renin-angiotensin-aldosterone system (RAAS)

Catalog No.Inhibitor Name AT1 receptorAT2 receptorACEReninRAAS
A11123Aliskiren Hemifumarate
***
A10175Candesartan
****
A10351Enalaprilat Dihydrate
***
***
****
A10477Irbesartan
***
A13201PD123319
*
A10710Perindopril Erbumine
***
A10176Candesartan Cilexetil
****
A10778Ramipril
**
A11738Captopril
*
A16420Azilsartan Medoxomil
**
A13747Eprosartan Mesylate
****
A11775Azilsartan
**
A10905Telmisartan
A10123Benazepril HCl
A10350Enalapril Maleate
A11615Olmesartan Medoxomil
A11747Cilazapril Monohydrate
A11876Lisinopril
A11745Moexipril HCl
A11749Temocapril
A11736Quinapril HCl
A14206LCZ696
A11748Fosinopril Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 61个

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  1. BIBS39

    Catalog No. A14154
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    angiotensin II receptor 拮抗剂
    BIBS39是一种非肽血管紧张素II(AII)受体拮抗剂,可从其特异性结合位点置换[125I] AII,其AII亚型(AT1)受体和K(i)的K(i)值为29+/-7 nM。)AII亚型2(AT2)受体的480+/-110 nM)值。 了解更多
  2. Ramipril

    Catalog No. A10778
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    ACE 抑制剂
    Ramipril是一种血管紧张素转化酶(ACE)抑制剂,IC50为5 nM。 了解更多
  3. Azilsartan Medoxomil

    Catalog No. A16420
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    angiotensin II receptor type 1 拮抗剂
    Azilsartan medoxomil是一种口服给药的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。 了解更多
  4. Tasosartan

    Catalog No. A10891
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    Angiotensin II receptor 拮抗剂
    Tasosartan是一种血管紧张素II受体拮抗剂。 了解更多
  5. Eprosartan mesylate

    Catalog No. A13747
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    Eprosartan mesylate是一种竞争性的AT1受体拮抗剂,IC50值为1.4-3.9 nM,消除半衰期为5至7小时。 了解更多
  6. Telmisartan

    Catalog No. A10905
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    AT1 拮抗剂
    Telmisartan是一种抑制血管紧张素II AT1受体的血管紧张素II受体拮抗剂。 了解更多
  7. Fimasartan

    Catalog No. A17477
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    non-peptide angiotensin II receptor antagonist
    Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. 了解更多
  8. Zofenopril calcium

    Catalog No. A12769
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    ACE 抑制剂
    Zofenopril calcium是一种血管紧张素转化酶ACE抑制剂。 了解更多
  9. Imidapril (Tanatril)

    Catalog No. A11867
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    Imidapril (Tanatril)是血管紧张素转化酶(ACE)的抑制剂。 了解更多
  10. Lisinopril (Zestril)

    Catalog No. A11876
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    Lisinopril (Zestril)是血管紧张素转换酶抑制剂,用于治疗高血压,充血性心力衰竭和心脏病发作,还用于预防糖尿病的肾和视网膜并发症。 了解更多
  11. Perindopril Erbumine (Aceon)

    Catalog No. A10710
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    Perindopril Butylamine是一种血管紧张素转化酶(ACE)抑制剂。 了解更多
  12. Losartan

    Catalog No. A17510
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    Angiotensin II receptor antagonist
    Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. 了解更多
  13. H-Val-Pro-Pro-OH

    Catalog No. A18868
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    ACE inhibitor
    H-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM. 了解更多
  14. Zofenopril

    Catalog No. A13615
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    ACE inhibitor
    Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 81 μM. 了解更多
  15. Fosinopril sodium

    Catalog No. A11748
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    ACE 抑制剂
    Fosinopril sodium是一种血管紧张素转换酶(ACE)抑制剂,用于治疗高血压和某些类型的慢性心力衰竭。 了解更多
  16. SL910102

    Catalog No. A13591
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    Angiotensin AT1 receptor antagonist
    SL910102 is a nonpeptide angiotensin AT1 receptor antagonist. 了解更多
  17. AVE 0991

    Catalog No. A20997
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    angiotensin-(1-7) receptor agonist
    AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM. 了解更多
  18. Azilsartan D5

    Catalog No. A21600
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    angiotensin II type 1 receptor antagonist
    Azilsartan D5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist. 了解更多
  19. Losartan (D4 Carboxylic Acid)

    Catalog No. A21578
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    angiotensin II receptor antagonist
    Losartan D4 Carboxylic Acid is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist. 了解更多
  20. CGP-42112

    Catalog No. A21575
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    Angiotensin-II subtype 2 receptor(AT2 R) agonist
    CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist. 了解更多
  21. Eprosartan

    Catalog No. A11121
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    AT1 receptor 拮抗剂
    Eprosartan是一种用于治疗高血压的血管紧张素II受体拮抗剂。 了解更多
  22. Lisinopril

    Catalog No. A21064
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    angiotensin-converting enzyme inhibitor
    Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. 了解更多
  23. Olmesartan (RNH6270, CS-088)

    Catalog No. A10670
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    Olmesartan (RNH6270,CS-088)是一种用于治疗高血压的血管紧张素II受体拮抗剂。 了解更多
  24. Olmesartan medoxomil

    Catalog No. A11615
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    Olmesartan medoxomil是一种用于治疗高血压的血管紧张素II受体拮抗剂。奥美沙坦通过阻断血管紧张素II与血管肌肉AT1受体的结合来发挥作用。通过阻断结合而不是血管紧张素II的合成,奥美沙坦抑制了对肾素分泌的负面调节反馈。 了解更多
  25. Sparsentan

