Serine Protease

Catalog No.Inhibitor Name Serine ProteaseOther
A14263Aprotinin
***
Thrombin,Trypsin,kallikrein
A12779Alvelestat (AZD9668)
****
A10617Nafamostat Mesylate
A11901PMSF
cysteine protease
A14145Leupeptin Hemisulfate
Cysteine protease
A14270AEBSF HCl

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

19 个项目

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  1. Upamostat

    Catalog No. A21035
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    serine protease inhibitor
    Upamostat is a serine protease inhibitor. Upamostat is the orally available prodrug of the WX-UK1, which is a urokinase plasminogen activator (uPA) inhibitor. 了解更多
  2. Nafamostat

    Catalog No. A20827
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    serine protease inhibitor
    Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. 了解更多
  3. Nafamostat hydrochloride

    Catalog No. A20828
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    serine protease inhibitor
    Nafamostat hydrochloride is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. 了解更多
  4. SPHINX31

    Catalog No. A18640
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    Serine/arginin kinase 1 inhibitor
    SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM). 了解更多
  5. AA26-9

    Catalog No. A17158
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    serine hydrolase inhibitor
    AA26-9是一种有效的广谱丝氨酸水解酶抑制剂。 了解更多
  6. Fumonisin B1

    Catalog No. A15379
    serine/threonine phosphatase 抑制剂
    Fumonisin B1是由镰孢镰刀菌(Fusarium moniliforme)产生的真菌代谢产物,已显示可抑制蛋白质丝氨酸/苏氨酸磷酸酶(PP1,PP2A,PP2B,PP2C和PP5/T/K/H),并且对PP5最有效。 了解更多
  7. Sivelestat sodium hydrate (ONO-5046 sodium hydrate)

    Catalog No. A16137
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    Neutrophil elastase 抑制剂
    Sivelestat sodium hydrate (ONO-5046 sodium hydrate)是人嗜中性粒细胞弹性蛋白酶的竞争性抑制剂,还抑制从兔,大鼠,仓鼠和小鼠获得的白细胞弹性蛋白酶。 了解更多
  8. PMSF

    Catalog No. A11901
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    Serine/cysteine protease 抑制剂
    PMSF是不可逆的丝氨酸/半胱氨酸蛋白酶抑制剂。 了解更多
  9. SSR 69071

    Catalog No. A15315
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    HLE 抑制剂
    SSR 69071是中性粒细胞弹性蛋白酶(人白细胞弹性蛋白酶,HLE)的高亲和力强抑制剂(IC50 = 3.9 nM)。 了解更多
  10. AAF-CMK

    Catalog No. A13605
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    Serine protease 抑制剂
    AAF-CMK是一种丝氨酸蛋白酶抑制剂,它不可逆地抑制TPPII(三肽基肽酶II),TPPII是一种巨大的蛋白酶,可以替代某些蛋白酶体功能,并且可逆地抑制Cln2(TPPI)。 了解更多
  11. Sivelestat

    Catalog No. A14184
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    Neutrophil elastase 抑制剂
    Sivelestat是一种可渗透细胞的磺酰苯胺化合物,可作为中性粒细胞弹性蛋白酶的强效,底物竞争性和高度特异性抑制剂(大鼠,兔,仓鼠,人类和小鼠白细胞弹性蛋白酶的IC50 = 19-49 nM)。 了解更多
  12. Aprotinin

    Catalog No. A14263
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    serine protease 抑制剂
    Aprotinin是一种小蛋白丝氨酸蛋白酶抑制剂,用于减少围手术期失血和输血。 了解更多
  13. AEBSF HCl

    Catalog No. A14270
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    serine protease 抑制剂
    AEBSF HCl是一种广谱的不可逆丝氨酸蛋白酶抑制剂。 了解更多
  14. Leupeptin hemisulfate

    Catalog No. A14145
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    Cysteine Protease 抑制剂
    Leupeptin hemisulfate是胰蛋白酶样和半胱氨酸蛋白酶如钙蛋白酶的可逆抑制剂。 了解更多
  15. Alvelestat

    Catalog No. A12779
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    neutrophil elastase 抑制剂
    Avelestat,也称为AZD9668,是可口服的,高度选择性neutrophil elastase (NE)抑制剂,IC50和Ki分别为12 nM和9.4 nM,其选择性超过其他丝氨酸蛋白酶至少600倍。 了解更多
  16. Sivelestat sodium salt

    Catalog No. A14073
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    Neutrophil elastase 抑制剂
    Sivelestat sodium salt是一种选择性白细胞弹性蛋白酶抑制剂(IC50 = 44 nM),在一系列其他蛋白酶中均无活性。它在体外抑制NF-κB活化和LTB4诱导的中性粒细胞转运。 了解更多
  17. BCX 1470 methanesulfonate

    Catalog No. A11325
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    Serine protease 抑制剂
    BCX 1470 methanesulfonate是丝氨酸蛋白酶抑制剂。BCX 1470在体外阻断补体酶CLs和因子D的酯酶和溶血活性。 了解更多
  18. BCX 1470

    Catalog No. A11331
    Serine protease 抑制剂
    BCX 1470是丝氨酸蛋白酶抑制剂。bcx 1470在体外阻断补体酶cls和因子d的酯酶和溶血活性。 了解更多
  19. Nafamostat mesylate

    Catalog No. A10617
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    serine protease 抑制剂
    Nafamostat mesylate是一种抗凝剂。广谱丝氨酸蛋白酶抑制剂。在哮喘小鼠模型中减少嗜酸性粒细胞浸润,肥大细胞活化和气道反应性。 了解更多

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