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ferroptosis 抑制剂
Ferrostatin-1（Fer-1）是一种强效且选择性的铁死亡抑制剂，其EC50为60 nM。- Cheng Chen, .et al. , Neurochem Res, 2025, Mar 18;50(2):122 PMID: 40100474
- Yin-Yin Wang, .et al. , Bioorg Chem, 2025, May:158:108342 PMID: 40058224
- Filiz Bakar-Ates, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2024, Oct 11 PMID: 39392483
- Rushikesh Deshpande, .et al. , Int J Mol Sci, 2024, Jan 18;25(2):1157 PMID: 38256231
- Huan Yang, .et al. , Theriogenology, 2024, Feb:215:281-289 PMID: 38103405
- Filiz Bakar-Ates, .et al. , Toxicol In Vitro, 2024, Feb:94:105732 PMID: 37956772
- Binjie Yan, .et al. , Cell Death Discov, 2023, 9: 456 PMID: 38097554
- Panpan Tai, .et al. , J Transl Med, 2023, Nov 17;21(1):823 PMID: 37978379
- Chengzhu Song, .et al. , Food Funct, 2023, Jan 23;14(2):1087-1098 PMID: 36594456
- Erva Ozkan, .et al. , Life Sci, 2023, Jan 1;312:121222 PMID: 36442526
- Xueyan Zhang, .et al. , DNA Cell Biol, 2022, Aug;41(8):705-715 PMID: 35687364
- A Xavier, .et al. , Cell Rep, 2020, May 19;31(7):107667 PMID: 32433976
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15-LO 抑制剂
PD146176 (NSC168807) 是一种 15-脂氧合酶（15-LO）抑制剂，能够抑制兔网织红细胞的 15-LO，其抑制常数 Ki 为 197 nM。PD146176 (NSC168807) 在减少动脉粥样硬化方面具有显著效果。 -
VDAC 抑制剂
Erastin 是一种细胞渗透性的哌嗪基喹唑啉酮化合物，对带有 H-Ras 突变的细胞表现出 癌基因选择性致死性。- Mao Yang, .et al. , Biochem Biophys Res Commun, 2025, Sep 5:784:152599 PMID: 40972362
- Xuejie Huan, .et al. , Neurosci Bull, 2024, Dec 12 PMID: 39666195
- Filiz Bakar-Ates, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2024, Oct 11 PMID: 39392483
- Filiz Bakar-Ates, .et al. , Toxicol In Vitro, 2024, Feb:94:105732 PMID: 37956772
- Sureya Nijiati, .et al. , Mol Pharm, 2023, Oct 2;20(10):5185-5194 PMID: 37711135
- Erva Ozkan, .et al. , Life Sci, 2023, Jan 1;312:121222 PMID: 36442526
- Yuki Shibata, .et al. , Biochem Biophys Rep, 2021, Feb 24;26 PMID: 33681481
- Shibata Y, .et al. , PLoS One, 2019, Dec 4;14(12):e0225931 PMID: 31800616
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Ferroptosis 抑制剂
RSL3 是一种以 VDAC-独立方式激活 铁死亡 的化合物，对携带致癌 RAS 的肿瘤细胞表现出选择性。- Cheng Chen, .et al. , Neurochem Res, 2025, Mar 18;50(2):122 PMID: 40100474
- Xiaona Cao, .et al. , J Nanobiotechnology, 2025, Feb 24;23(1):136 PMID: 39994619
- Naoya Yamada, .et al. , Nat Commun, 2024, 15:2195
- Ning Li, .et al. , J Ovarian Res, 2024, Feb 23;17(1):49 PMID: 38396022
- Yuki Kojima, .et al. , Journal of Gastroenterology, 2023, Nov 10
- Qingyu Zhang, .et al. , Cell Death Discov, 2023, Mar 8;9(1):83 PMID: 36882396
- Sampilvanjil A, .et al. , Am J Physiol Heart Circ Physiol, 2020, Mar 1;318(3):H508-H518 PMID: 31975626
- Fujiki K, .et al. , Cell Death Differ, 2019, Feb 25 PMID: 30804470
- Samantha W. Alvarez, .et al. , Nature, 2017, Nov 30; 551(7682): 639-643 PMID: 29168506
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GPX4 抑制剂
ML-210，硝基异噁唑系列中最有效的化合物，是通过与硒代半胱氨酸残基结合，选择性共价抑制谷胱甘肽过氧化物酶4（GPX4）的抑制剂。- Ning Li, .et al. , J Ovarian Res, 2024, Feb 23;17(1):49 PMID: 38396022
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g-glutamylcysteine synthetase 抑制剂
L-丁硫氨酸-(S,R)-亚砜亚胺是一种细胞渗透性强、作用迅速且不可逆的抑制剂，它能有效抑制γ-谷氨酰半胱氨酸合成酶，并耗尽细胞内的谷胱甘肽水平。
