c-Ret

Catalog No.Inhibitor Name c-RETOther
A10250Regorafenib
****
Raf-1,VEGFR2,Kit
A10715Danusertib
**
Aurora A,Abl,TrkA
A11180TG101209
***
JAK2,FLT3,JAK3
A13832RPI-1
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Regorafenib (BAY 73-4506)

    Catalog No. A10250
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    VEGFR 抑制剂
    Regorafenib (BAY 73-4506)是一种多激酶抑制剂,IC50为17、40和69 nM c-KIT,VEGFR2,B-Raf。Regorafenib(BAY 73-4506)是一种针对肿瘤及其脉管系统的口服生物利用型多激酶抑制剂。 了解更多
  2. Danusertib (PHA-739358)

    Catalog No. A10715
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    Aurora 抑制剂
    Danusertib (PHA-739358)是Aurora A/B/C的Aurora激酶抑制剂,在无细胞分析中的IC50为13 nM/79nM/61 nM,对Abl,TrkA,c-RET和FGFR1以及更低的浓度具有中等效力 对Lck,VEGFR2/3,c-Kit,CDK2等有效。 了解更多
  3. TG101209

    Catalog No. A11180
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    JAK2 抑制剂
    TG101209是一种新型的JAK2抑制剂,无细胞试验中IC50为6 nM,对Flt3和RET作用效果稍弱,IC50分别为25 nM和17 nM,作用于JAK2比作用于JAK3选择性高30倍左右,对JAK2V617F和MPLW515L/K突变型敏感。在多发性骨髓瘤中具有显着的体外活性,并且对CD45+骨髓瘤细胞显示出优先的细胞毒性。 了解更多
  4. RPI-1

    Catalog No. A13832
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    Ret kinase 抑制剂
    RPI-1是一种竞争性强效ATP依赖性Ret激酶抑制剂。 了解更多
  5. Regorafenib monohydrate

    Catalog No. A15218
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    Tyrosine kinase 抑制剂
    Regorafenib monohydrate是VEGFR1/VEGFR2/VEGFR3/PDGFRβ/Kit/RET和Raf-1的多靶点抑制剂,IC50分别为13 nM/4.2 nM/46 nM/22 nM/7 nM/1.5 nM和2.5 nM。 了解更多
  6. RET-IN-1

    Catalog No. A19015
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    RET inhibitor
    RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively . 了解更多
  7. Regorafenib Hydrochloride

    Catalog No. A11546
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    VEGFR1/2/3/PDGFRβ/Kit/RET/Raf-1 inhibitor
    Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. 了解更多
  8. cis-Pralsetinib

    Catalog No. A21586
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    RET inhibitor
    cis-Pralsetinib (cis-BLU-667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50s ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types. 了解更多
  9. BBT594

    Catalog No. A21039
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    RET inhibitor
    BBT594 is a potent receptor tyrosine kinase RET inhibitor, used for cancer treatment. 了解更多

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