PERK

Catalog No.Inhibitor Name PERKOther
A12792GSK2606414
****
EIF2AK1 (HRI),EIF2AK2 (PKR)
A13577GSK2656157
***
A13816ISRIB (trans-isomer)
**
A12676Salubrinal

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Salubrinal

    Catalog No. A12676
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    eIF2α dephosphorylation 抑制剂
    Salubrinal是细胞磷酸酶复合物的可渗透细胞的选择性抑制剂,可将真核翻译起始因子2亚基α(eIF2α)磷酸化。保护细胞免受内质网应激诱导的细胞凋亡(EC50?15 μM)。 了解更多
  2. GSK2606414

    Catalog No. A12792
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    PERK 抑制剂
    GSK2606414是口服有效的选择性PERK抑制剂,IC50为0.4 nM。 了解更多
  3. GSK2656157

    Catalog No. A13577
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    PERK 抑制剂
    GSK2656157是PERK酶活性的ATP竞争性抑制剂,IC50为0.9 nmol/L。 对于PER(K)IC50值> 100 nmol/L,对300种激酶组合具有高度选择性。 了解更多
  4. ISRIB (trans-isomer)

    Catalog No. A13816
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    PERK 抑制剂
    ISRIB (trans-isomer)是一种有效的选择性小分子PERK信号抑制剂(IC50?5 nM),可以有效逆转eIF2α磷酸化的作用。 了解更多
  5. ISRIB

    Catalog No. A14302
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    PERK 抑制剂
    ISRIB是一种有效的选择性PERK抑制剂,IC50为5 nM。 了解更多
  6. Azoramide

    Catalog No. A16075
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    UPR modulator
    Azoramide是具有抗糖尿病活性的未折叠蛋白应答的小分子调节剂。 了解更多
  7. CCT020312

    Catalog No. A19137
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    EIF2AK3/PERK activator
    CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells. 了解更多

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