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Sirtuins

Catalog No.	Product Name	Application	Product Information
A10862 SALE	SRT1720 HCl	SIRT1 Activator	SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1. Product Citations (6) Jie Ren,et al. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice, Sleep Breath, 2018, Nov 8 30411173 Rowlands BD,et al. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation, J Neurochem, 2017, Mar;140(6):903-918 27925207 Adam Khader,et al. SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis, J Surg Res, 2017, Nov;219:288-295 29078895 Adam Khader,et al. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy, Crit Care Med, 2016, Aug; 44(8): e651-e663 26963320 Benjamin D. Rowlands,et al. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism., J Neurosci Res., 2015, Jul;93(7):1147-56 25677687 Khader A,et al. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion., Transplantation, 2014, 98(2):148-56 24918615
A15902 SALE	SirReal2	Selective SIRT2 抑制剂	SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. Product Citations (1) Yang Li,et al. SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism, Neoplasia, 2018, Jul; 20(7): 745-756 29925042
A15247	SRT 1720	SIRT1 Activator	SRT 1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 uM??SIRT3: EC1.5 > 300 uM). Product Citations (5) A Khader ,etc. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion. Transplantation, 2014, 98(2), 148-156. BD Rowlands ,etc. SIRT1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism while SRT1720 increases oxidative metabolism. , 2015, 93:1147-1156. BD Rowlands ,etc. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism. Journal of neuroscience research, 2015, 93(7), 1147-1156. A Khader ,etc. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy. Critical care medicine, 2016, 44(8), e651-e663. BD Rowlands ,etc. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation. Journal of Neurochemistry, 2016, 140(6):903-918. .
A14370	AK-1	SIRT2 抑制剂	AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3.
A14225 SALE	AGK2	SIRT2 抑制剂	AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM.
A14188	SRT2104 (GSK2245840)	SIRT1 activator	SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
A12527	Inauhzin	SIRT1 抑制剂	Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.
A12904	AK-7	SIRT2 抑制剂	AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).
A10377 SALE	EX 527 (Selisistat)	SIRT1 抑制剂	EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay. Product Citations (2) Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48 Yoshikawa A, .et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice, J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847
A12226 SALE	Sirtinol	sirtuin 抑制剂	Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.
A10388 SALE	Fisetin (Fustel)	-	Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation. Product Citations (3) Jeng LB,et al. Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo, J Cell Physiol, 2018, Sep;233(9):7134-7142 29574877 Kuan-Ho Lin,et al. Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats, Journal of Functional Foods, 2018, 52: 212-218 Bih-Cheng Chen,et al. Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats, Phytomedicine, 2019, Apr; 57:1-8