COX

Inhibitory Selectivity

Catalog No.	Inhibitor Name	COX-1	COX-2
A10193	Celecoxib		****
A10461	Ibuprofen	*	*
A10474	Indomethacin	**	*
A11918	Rofecoxib		****
A10304	Diclofenac Sodium	***	***
A11695	Lornoxicam	****	****
A10623	Naproxen Sodium	*	*
A13342	Valdecoxib		****
A11693	Tolfenamic Acid		***
A16399	Amfenac Sodium Monohydrate	**	***
A11694	Nimesulide		*
A12520	Meclofenamate Sodium	****	***
A16428	Carprofen		****
A10636	Nepafenac
A10878	Sulindac
A10565	Meloxicam
A10820	Aspirin
A11906	Phenacetin
A10736	Piroxicam
A10462	Ibuprofen Lysine
A11641	Pranoprofen
A10090	Asaraldehyde
A11692	Acemetacin
A13244	Bromfenac Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Phenacetin

Catalog No. A11906
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Phenacetin是一种非阿片类镇痛药，无抗炎特性。了解更多

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Indomethacin (Indocid, Indocin)

Catalog No. A10474
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COX 抑制剂

Indomethacin (Indocid, Indocin)是一种非选择性COX1和COX2抑制剂，IC50分别为0.1 μg/mL和5 μg/mL。吲哚美辛(吲哚满，吲哚满)是一种非甾体抗炎药，通常用于减轻发热、疼痛、僵硬和肿胀。了解更多

Product Citations (3)

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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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Phenylbutazone (Butazolidin, Butatron)

Catalog No. A10720
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COX 抑制剂

Phenylbutazone (Butazolidin,Butatron)是一种具有研究意义的化合物，它是一种抗炎和抗增殖剂。了解更多

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Piroxicam (Feldene)

Catalog No. A10736
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COX 抑制剂

Piroxicam (Feldene)是前列腺素合成的有效抑制剂，并且是Cox-1和Cox-2抑制剂。了解更多

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Iguratimod (T 614)

Catalog No. A11464
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COX-2 抑制剂

Iguratimod (T 614)是一种抗风湿剂，能够有效地抑制COX-2的活性，IC50值为20 μM (7.7 μg/mL)，而对 COX-1 无作用；Iguratimod同时为巨噬细胞移动抑制因子 (MIF) 抑制剂，IC50值为6.81 μM。了解更多

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Jaceosidin

Catalog No. A12080
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Jaceosidin是一种来源于艾蒿的药理活性黄酮，通过阻断培养的人乳腺上皮细胞中erk-1和-2的磷酸化来抑制佛波酯诱导的cox-2和MMP-9的上调。了解更多

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(S)-(+)-Flurbiprofen

Catalog No. A12434
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COX 抑制剂

(S)-(+)-Flurbiprofen是一种非选择性的Cox-1和Cox-2抑制剂。了解更多

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- Xing Jin, .et al. Enantioselective analysis of ketoprofen in human saliva by liquid chromatography/tandem mass spectrometry with chiral derivatization, Microchemical Journal, 2018, 143: 280-285
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NS-398

Catalog No. A13116
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COX-2 抑制剂?

NS-398是具有镇痛和解热作用的非甾体类抗炎药，可选择性抑制前列腺素G / H合酶2 /环氧合酶2（COX-2）活性，IC50为3.8μM，对COX无影响了解更多

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Bromfenac sodium

Catalog No. A13244
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COX-2 抑制剂

Bromfenac sodium是一种局部选择性环氧合酶(COX)-2抑制剂了解更多

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Acetaminophen

Catalog No. A10030
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COX 抑制剂

Acetaminophen (paracetamol) 是选择性环氧合酶-2 (COX-2) 的抑制剂，IC50 值为 25.8 μM。Acetaminophen 是一种有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。它是广泛使用的解热和止痛药。了解更多

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- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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Naproxen sodium

Catalog No. A10623
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COX 抑制剂

Naproxen sodium是一种非选择性的环氧合酶（COX）抑制剂，具有抗炎，解热和镇痛作用。对秋水仙碱引起的认知障碍和氧化应激具有神经保护作用。了解更多

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FK 3311

Catalog No. A13332
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COX-2 抑制剂

FK3311是一种可渗透细胞且可口服的磺酰苯胺，可作为选择性COX-2抑制剂和NSAID。了解更多

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Valdecoxib

Catalog No. A13342
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COX-2 抑制剂

伐地考昔（Valdecoxib），也称为SC-65872，是一种非甾体类抗炎药（NSAID），用于治疗骨关节炎，类风湿性关节炎以及痛经和月经症状。它是一种选择性的环氧合酶2（COX-2)抑制剂,IC50为5nM。了解更多

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Parecoxib

Catalog No. A13572
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COX-2 抑制剂

Parecoxib是一种有效的选择性COX-2抑制剂。了解更多

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