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Cytoskeleton /
Integrin

Integrin

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Cyclo(RGDyK)

Catalog No. A21819
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αVβ3 integrin inhibitor

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM. 了解更多

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Carotegrast

Catalog No. A21997
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α4 integrin receptor inhibitor

Carotegrast is an orally available α4 integrin receptor inhibitor with anti-inflammatories activities. 了解更多

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ATN-161 trifluoroacetate salt

Catalog No. A21412
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integrin α5β1 antagonist

ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model. 了解更多

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ATN-161

Catalog No. A21307
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integrin α5β1 antagonist

ATN-161 is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model. 了解更多

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MK-0429

Catalog No. A21173
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αvβ3 integrin antagonist

MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM. 了解更多

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Integrin Antagonists 27

Catalog No. A20895
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integrin αvβ3 antagonist

Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent. 了解更多

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GLPG0187

Catalog No. A13423
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Integrin receptor antagonist

GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM. 了解更多

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R-BC154

Catalog No. A17184
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α4β1/α9β1 抑制剂

R-BC154是高亲和力的荧光α4β1/α9 9β1抑制剂。了解更多

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Obtustatin

Catalog No. A17185
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α1β1 抑制剂

Obtustatin是高度有效的整联蛋白α1β1抑制剂（α1β1与IV型胶原的结合的IC 50 = 0.8 nM）。与α2β1，βIIbβ3，αvβ3，α4β1，β5β6，α9β1和α4β7相比，α1β1具有选择性。在鸡绒膜尿囊炎模型中抑制FGF2刺激的血管生成。在Lewis肺癌的协同小鼠模型中显示抗肿瘤功效；阻止人黑素瘤在裸鼠中的生长。了解更多

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TCS2314

Catalog No. A17193
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Integrin 抑制剂

TCS2314是整联蛋白极晚期抗原4（VLA-4，α4β1）拮抗剂，IC50值为4.4 nM。了解更多

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BTT-3033

Catalog No. A17200
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α2β1 integrin 抑制剂

BTT-3033是α2β1整联蛋白抑制剂。了解更多

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BOP sodium salt

Catalog No. A17201
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α9β1/α4β1 integrin 抑制剂

BOP sodium salt是新型的双重alpha9beta1/alpha4beta1整联蛋白抑制剂。了解更多

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BIO-1211

Catalog No. A17210
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Integrin alpha4beta1 抑制剂

BIO-1211是整联蛋白alpha4beta1抑制剂。了解更多

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- 最新产品
TR-14035

Catalog No. A17118
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Integrin 拮抗剂

TR-14035是α4β7和α4β1整联蛋白的双重拮抗剂。了解更多

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A-205804

Catalog No. A13047
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Integrin 抑制剂

A-205804是E-选择素和ICAM-1的有效和选择性抑制剂，IC50值分别为20 nM和25 nM。了解更多

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CWHM12

Catalog No. A15967
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αV integrins 抑制剂

CWHM 12可以抑制所有5个alpha V整联蛋白。CWHM12不仅以与遗传删除方法相同的方式预防纤维化，还可以防止肝和肺中现有纤维化的进展，并逆转了由纤维化对这些器官造成的某些损害。了解更多

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Cyclo (RGDyK) trifluoroacetate

Catalog No. A15918
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Integrin 抑制剂

Cyclo (RGDyK) trifluoroacetate是一种有效的选择性αVbeta3整联蛋白抑制剂，IC50为20 nM。了解更多

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E7820

Catalog No. A15456
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lpha-2-integrin 抑制剂

E7820是一种小分子芳香族磺酰胺衍生物，具有潜在的抗血管生成和抗肿瘤活性。E7820通过抑制整合素α2（一种在内皮细胞上表达的细胞粘附分子）来抑制血管生成。了解更多

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RGD (Arg-Gly-Asp) Peptides

Catalog No. A15538
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Inhibits integrin binding to RGD motifs

RGD (Arg-Gly-Asp) Peptides是一种细胞粘附基序，可以模拟细胞粘附蛋白并与整联蛋白结合。了解更多

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Cyclo (-RGDfK)

