Cell Metabolism

产品 1 到 50 共 66个

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  1. GW0742

    Catalog No. A14958
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    PPAR 激动剂
    GW0742是PPARδ的选择性激动剂,EC50值为1.1 nM。 了解更多
  2. GW1929

    Catalog No. A15099
    PPAR 激动剂
    GW1929是一种合成的过氧化物酶体增殖物激活受体-γ(PPARγ)激动剂,对人和人的IC50为6.2 nM和13 nM。 了解更多
  3. Balaglitazone

    Catalog No. A15013
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    PPAR-γ partial 激动剂
    Balaglitazone是PPAR-γ(γ)的新型局部激动剂。 了解更多
  4. BMS-687453

    Catalog No. A15836
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    PPAR 激动剂
    BMS-687453是一种有效的选择性过氧化物酶体增殖物激活受体(PPAR)α激动剂,对人PPARα的EC(50)为10 nM,在PPAR-GAL4反式激活试验中,选择性是对人PPARgamma的410倍。 了解更多
  5. Aleglitazar

    Catalog No. A12492
    PPAR-α/γ 激动剂
    Aleglitazar是一种新型的双重PPAR-α/γ激动剂,IC50为2.8 nM/4.6 nM。 了解更多
  6. Elafibranor

    Catalog No. A15454
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    PPAR 激动剂
    Elafibranor是过氧化物酶体增殖物激活的受体-α和-δ的激动剂,可诱导非酒精性脂肪性肝炎消退,而不会使纤维化恶化。 了解更多
  7. CDDO-Im

    Catalog No. A16308
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    PPARγ 激动剂
    CDDO-Im是一种新型的合成三萜,在体外和体内均比其母体化合物CDDO更有效。PPARγ激动剂。 了解更多
  8. 5-Aminosalicylic Acid

    Catalog No. A10570
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    PPARγ agonist
    5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 了解更多
  9. Pioglitazone hydrochloride

    Catalog No. A16670
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    PPARγ agonist
    Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. 了解更多
  10. Fonadelpar

    Catalog No. A20848
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    PPARδ agonist
    Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy. 了解更多
  11. Tesaglitazar

    Catalog No. A20891
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    PPAR alpha/gamma agonist
    Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively. 了解更多
  12. Arhalofenate

    Catalog No. A21135
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    PPARγ agonist
    Arhalofenate (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes. 了解更多
  13. Indeglitazar

    Catalog No. A21148
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    PPAR agonist
    Indeglitazar is an orally available peroxisome proliferator-activated receptor (PPAR) pan-agonist for all three PPAR subtypes alpha (α), delta (δ) and gamma (γ). 了解更多
  14. Inolitazone

    Catalog No. A21180
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    PPARγ agonist
    Inolitazone a novel high-affinity PPARγ agonist that is dependent upon PPARγ for its biological activity with IC50 of 0.8 nM for growth inhibition. 了解更多
  15. Rosiglitazone maleate

    Catalog No. A10809
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    PPAR 激动剂
    Rosiglitazone maleate是一种噻唑烷二酮类抗高血糖药,是PPARγ的高亲和、选择性的激动剂。 了解更多
  16. Pioglitazone (Actos)

    Catalog No. A11680
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    PPARγ 激动剂
    Pioglitazone (Actos)是选择性刺激核受体过氧化物酶体增殖物激活的受体γ(PPAR-γ),并在较小程度上刺激PPAR-α。 了解更多
  17. Rosiglitazone (BRL-49653)

    Catalog No. A10807
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    PPAR 激动剂
    Rosiglitazone (BRL-49653)是有效的降糖药,也是有效的噻唑烷二酮类胰岛素增敏剂,在大鼠,3T3-L1和人体脂肪细胞中IC50分别为12,4和9 nM。Rosiglitazone是PPAR-gamma的配体,对PPAR-alpha没有结合力。 了解更多
  18. Troglitazone

    Catalog No. A11981
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    PPARγ 激动剂
    Troglitazone是一种选择性PPARγ受体激动剂(鼠和人PPARγ受体的EC50值分别为780和555 nM)。 了解更多
  19. GW 7647

    Catalog No. A11982
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    PPARα 激动剂
    GW 7647是一种有效且高度选择性的PPARα激动剂(人PPARα,PPARγ和PPARδ受体的EC50值分别为6、1100和6200 nM)。 了解更多
  20. L-165,041

    Catalog No. A11983
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    PPARδ 激动剂
    L-165,041是有效的PPARδ激动剂(Ki = 6 nM);与其他亚型相比,对小鼠和人类PPARδ受体的选择性显示> 100倍。 了解更多
  21. pirinixic acid (WY 14643)

    Catalog No. A12360
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    PPARα 激动剂
    pirinixic acid (WY 14643)是一种高效pparα激动剂。 了解更多
  22. GW 501516

    Catalog No. A11437
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    PPARδ receptor 激动剂
    GW501516是一种合成pparδ特异性激动剂,对pparδ (ki=1.1 nm)显示出高亲和力,其选择性超过pparα和pparγ的1000倍。 了解更多
  23. Inolitazone dihydrochloride

    Catalog No. A15129
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    PPARγ 激动剂
    Inolitazone dihydrochloride是一种新型的高亲和力PPARγ激动剂,可激活PPARγ,其EC50约为罗格列酮的EC50,对RIE细胞无影响。 了解更多
  24. Bezafibrate

