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Sirtuins



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Catalog No. Product Name Application Product Information
A10862 SALE

SRT1720 HCl

SIRT1 Activator
SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.
A15902 SALE

SirReal2

Selective SIRT2 抑制剂
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
A15247

SRT 1720

SIRT1 Activator
SRT 1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 uM??SIRT3: EC1.5 > 300 uM).
A14370

AK-1

SIRT2 抑制剂
AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3.
A14225 SALE

AGK2

SIRT2 抑制剂
AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM.
A14188

SRT2104 (GSK2245840)

SIRT1 activator
SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
A12527

Inauhzin

SIRT1 抑制剂
Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.
A12904

AK-7

SIRT2 抑制剂
AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).
A10377 SALE

EX 527 (Selisistat)

SIRT1 抑制剂
EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.
A12226 SALE

Sirtinol

sirtuin 抑制剂
Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.
A10388 SALE

Fisetin (Fustel)

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Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation.

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