药。它通过竞争二氢叶酸还原酶的叶酸结合位点而充当酶抑制剂。 了解更多 -
Pemetrexed
Catalog No. A12668 -
NSC 131463 (DAMPA)
Catalog No. A10655 -
Pralatrexate
Catalog No. A11522 -
Pemetrexed disodium hemipenta hydrate
Catalog No. A15207 Pemetrexed disodium hemipenta hydrate是TS,DHFR和GARFT的新型抗叶酸和抗代谢药,Ki分别为1.3 nM,7.2 nM和65 nM。 了解更多 -
Diaveridine
Catalog No. A17000 DHFR 抑制剂Diaveridine(EGIS-5645)是一种二氢叶酸还原酶(DHFR)抑制剂,其野生型DHFR的Ki值为11.5 nM,同时也是一种抗菌剂。 了解更多