TNF-α

Catalog No.Inhibitor Name TNF-αOther
A10743Pomalidomide
***
A11973Necrostatin-1
*
A12748QNZ
****
NF-κB
A10924Thalidomide
A10522Lenalidomide (CC-5013)
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Lenalidomide (CC-5013)

    Catalog No. A10522
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    Ubiquitin ligase inducer
    Lenalidomide (CC-5013)是Thalidomide的衍生物。在体外,Lenalidomide具有三种主要活性:直接抗肿瘤作用、抑制肿瘤细胞的微环境支持和免疫调节作用。它通过抑制骨髓基质细胞支持、抗血管生成和抗破骨细胞生成作用以及免疫调节活性直接和间接诱导肿瘤细胞凋亡。 了解更多
  2. QNZ (EVP4593)

    Catalog No. A12748
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    NF-κB 抑制剂
    QNZ抑制转录因子NF-κB的激活,已被用于研究NF-κB信号传导。 了解更多
  3. Pomalidomide (CC-4047)

    Catalog No. A10743
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    TNF-alpha 抑制剂
    Pomalidomide (CC-4047)是沙利度胺的衍生物,在PBMCs中IC50为13 nM,并起免疫调节剂的作用。 了解更多
  4. Necrostatin-1

    Catalog No. A11973
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    RIPK1 抑制剂
    Necrostatin-1是一种与ATP竞争的,与受体相互作用的蛋白激酶1(RIPK1)的变构抑制剂(EC50 = 182 nM)。 了解更多
  5. GW 4869

    Catalog No. A11974
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    N-SMase 抑制剂
    W4869是N-SMase(中性鞘磷脂酶)的细胞渗透性选择性抑制剂。 了解更多
  6. Necrostatin 2

    Catalog No. A15183
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    Necroptosis 抑制剂
    Necrostatin 2 是一种有效的坏死性抑制剂,EC50为50 nM。 了解更多
  7. Necrostatin 2 racemate

    Catalog No. A15327
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    Necroptosis 抑制剂
    Necrostatin 2 racemate是一种有效的坏死性抑制剂,EC50为50 nM。 了解更多
  8. Necrostatin 2 S enantiomer

    Catalog No. A15328
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    Necroptosis 抑制剂
    Necrostatin 2 S enantiomer是一种有效的坏死性抑制剂,EC50为50 nM。 了解更多
  9. Thalidomide

    Catalog No. A10924
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    E3 ubiquitin ligase 抑制剂
    Thalidomide可以在体内直接抑制bFGF或VEGF诱导的血管生成。 了解更多
  10. C 87

    Catalog No. A12313
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    TNFα inhibitor
    C87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM. 了解更多

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