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￥ 0.00 DNA-PK
| Catalog No. | Inhibitor Name | DNA-PK | Other |
|---|---|---|---|
| A10726 | PI-103 | ** | p110α,p110δ,p110β |
| A11098 | NU7441 | *** | mTOR,PI3K |
| A10729 | PIK-75 | **** | p110α,p110γ,p110δ |
| A12752 | NU7026 | * | PI3K |
| A11207 | PP121 | ** | PDGFR,Hck,VEGFR |
| A13224 | KU-0060648 | *** | PI3Kδ,PI3Kβ,PI3Kα |
| A11778 | Compound 401 | * | mTOR,PI3K |
| A13328 | ETP-46464 | *** | ATM, ATR, PI3Kα, mTOR |
| A15779 | CC-115 | *** | mTOR |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
14 个项目
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NU-7441 (KU-57788)
Catalog No. A11098 DNA-PK 抑制剂NU-7441 (KU-57788)是一种有效的选择性DNA依赖性蛋白激酶（DNA-PK）抑制剂。对于DNA-PK，mTOR，PI 3-K，ATM和ATR，IC50值分别为14、1700、5000，> 100000和> 100000 nM。 了解更多 -
PIK-75 hydrochloride
Catalog No. A10729 PI3K 抑制剂PIK-75是一种p110α抑制剂，IC50值为5.8nM。在p110γ和p110β的效果较差，IC50值为0.076 ?M和1.3 ?M。 了解更多 -
Compound 401
Catalog No. A11778 DNA-PK 抑制剂Compound 401是一种细胞可渗透的嘧啶-异喹啉酮化合物，可作为有效的，可逆的和ATP竞争的DNA-PK抑制剂（IC50 = 280 nM），选择性是mTOR（IC50 = 5.3μM）的19倍。 了解更多 -
KU 0060648
Catalog No. A13224 DNA-PK 抑制剂KU0060648是一种有效且选择性的DNA依赖性蛋白激酶（DNA-PK）抑制剂（IC50 = 8.6 nM）；对DNA-PK的选择性是其他PIKK的20-1000倍，并且有60种激酶。KU-0060648可提高HDR效率并衰减NHEJ频率。 了解更多 -
CC-115
Catalog No. A15779 -
NU6027
Catalog No. A14136 -
Nedisertib
Catalog No. A17055 DNA-PK 抑制剂Nedisertib (M-3814,MSC2490484A)是一种可口服的DNA依赖性蛋白激酶（DNA-PK）抑制剂，具有潜在的抗肿瘤和化学/放射增敏活性。 了解更多 -
(Rac)-Nedisertib
Catalog No. A21383 DNA-PK inhibitor(Rac)-Nedisertib ((Rac)-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM. 了解更多
14 个项目
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