Catalog No. A14923
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αvβ3 integrin 抑制剂

Cyclo (-RGDfK)是一种有效的、选择性的整合素抑制剂。了解更多

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- Julian Tu, .et al. A Stable Precursor for Bioorthogonally Removable 3-Isocyanopropyloxycarbonyl (ICPrc) Protecting Groups, Synlett, 2020, 31, A-F
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Leukadherin 1

Catalog No. A13968
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Integrin 激动剂

Leukadherin 1是CD11b/CD18的变构激活剂。增加CD11b/CD18依赖性细胞对血纤蛋白原的粘附（EC50 = 4μM）。了解更多

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Pyrintegrin

Catalog No. A12876
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pyintegrin是一种细胞可渗透的小分子，可将人类胚胎干细胞（hESC）的存活率提高30倍以上。了解更多

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Firategrast (SB 683699)

Catalog No. A12787
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α4β1/α4β7 integrin 拮抗剂

Firategrast (SB 683699)是一种口服可生物利用的alpha4 beta1/alpha4 beta7整联蛋白拮抗剂，旨在减少淋巴细胞向中枢神经系统（CNS）的运输。了解更多

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- Higuchi S, .et al. Inhibition of the integrin signal constitutes a mouse iPS cell niche, Dev Growth Differ, 2016, Sep;58(7):586-99 PMID: 27633818
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Cilengitide trifluoroacetate

Catalog No. A12371
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Integrin 抑制剂

Cilengitide trifluoroacetate是一种具有潜在抗肿瘤活性的环状精氨酸-甘氨酸-天冬氨酸肽。西仑吉肽结合并抑制α(v)β(3)和α(v)β(5)整联蛋白的活性，从而抑制内皮细胞-细胞相互作用、内皮细胞-基质相互作用和血管生成。了解更多

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- Yi Han Tan, .et al. Complement-activated vitronectin enhances the invasion of nonphagocytic cells by bacterial pathogens Burkholderia and Klebsiella, Cell Microbiol, 2017, Aug;19(8) PMID: 28186697
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Cilengitide

Catalog No. A12372
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Integrin 抑制剂

Cilengitide是一种具有潜在抗肿瘤活性的环状精氨酸-甘氨酸-天冬氨酸肽。西仑吉肽结合并抑制α(v)β(3)和α(v)β(5)整联蛋白的活性，从而抑制内皮细胞-细胞相互作用、内皮细胞-基质相互作用和血管生成。了解更多

Product Citations (6)

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- Marion Bouvet, .et al. Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells, Sci Rep, 2020, 10: 11404 PMID: 32647159
- Rosalie Richards, .et al. 4D imaging and analysis of multicellular tumour spheroid cell migration and invasion, bioRxiv, 2018, 15 Oct 2018
- Hiroki Kanazawa, .et al. Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts, PLoS One, 2017, 12(2): e0173051 PMID: 28235037
- Yasuda J, .et al. T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway, Naunyn Schmiedebergs Arch Pharmacol, 2017, Nov;390(11):1135-1144 PMID: 28785775
- Yasuda J, .et al. T3 peptide, an active fragment of tumstatin, inhibits H2O2-induced apoptosis in H9c2 cardiomyoblasts, Eur J Pharmacol, 2017, Jul 15;807:64-70 PMID: 28457922
- Hsian-Yu Wang, .et al. Non-small-cell lung cancer cells combat epidermal growth factor receptor tyrosine kinase inhibition through immediate adhesion-related responses, Onco Targets Ther, 2016, 9: 2961-2973 PMID: 27284246
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Zaurategrast (CDP323)

Catalog No. A11614
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VCAM-1 拮抗剂

Zaurategrast (CDP323)是与α4-整合素结合的血管细胞粘附分子1的小分子前药拮抗剂。了解更多

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- Mustafa Ahmadzai, .et al. Integrins are Mechanosensors That Modulate Human Eosinophil Activation, Front Immunol, 2015, 6: 525 PMID: 26539194

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