    Catalog No. A20879
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    angiotensin II and endothelin A receptor antagonist
    Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively. 了解更多
  26. Azilsartan medoxomil monopotassium

    Catalog No. A20860
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    angiotensin II receptor type 1 antagonist
    Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. 了解更多
  27. Azilsartan (TAK-536)

    Catalog No. A11775
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    AT1 Receptor Blocker
    Azilsartan (TAK-536)是一种用于治疗高血压的血管紧张素II受体拮抗剂。 了解更多
  28. Imidaprilate

    Catalog No. A20003
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    ACE inhibitor
    Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease. 了解更多
  29. Captopril

    Catalog No. A11738
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    Captopril是一种血管紧张素转换酶(ACE)抑制剂,用于治疗高血压和某些类型的充血性心力衰竭。 了解更多
  30. Moxonidine

    Catalog No. A11317
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    Moxonidine是新一代中枢作用抗高血压药物。是咪唑啉1型受体(I1-R)选择性激动剂,为降压剂。 了解更多
  31. Valsartan

    Catalog No. A10962
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    angiotensin II receptor antagonist
    Valsartan (CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure. 了解更多
  32. MLN-4760

    Catalog No. A16884
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    ACE2 抑制剂
    MLN-4760是血管紧张素转化(ACE2)抑制剂。在huMNC中,MLN-4760-B检测到63%的ACE2,选择性是ACE的28倍。 了解更多
  33. EXP-3174

    Catalog No. A15451
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    AT1 receptor 拮抗剂
    EXP-3174是一种有效的选择性非竞争性AT1受体拮抗剂,IC50值为37 nM。 了解更多
  34. Spinorphin

    Catalog No. A15314
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    Enkephalin-degrading and ACE 抑制剂
    Spinorphin是一种内源性因子,对脑啡肽降解酶具有抑制作用。 了解更多
  35. VTP-27999 2,2,2-trifluoroacetate

    Catalog No. A15281
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    Renin 抑制剂
    VTP-27999 2,2,2-trifluoroacetate是一种烷基胺肾素抑制剂。VTP-27999可用于高血压和末梢器官疾病。 了解更多
  36. Angiotensin 1/2 + A (2 - 8)

    Catalog No. A14888
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    Angiotensin 1/2 + A (2 - 8)有效的内源性血管收缩肽;血管紧张素(Ang)的衍生物II。 了解更多
  37. Angiotensin 1/2 (1-6)

    Catalog No. A14887
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    Angiotensin 1/2 (1-6)是一种包含氨基酸1-6的肽,是从血管紧张素I/II肽转化而来的。 了解更多
  38. Aliskiren hemifumarate

    Catalog No. A11123
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    renin 抑制剂
    Aliskiren hemifumarate是阿利吉仑的半富马酸盐形式,是批准用于治疗原发性高血压的直接肾素抑制剂,IC50为1.5 nM。 了解更多
  39. Candesartan (Atacand)

    Catalog No. A10175
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    RAAS 拮抗剂
    Candesartan (Atacand)是一种血管紧张素受体阻滞剂(也称为血管紧张素II受体拮抗剂或AIIRA)。 了解更多
  40. Benazepril HCl

    Catalog No. A10123
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    RAAS 抑制剂
    Benazepril hydrochloride是一种非肽血管紧张素转化酶(ACE)抑制剂。降低自发性高血压大鼠的血压和心肌肥大。 了解更多
  41. Clinofibrate

    Catalog No. A11184
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    HMG-CoA Reductase 抑制剂
    Clinofibrate是一种脂质清除剂,似乎可以改变脂质代谢,减少类固醇诱导的骨细胞内脂质堆积。它还可以有效降低血浆纤维蛋白原水平。抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)(羟甲基戊二酰辅酶A还原酶),IC50为0.47 mM。 了解更多
  42. Rosuvastatin

    Catalog No. A11122
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    HMG-CoA reductase 抑制剂
    Rosuvastatin是用于治疗高胆固醇和相关疾病的抑制剂。 了解更多
  43. Irbesartan (Avapro)

    Catalog No. A10477
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    AT1 拮抗剂
    Irbesartan (Avapro)是一种血管紧张素II受体拮抗剂,IC50为1.3 nM,主要用于治疗高血压。 了解更多
  44. Aliskiren (CGP 60536)

    Catalog No. A11616
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    Renin 抑制剂
    Aliskiren (CGP 60536)是一种合成非肽肾素抑制剂。 了解更多
  45. Candesartan cilexetil (Atacand)

    Catalog No. A10176
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    Candesartan Cilexetil一种特异性的,非肽类血管生成素II受体(ATR)拮抗剂,也是Candesartan的前体药物,是ATR拮抗剂 了解更多
  46. Quinapril hydrochloride

    Catalog No. A11736
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    Quinapril hydrochloride是一种催化血管紧张素II从其前体血管紧张素I形成的酶。 了解更多
  47. Moexipril hydrochloride

    Catalog No. A11745
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    Moexipril hydrochloride是一种有效的口服活性非巯基血管紧张素转换酶抑制剂(ACE),可作用于高血压和充血性心力衰竭。 了解更多
  48. Cilazapril monohydrate

    Catalog No. A11747
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    ACE 抑制剂
    Cilazapril monohydrate是哒嗪血管紧张素转换酶抑制剂(ACE抑制剂),用于治疗高血压和充血性心力衰竭。 了解更多
  49. Temocapril

    Catalog No. A11749
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    ACE 抑制剂
    Temocapril是一种ACE抑制剂。 了解更多
  50. Enalapril maleate

    Catalog No. A10350
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    ACE 抑制剂
    Enalapril maleate是一种血管紧张素转换酶(ACE)抑制剂,用于治疗高血压和某些类型的慢性心力衰竭。 了解更多

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