DNA-PK

Catalog No.Inhibitor Name DNA-PKOther
A10726PI-103
**
p110α,p110δ,p110β
A11098NU7441
***
mTOR,PI3K
A10729PIK-75
****
p110α,p110γ,p110δ
A12752NU7026
*
PI3K
A11207PP121
**
PDGFR,Hck,VEGFR
A13224KU-0060648
***
PI3Kδ,PI3Kβ,PI3Kα
A11778Compound 401
*
mTOR,PI3K
A13328ETP-46464
***
ATM, ATR, PI3Kα, mTOR
A15779CC-115
***
mTOR

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

14 个项目

每页

设置升序顺序
  1. PI-103

    Catalog No. A10726
    Quick View
    PI3K 抑制剂
    PI-103是一种有效的,细胞可渗透的,ATP竞争性磷脂酰肌醇3激酶(PI3K)家族抑制剂,对DNA-PK,PI3K(p110α)和mTOR具有选择性。 了解更多
  2. NU-7441 (KU-57788)

    Catalog No. A11098
    Quick View
    DNA-PK 抑制剂
    NU-7441 (KU-57788)是一种有效的选择性DNA依赖性蛋白激酶(DNA-PK)抑制剂。对于DNA-PK,mTOR,PI 3-K,ATM和ATR,IC50值分别为14、1700、5000,> 100000和> 100000 nM。 了解更多
  3. PIK-75

    Catalog No. A10729
    Quick View
    PI3K 抑制剂
    PIK-75是一种p110α抑制剂,IC50值为5.8nM。在p110γ和p110β的效果较差,IC50值为0.076 ?M和1.3 ?M。 了解更多
  4. KU 0060648

    Catalog No. A13224
    Quick View
    DNA-PK 抑制剂
    KU0060648是一种有效且选择性的DNA依赖性蛋白激酶(DNA-PK)抑制剂(IC50 = 8.6 nM);对DNA-PK的选择性是其他PIKK的20-1000倍,并且有60种激酶。KU-0060648可提高HDR效率并衰减NHEJ频率。 了解更多
  5. NU7026

    Catalog No. A12752
    Quick View
    DNA-PK 抑制剂
    NU7026是一种新型的在无细胞试验中IC50为0.23 μM,作用于DNA-PK比作用于PI3K选择性高60倍,对ATM和ATR没有抑制活性。可增强用于治疗白血病的拓扑异构酶II毒物的细胞毒性。 了解更多
  6. CC-115

    Catalog No. A15779
    Quick View
    mTOR/DNA-PK 抑制剂
    CC-115是mTOR/DNA-PK的抑制剂(IC50 = 21/13 nM)。 了解更多
  7. LY3023414

    Catalog No. A16126
    Quick View
    PI3K/mTOR Dual 抑制剂
    LY3023414是从专利WO/2012097039A1(化合物实施例1)中提取的I类PI3K同种型,mTOR和DNA-PK的口服ATP竞争性抑制剂,对Akt1(pT308)的IC50为64.9 nM,42.1 nM,10.6 nM和19.1 nM。),Akt1(pS473),P70S6(pT389),S6RP(pS240/242)。 了解更多
  8. PP121

    Catalog No. A11207
    Quick View
    PI3K 抑制剂
    PP121是一种作用于PDGFR,Hck,mTOR,VEGFR2,Src和Abl的多靶点抑制剂,IC50分别为2 nM,8 nM,10 nM,12 nM,14 nM和18 nM,也抑制DNA-PK,IC50为60 nM。 了解更多
  9. Compound 401

    Catalog No. A11778
    Quick View
    DNA-PK 抑制剂
    Compound 401是一种细胞可渗透的嘧啶-异喹啉酮化合物,可作为有效的,可逆的和ATP竞争的DNA-PK抑制剂(IC50 = 280 nM),选择性是mTOR(IC50 = 5.3μM)的19倍。 了解更多
  10. ETP-46464

    Catalog No. A13328
    Quick View
    ATR 抑制剂
    ETP-46464是一种有效的选择性ATR抑制剂,IC50为25 nM。 了解更多
  11. NU6027

    Catalog No. A14136
    Quick View
    ATR/CDK 抑制剂
    NU6027是一种有效的细胞ATR活性抑制剂(IC(50)=6.7μM),并以ATR依赖的方式增强羟基脲和顺铂的细胞毒性。 了解更多
  12. Nedisertib

    Catalog No. A17055
    Quick View
    DNA-PK 抑制剂
    Nedisertib (M-3814,MSC2490484A)是一种可口服的DNA依赖性蛋白激酶(DNA-PK)抑制剂,具有潜在的抗肿瘤和化学/放射增敏活性。 了解更多
  13. AZD-7648

    Catalog No. A20049
    Quick View
    DNA-PK inhibitor
    AZD-7648 is a potent and selective DNA-PK inhibitor. Anti-tumor activity. 了解更多
  14. (Rac)-Nedisertib

    Catalog No. A21383
    Quick View
    DNA-PK inhibitor
    (Rac)-Nedisertib ((Rac)-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM. 了解更多

14 个项目

每页

设置升序顺序
Rewards