Autophagy

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  1. Lys01 trihydrochloride

    Catalog No. A21702
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    lysosomal autophagy inhibitor
    Lys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. 了解更多
  2. Aumitin

    Catalog No. A18838
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    Autophagy inhibitor
    Aumitin is an autophagy inhibitor, targeting mitochondrial complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively. 了解更多
  3. EACC

    Catalog No. A19062
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    Autophagy inhibitor
    EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. 了解更多
  4. IITZ-01

    Catalog No. A20192
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    Lysosomotropic autophagy inhibitor
    IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. 了解更多
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    Autophinib

    Catalog No. A17241
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    Autophagy inhibitor
    Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34. 了解更多
  5. ROC-325

    Catalog No. A17031
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    Autophagy 抑制剂
    ROC-325是自噬抑制剂。与现有的自噬抑制剂羟氯喹(HCQ)相比,ROC-325在具有不同遗传背景的12种不同癌细胞系中表现出优异的体外抗癌作用。 了解更多
  6. Monensin sodium

    Catalog No. A10603
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    ionophore
    Monensin sodium是一种离子载体,是自噬在牲畜饲料中的抑制剂。它抑制自噬,干扰自噬体和溶酶体的融合。 了解更多
  7. PIK-III

    Catalog No. A15868
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    Autophagy 抑制剂
    PIK-III是βVPS34酶活性的选择性抑制剂。 了解更多
  8. 3-Methyladenine

    Catalog No. A11151
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    Autophagy/PI3K 抑制剂
    3-Methyladenine是III类磷脂酰肌醇3-激酶(PI 3-激酶)的抑制剂。 了解更多
  9. Lys05

    Catalog No. A16358
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    Autophagy 抑制剂
    Lys05是有效的溶酶体自噬抑制剂。Lys05是一种先前未描述的二聚氯喹,与HCQ相比,它更有效地积聚在溶酶体中并阻止自噬。 了解更多
  10. MRT68921

    Catalog No. A15880
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    Autophagy ULK1/2 抑制剂
    MRT68921是一种有效的双重自噬激酶ULK1/2抑制剂,IC50分别为2.9 nM和1.1 nM。 了解更多
  11. SBI-0206965

    Catalog No. A15795
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    ULK1 抑制剂
    SBI-0206965是一种有效的,选择性的且细胞可渗透的自噬激酶ULK1抑制剂,对于ULK1激酶活性,IC50为108 nM;对于高度相关的激酶ULK2,IC50为711 nM。 了解更多
  12. Spautin-1

    Catalog No. A12942
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    Autophagy 抑制剂
    Spautin-1是一种新型的自噬抑制剂,IM抑制K562细胞的生长,IC50为1.03μM。相反,与Spautin-1共同处理可增加IM诱导的细胞活力抑制,IC50为0.45μM。 了解更多

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