HMG-CoA Reductase
Catalog No. | Inhibitor Name | HMG-CoA Reductase |
---|---|---|
A10810 | Rosuvastatin Calcium | ** |
A11877 | Lovastatin | *** |
A11912 | Pravastatin sodium | ** |
A11184 | Clinofibrate | * |
A11800 | Atorvastatin Calcium | |
A13709 | Mevastatin |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Clinofibrate
Catalog No. A11184 HMG-CoA Reductase 抑制剂Clinofibrate是一种脂质清除剂,似乎可以改变脂质代谢,减少类固醇诱导的骨细胞内脂质堆积。它还可以有效降低血浆纤维蛋白原水平。抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)(羟甲基戊二酰辅酶A还原酶),IC50为0.47 mM。 了解更多 -
Rosuvastatin
Catalog No. A11122 -
2-Hydroxy atorvastatin calcium salt
Catalog No. A18971 HMG-CoA reductase inhibitor2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. 了解更多 -
Simvastatin
Catalog No. A10845 HMG-CoA reductase inhibitorSimvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. 了解更多 -
Fluvastatin sodium
Catalog No. A10403 HMG-CoA reductase inhibitorFluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. 了解更多 -
Fluvastatin
Catalog No. A21232 HMG-CoA reductase inhibitorFluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. 了解更多 -
Rosuvastatin calcium (Crestor)
Catalog No. A10810 HMG-CoA reductase 抑制剂Rosuvastatin calcium (Crestor)是他汀类药物中的一员,用于治疗高胆固醇及相关疾病,并预防心血管疾病。罗苏伐他汀是一种竞争性HMG-CoA reductase抑制剂,无细胞试验中IC50为11 nM。 了解更多 -
Pravastatin sodium
Catalog No. A11912 HMG-CoA reductase 抑制剂Pravastatin sodium是3-羟基-3-甲基辅酶A(HMG-CoA)还原酶的水溶性竞争性抑制剂。有效阻断体内胆固醇合成(Ki?1 nM)并显示出心脏保护特性。 了解更多 -
Atorvastatin calcium
Catalog No. A11800 HMG-CoA reductase 抑制剂Atorvastatin calcium (Lipitor)是HMG-CoA还原酶的抑制剂,可用作降低胆固醇的药物,可阻止胆固醇的产生。 了解更多 -
Pitavastatin calcium (Livalo)
Catalog No. A10737 HMG-CoA reductase 抑制剂Pitavastatin calcium (Livalo)是HMGCR(HMG-CoA还原酶)酶的竞争性抑制剂,可降低LDL胆固醇的合成。 了解更多 -
Lovastatin (Mevacor)
Catalog No. A11877 HMG-CoA reductase 抑制剂Lovastatin (Mevacor)是HMG-CoA还原酶的抑制剂,IC50为3.4 nM,用于降低胆固醇。 了解更多 -
Swertiamarin
Catalog No. A12128 -
Mevastatin
Catalog No. A13709 -
Atorvastatin
Catalog No. A13743 HMG-CoA reductase 抑制剂Atorvastatin是一种HMG-CoA还原酶抑制剂(IC50 = 154 nM),可有效治疗高胆固醇血症和某些血脂异常。 了解更多 -
Pitavastatin Lactone
Catalog No. A13896