    Catalog No. A16307
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    PPAR 激动剂
    Bezafibrate是首个经过临床测试的双重和泛PPAR共同激动剂。 了解更多
  25. Clofibric Acid

    Catalog No. A16463
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    PPARα 激动剂
    Clofibric Acid是PPARα激动剂和降血脂药。 了解更多
  26. Etofylline

    Catalog No. A17491
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    PPAR agonist
    Etofylline, also known as BRN-0251760, is a peroxisome proliferator-activated receptor (PPAR) agonist used to treat respiratory and cardiovascular disorders. Etofylline is often used as a bronchodilator. 了解更多
  27. BR102375

    Catalog No. A18849
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    PPAR γ agonist
    BR102375 is a non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) full agonist for the treatment of type 2 diabetes, reveals EC50 value of 0.28?μM and Amax ratio?of 98%. 了解更多
  28. VCE-004.8

    Catalog No. A18549
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    PPARγ and CB2 receptor dual agonist
    VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity. 了解更多
  29. LJ570

    Catalog No. A20081
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    PPARα/PPARγ dual agonist
    LJ570 is a PPARα/PPARγ dual agonist with EC50s of 1.05 and 0.12 μM, respectively. 了解更多
  30. Leriglitazone

    Catalog No. A18636
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    PPAR gamma agonist
    Leriglitazone is a peroxisome proliferator activated receptor (PPAR) gamma agonist. 了解更多
  31. Chiglitazar

    Catalog No. A12701
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    PPARα/γ dual agonist
    Chiglitazar is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively. 了解更多
  32. LXR-623

    Catalog No. A21366
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    LXRα and full LXRβ agonist
    LXR-623 is a brain-penetrant partial LXRα and full LXRβ agonist, with IC50s of 24 nM and 179 nM, respectively. 了解更多
  33. RGX-104 free Acid

    Catalog No. A21513
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    LXR agonist
    RGX-104 free Acid is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. 了解更多
  34. AZ876

    Catalog No. A21026
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    LXR agonist
    AZ876 is a novel high-affinity LXR agonist. 了解更多
  35. GW3965 HCl

    Catalog No. A11204
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    LXR-like receptors 激动剂
    GW3965 HCl是一种选择性的口服活性肝X受体(LXR)完全激动剂。 了解更多
  36. T0901317

    Catalog No. A12652
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    LXR/FXR 激动剂
    T0901317是有效的,高亲和力的肝X受体(LXR)激动剂(EC50~50 nM,LXR-β和LXR-β的Kd值分别为7和22 nM)。 了解更多
  37. GW3965

    Catalog No. A15100
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  38. Sobetirome

    Catalog No. A15241
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    TRβ 激动剂
    Sobetirome是一种甲状腺激素受体β(TRβ)特异性激动剂,Sobetirome设计用于选择性结合TRβ-1,EC50为0.16 μM。 了解更多
  39. SR9243

    Catalog No. A15535
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    LXR 激动剂
    SR9243是有效的选择性LXR反向激动剂。SR9243通过抑制脂质产生和Warburg效应杀死癌细胞。它在多种类型的癌症中诱导细胞死亡,并且不会引起副作用,而这些副作用已使先前针对这些过程的尝试脱轨。 了解更多
  40. SR9238

    Catalog No. A15763
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    LXR Inverse 激动剂
    SR9238是有效的选择性LXR反向激动剂(LXRβ和LXRα的IC50值分别为43和214 nM)。 了解更多
  41. Cilofexor

    Catalog No. A13143
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    FXR agonist
    Cilofexor (GS-9674) is a farnesoid X receptor (FXR) agonist. 了解更多
  42. Nidufexor

    Catalog No. A12625
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    FXR agonist
    Nidufexor is a farnesoid X receptor (FXR) agonist. 了解更多
  43. INT-767

    Catalog No. A21494
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    dual FXR/TGR5 agonist
    INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. 了解更多
  44. Fexaramine

    Catalog No. A21771
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    FXR agonist
    Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. 了解更多
  45. GW4064

    Catalog No. A11141
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    FXR 激动剂
    GW4064是选择性的非甾体类法尼醇X受体(FXR)激动剂(EC50 = 15 nM)。 了解更多
  46. WAY-362450

    Catalog No. A11186
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    FXR 激动剂
    WAY-362450是一种高效,选择性和口服可生物利用的法呢类X受体(FXR)激动剂(EC50:4 nM,eff = 149%)。 了解更多
  47. Lithocholic acid

    Catalog No. A12547
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    FXR 激动剂
    Lithocholic acid是胆汁酸,用作去污剂以溶解脂肪以供吸收。 了解更多
  48. Obeticholic Acid

    Catalog No. A13866
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    FXR 激动剂
    Obeticholic Acid是一种有效的选择性法呢类X受体(FXR)激动剂,EC50为99 nM。 了解更多
  49. LY2562175

    Catalog No. A17016
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    FXR 激动剂
    LY2562175是体外有效的选择性FXR激动剂,其EC50值为193 nM。具有强大的脂质调节特性,可降低临床前物种中的LDL和甘油三酸酯,同时提高HDL。 了解更多
  50. Px-104

    Catalog No. A16999
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    FXR 激动剂
    Px-104,也称为Px-102,是一种潜在的法呢素X受体(FXR)激动剂,可用于治疗非酒精性脂肪肝。 了解更多

产品 1 到 50 共 66个

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