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HCV Protease

Inhibitory Selectivity
Catalog No.Inhibitor Name HCV Protease
A10159Daclatasvir (BMS-790052)
****
A10902Telaprevir (VX-950)
**
A10980Lomibuvir (VX-222, VCH-222)
*
A10284Danoprevir (ITMN-191)
***
A13155Ledipasvir (GS5885)
A11294Anguizole
**
A11295Asunaprevir (BMS-650032)
****
A11332Boceprevir (SCH-503034)
***
A11343Ciluprevir (BILN 2061)
***
A11580Simeprevir
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A14106

Faldaprevir

HCV Protease 抑制剂
Faldaprevir is a hepatitis C virus protease inhibitor.
A11600

Vaniprevir

HCV NS3/4A protease 抑制剂
Vaniprevir is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.
A11580

Simeprevir

HCV NS3/4A protease 抑制剂
Simeprevir is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).
A11510

Nesbuvir

HCV 抑制剂
HCV-796 is a selectively inhibitor of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
A15479

VCH-759

HCV Polymerase 抑制剂
VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC50 values versus genotype 1a/1b replicons.
A15224

RO-9187

HCV replication 抑制剂
RO-9187 is a potent inhibitor of HCV virus replication in the replicon system (IC(50) = 171 +/- 12 nM; CC(50) >1 mM).
A15168

MK-5172 sodium salt

HCV 抑制剂
MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development.
A15167

MK-5172 potassium salt

HCV 抑制剂
MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development.
A15166

MK-5172 hydrate

HCV 抑制剂
MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development.
A14046

GS-9451

HCV NS3/4A protease 抑制剂
GS-9451, a novel hepatitis C virus (HCV) nonstructural 3/4a (NS3/4a) protease inhibitor, is highly active in patients infected with HCV genotype 1 (GT 1).
A13965

MK 8742 (elbasvir)

HCV NS5A 抑制剂
MK 8742, also known as Elbasvir, is a HCV NS5A inhibitor, which is an all-oral, interferon-free regimen for the treatment of HCV infection.
A12374

VCH-916

HCV NS5B polymerase 抑制剂
VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
A13105

Setrobuvir (ANA-598)

HCV Polymerase 抑制剂
Setrobuvir (ANA-598) is a direct-acting antiviral or DAA, is a non-nucleoside inhibitor of the HCV RNA polymerase
A13118

Celgosivir

alpha-glucosidase I 抑制剂
Celgosivir is an alpha-glucosidase I inhibitor for the potential treatment of HCV infection.
A13155 SALE

Ledipasvir (GS 5885)

NS5A 抑制剂
Ledipasvir is an inhibitor of the hepatitis C virus HCV NS5A protein
A11529 SALE

PSI-7977

HCV Nucleotide 抑制剂
PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).
A11530 SALE

PSI-6206

HCV RNA polymerase 抑制剂
PSI-6206 is the deaminated derivative of PSI-6130, which is a potent inhibitor of hepatitis C virus (HCV) replication in the subgenomic HCV reolicon system.
A13787

MK-5172

HCV NS3/4a 抑制剂
MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
A13526

GS-9256

HCV NS3 抑制剂
GS-9451 is a potent macrocyclic HCV NS3 PI that achieved a median maximal change in HCV RNA of 3.6 log10 IU/mL (range, -4.7 log10 to -3.1 log10 IU/mL) following 3-day monotherapy in treatment-nave patients with HCV genotype 1 infection during phase I.
A13414

BI207127 (Deleobuvir)

HCV NS5B polymerase 抑制剂
BI 207127 was a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C
A11583

Tegobuvir (GS-9190)

NS5B polymerase 抑制剂
Tegobuvir (GS-9190 is a non-nucleoside NS5B polymerase inhibitor.
A11519 SALE

PSI-6130

HCV Nucleoside 抑制剂
PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor.
A11343 SALE

Ciluprevir (BILN 2061)

HCV NS3 protease 抑制剂
Ciluprevir is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease.
A10159 SALE

BMS-790052 (Daclatasvir)

HCV NS5A 抑制剂
BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.
A10284 SALE

Danoprevir (RG7227)

HCV NS3/4A protease 抑制剂
Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.
A10980

VX-222

HCV Protease 抑制剂
VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
A10902 SALE

Telaprevir (VX-950)

HCV NS3-4A protease 抑制剂
Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease.
A11294

Anguizole

HCV replication 抑制剂
Anguizole is a small molecule inhibits HCV replication and alters NS4B's subcellular distribution.
A11295 SALE

Asunaprevir (BMS-650032)

NS3 protease 抑制剂
Asunaprevir is an inhibitor of the viral enzyme serine protease NS3.
A11332 SALE

Boceprevir (SCH-503034)

HCV Protease 抑制剂
Boceprevir is a protease inhibitor used as a treatment for hepatitis C genotype 1.
A11335

Balapiravir (R1626)

Polymerase 抑制剂
Balapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479).
A11336

BMS-790052 2HCl

NS5A 抑制剂
BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.
A11506

Narlaprevir

NS3 protease 抑制剂
Narlaprevir is a potent, selective, orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM)

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