Protein Kinase C (PKC)

Inhibitory Selectivity

Catalog No.	Inhibitor Name	PKC	PKCα	PKCβ	PKCγ	PKCδ	PKCε	PKCζ	PKCη	PKCθ	PKCμ	Other
A10356	Enzastaurin		**	***	*		*
A11554	Sotrastaurin		****	****		****	****		****	****
A10864	Staurosporine		****		****	**	*	*	****			c-Fgr,phosphorylase kinase,S6 kinase
A13790	Go 6983		***	***	***	***		**			*
A13197	Bisindolylmaleimide I		**	***	**							PDGFR
A13514	Ro 31-8220 Mesylate		****	***	**		**
A12650	Midostaurin		**	**	**	*	*	*	*			PPK,KDR,c-Syk
A12419	Go6976	***	****	***								FLT3,JAK2
A10766	Quercetin											Sirtuin,Src,PI3Kγ
A10616	Myricitrin
A10196	Chelerythrine chloride	*
A10261	Bryostatin 1	***
A10286	Daphnetin	*										EGFR, PKA
A12399	Ruboxistaurin (LY333531)		*	****	*	*			**
A14871	PKC (19-36)	*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No.	Product Name	Application	Product Information
A16213	NSC305787	PKC 抑制剂	NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 uM, 9.4 uM, 55 uM for PKC phosphorylation of recombinant ezrin, of moesin, and of radixin.
A13790	GO6983	PKC 抑制剂	GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
A12650	PKC 412 (Midostaurin)	PKC 抑制剂	PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.
A13514 SALE	Ro 31-8220	PKC 抑制剂	Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%. Product Citations (1) Dao-Lai Zhang,et al. Gq activity- and 汕-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 29393851
A14616	12-O-tetradecanoyl phorbol-13-acetate	PKC activator	12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. Product Citations (1) 孙哲 ,etc. 右美托咪定对痛觉过敏大鼠脊髓 PKCγ, CaMKⅡα 及 pCaMKⅡα 表达的影响. 天津医药, 2016, 44(6), 700-703.
A14871	PKC (19-36)	PKC 抑制剂	PKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM).
A13043	(-)-Indolactam V	PKC activator	(-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm.
A16212	PKC-IN-1	PKC 抑制剂	PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1.
A14882	[Ser25] Protein Kinase C (19-31)	-	Protein Kinase C (19-31), this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity.
A15557 SALE	TAS 301	PKC 抑制剂	TAS 301 is an inhibitor of smooth muscle cell migration and proliferation.
A12963	Ingenol Mebutate (PEP005)	-	Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.
A13679	Prostratin	PKC activator	Prostratin is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans.
A14336 SALE	Valrubicin	-	Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin.
A14307	NH125	eEF-2 抑制剂	NH125 is a selective eEF-2 kinase inhibitor.
A12014 SALE	Verbascoside	PKC 抑制剂	Potentially causes increased protein expression levels of PARP-1 and p53. Inhibitor of Protein Kinase C and shown to be effective against colitis. Product Citations (1) SA Shah ,etc. Anti-blepharitis compositions and their use. , 2016, Patent US9439917.
A10286 SALE	Daphnetin	EGFR, PKA,PKC 抑制剂	Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.
A10766 SALE	Quercetin (Sophoretin)	MAO-B 抑制剂	Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C.
A10196 SALE	Chelerythrine Chloride	PKC 抑制剂	Chelerythrine affects translocation of PKC from cytosol to plasma membrane. Shown to prevent neurite growth. Induces apoptosis in a concentration- and schedule-dependent manner.
A10616	Myricitrin (Myricitrine)	-	Myricitrin is the 3-O-rhamnoside of myricetin. Myricitrin is used by several beetle species in their communication system.
A10261	Bryostatin 1	PKC 抑制剂	Bryostatin 1 is a macrolactone isolated from the marine bryozoan, Bugula neritina, that modulates protein kinase C (PKC) activity. Bryostain 1 induces an initial rapid activation and autophosphorylation of PKC that results in the translocation of the PKC enzyme to the membrane.
A11554 SALE	Sotrastaurin (AEB071)	PKC 抑制剂	Sotrastaurin is a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis.
A10864 SALE	Staurosporine	PKC 抑制剂	Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase. Product Citations (2) Jacobs CL,et al. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins, Nat Methods, 2018, Jul;15(7):523-526 29967496 Birte Plitzko,et al. The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells, J Biol Chem, 2017, Dec 22; 292(51): 21102-21116 29074620
A12419	Go 6976	PKC 抑制剂	Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.
A12399	Ruboxistaurin (LY333531)	PKC 抑制剂	Ruboxistaurin (LY333531) is a potent, selective inhibitor of Protein Kinase C isozymes, PKC β I(IC50=4.7 nM) and PKC β II (IC50=5.9 nM).
A13094	alpha-Amyloid Precursor Protein Modulator	-
A13197 SALE	GF 109203X	PKC 抑制剂	GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
A10356 SALE	LY317615 (Enzastaurin)	PKC?? 抑制剂	LY317615 (Enzastaurin) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC50= ~6 nM).

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Protein Kinase C (PKC)

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Protein Kinase C (PKC)

A16213

A13790

A12650

A13514 SALE

A14616

A14871

A13043

A16212

A14882

A15557 SALE

A12963

A13679

A14336 SALE

A14307

A12014 SALE

A10286 SALE

A10766 SALE

A10196 SALE

A10616

A10261

A11554 SALE

A10864 SALE

A12419

A12399

A13094

A13197 SALE

A10356 SALE