Tie-2

Catalog No.Inhibitor Name Tie-2Other
A10996Cabozantinib
***
VEGFR2/KDR,c-Met,Kit
A10587MGCD-265
****
Met,RON,VEGFR2
A10932Tie2 kinase inhibitor
**
A13456AMG-Tie2-1
****
A10895Pexmetinib (ARRY-614)
p38 MAPK
A14387Altiratinib (DCC2701)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. XL184 free base (Cabozantinib)

    Catalog No. A10996
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    VEGFR 抑制剂
    XL184 free base (Cabozantinib)是设计用来抑制多种受体酪氨酸激酶(特别是MET和VEGFR2)的小分子。 了解更多
  2. CE-245677

    Catalog No. A19377
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    Tie2 and TrkA/B inhibitor
    CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. 了解更多
  3. MGCD-265 (Glesatinib)

    Catalog No. A10587
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    c-Met 抑制剂
    MGCD-265 (Glesatinib)是一种多靶酪氨酸激酶抑制剂,可与多种RTK(包括c-Met受体(HGFR)结合并抑制其磷酸化。Tek/Tie-2受体;VEGFR类型1、2和3;和MST1R。 了解更多
  4. Tie2 kinase inhibitor

    Catalog No. A10932
    Tie2 kinase inhibitor
    Tie2 kinase inhibitor是一种有效的选择性Tie2抑制剂,IC50为0.25μM。 了解更多
  5. AMG-Tie2-1

    Catalog No. A13456
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    Tie-2 抑制剂
    AMG-Tie2-1是Tie-2的高效非选择性抑制剂(IC50 <1 nM)。 了解更多
  6. Altiratinib (DCC2701)

    Catalog No. A14387
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    c-Met/VEGFR 抑制剂
    Altiratinib (DCC2701)是一种新型的c-MET/TIE-2/VEGFR抑制剂;与体外HGF拮抗剂相比,可有效降低体内的肿瘤负荷并阻断c-MET pTyr(1349)介导的信号传导,细胞生长和迁移。 了解更多
  7. Pexmetinib (ARRY-614)

    Catalog No. A10895
    p38 MAPK 抑制剂
    Pexmetinib (ARRY-614)是通过双重抑制p38促分裂原活化蛋白激酶(MAPK)和Tie2/Tek受体酪氨酸激酶,其在HEK-293细胞中的IC50分别为4 nM/18 nM。Pexmetinib是一种有效的细胞因子合成抑制剂。 了解更多

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