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Protein Kinase C (PKC)
Catalog No. | Inhibitor Name | PKC | PKCα | PKCβ | PKCγ | PKCδ | PKCε | PKCζ | PKCη | PKCθ | PKCμ | Other |
---|---|---|---|---|---|---|---|---|---|---|---|---|
A10356 | Enzastaurin | ** | *** | * | * | |||||||
A11554 | Sotrastaurin | **** | **** | **** | **** | **** | **** | |||||
A10864 | Staurosporine | **** | **** | ** | * | * | **** | c-Fgr,phosphorylase kinase,S6 kinase | ||||
A13790 | Go 6983 | *** | *** | *** | *** | ** | * | |||||
A13197 | Bisindolylmaleimide I | ** | *** | ** | PDGFR | |||||||
A13514 | Ro 31-8220 Mesylate | **** | *** | ** | ** | |||||||
A12650 | Midostaurin | ** | ** | ** | * | * | * | * | PPK,KDR,c-Syk | |||
A12419 | Go6976 | *** | **** | *** | FLT3,JAK2 | |||||||
A10766 | Quercetin | Sirtuin,Src,PI3Kγ | ||||||||||
A10616 | Myricitrin | |||||||||||
A10196 | Chelerythrine chloride | * | ||||||||||
A10261 | Bryostatin 1 | *** | ||||||||||
A10286 | Daphnetin | * | EGFR, PKA | |||||||||
A12399 | Ruboxistaurin (LY333531) | * | **** | * | * | ** | ||||||
A14871 | PKC (19-36) | * |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
Catalog No. | Product Name | Application | Product Information |
---|---|---|---|
A12650 |
PKC 412 (Midostaurin) |
PKC 抑制剂 |
PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.
|
A16213 |
NSC305787 |
PKC 抑制剂 |
NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 uM, 9.4 uM, 55 uM for PKC phosphorylation of recombinant ezrin, of moesin, and of radixin.
|
A16212 |
PKC-IN-1 |
PKC 抑制剂 |
PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1.
|
A13043 |
(-)-Indolactam V |
PKC activator |
(-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm.
|
A14871 |
PKC (19-36) |
PKC 抑制剂 |
PKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM).
|
A14616 |
12-O-tetradecanoyl phorbol-13-acetate |
PKC activator |
12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations.
|
A13514 SALE |
Ro 31-8220 |
PKC 抑制剂 |
Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.
|
A13790 |
GO6983 |
PKC 抑制剂 |
GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
|
A13094 |
alpha-Amyloid Precursor Protein Modulator |
- |
|
A13197 SALE |
GF 109203X |
PKC 抑制剂 |
GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
|
A12014 SALE |
Verbascoside |
PKC 抑制剂 |
Potentially causes increased protein expression levels of PARP-1 and p53. Inhibitor of Protein Kinase C and shown to be effective against colitis.
|
A14307 |
NH125 |
eEF-2 抑制剂 |
NH125 is a selective eEF-2 kinase inhibitor.
|
A14336 SALE |
Valrubicin |
- |
Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin.
|
A13679 |
Prostratin |
PKC activator |
Prostratin is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans.
|
A14882 |
[Ser25] Protein Kinase C (19-31) |
- |
Protein Kinase C (19-31), this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity.
|
A15557 SALE |
TAS 301 |
PKC 抑制剂 |
TAS 301 is an inhibitor of smooth muscle cell migration and proliferation.
|
A12399 |
Ruboxistaurin (LY333531) |
PKC 抑制剂 |
Ruboxistaurin (LY333531) is a potent, selective inhibitor of Protein Kinase C isozymes, PKC β I(IC50=4.7 nM) and PKC β II (IC50=5.9 nM).
|
A12419 |
Go 6976 |
PKC 抑制剂 |
Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.
|
A10356 SALE |
LY317615 (Enzastaurin) |
PKC?? 抑制剂 |
LY317615 (Enzastaurin) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC50= ~6 nM).
|
A10286 SALE |
Daphnetin |
EGFR, PKA,PKC 抑制剂 |
Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.
|
A10766 SALE |
Quercetin (Sophoretin) |
MAO-B 抑制剂 |
Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C.
|
A10196 SALE |
Chelerythrine Chloride |
PKC 抑制剂 |
Chelerythrine affects translocation of PKC from cytosol to plasma membrane. Shown to prevent neurite growth. Induces apoptosis in a concentration- and schedule-dependent manner. |
A10616 |
Myricitrin (Myricitrine) |
- |
Myricitrin is the 3-O-rhamnoside of myricetin. Myricitrin is used by several beetle species in their communication system.
|
A10261 |
Bryostatin 1 |
PKC 抑制剂 |
Bryostatin 1 is a macrolactone isolated from the marine bryozoan, Bugula neritina, that modulates protein kinase C (PKC) activity. Bryostain 1 induces an initial rapid activation and autophosphorylation of PKC that results in the translocation of the PKC enzyme to the membrane.
|
A11554 SALE |
Sotrastaurin (AEB071) |
PKC 抑制剂 |
Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
|
A10864 SALE |
Staurosporine |
PKC 抑制剂 |
Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.
|
A12963 |
Ingenol Mebutate (PEP005) |
- |
Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.
|