CXCR

Catalog No.Inhibitor Name CXCR1CXCR2CXCR4Other
A10913Plerixafor 8HCl
**
CXCL12-mediated chemotaxis
A13074Plerixafor
**
CXCL12-mediated chemotaxis
A12588WZ811
****
A14209SB225002
***
A16351ATI-2341
*
A14997AMD-070 HCl
***
A15234SCH 563705
****
***
A14209SB225002
***
A11555SCH-527123 (Navarixin)
**
***
A12383Reparixin
****
**
CXCL8
A12596MSX-122
***
A11315AMD 070
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

30 个项目

每页

设置升序顺序
  1. NBI-74330

    Catalog No. A21158
    Quick View
    CXCR3 antagonist
    NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively. 了解更多
  2. AMG 487 S-enantiomer

    Catalog No. A21874
    Quick View
    CXCR3 antagonist
    AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3. 了解更多
  3. SCH 546738

    Catalog No. A21554
    Quick View
    CXCR3 antagonist
    SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. 了解更多
  4. AMG 487

    Catalog No. A21162
    Quick View
    CXCR3 antagonist
    AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. 了解更多
  5. Kynurenic acid sodium

    Catalog No. A20000
    Quick View
    GPR35/CXCR8 agonist
    Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. 了解更多
  6. GPR35 agonist 1

    Catalog No. A12462
    Quick View
    GPR35/CXCR8 agonist
    GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good druggability. 了解更多
  7. SCH 563705

    Catalog No. A15234
    Quick View
    CXCR2/CXCR1 拮抗剂
    SCH 563705是有效的双重CXCR2(IC50 = 1.3 nM)/CXCR1(IC50 = 7.3 nM)拮抗剂。 了解更多
  8. AZD-5069

    Catalog No. A15941
    Quick View
    CXCR2 拮抗剂
    AZD-5069是一种有效的选择性CXCR2拮抗剂,具有抑制COPD患者中性粒细胞向气管迁移的潜能。 了解更多
  9. CXCR2-IN-1

    Catalog No. A12649
    Quick View
    CXCR2 激动剂
    CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3. 了解更多
  10. PS372424

    Catalog No. A19421
    Quick View
    Human CXCR3 拮抗剂
    PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM. 了解更多
  11. Kynurenic acid

    Catalog No. A16581
    Quick View
    GPR35/CXCR8 拮抗剂
    Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. 了解更多
  12. USL311

    Catalog No. A18778
    Quick View
    CXCR4 拮抗剂
    USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. 了解更多
  13. MSX-130

    Catalog No. A17150
    Quick View
    CXCR4 拮抗剂
    MSX-130是CXCR4拮抗剂。 了解更多
  14. NSC-23026

    Catalog No. A17151
    Quick View
    CXCR4 receptor modulator
    NSC-23026是CXCR4受体调节剂。 了解更多
  15. ATI-2341

    Catalog No. A16351
    Quick View
    CXCR4 激动剂
    ATI-2341是针对C-X-C趋化因子受体4型(CXCR4)(EC50 = 194 nM)的pepducin,是一种变构激动剂,可激活抑制性异三聚体G蛋白(Gi),从而促进cAMP生成的抑制并诱导钙动员。 了解更多
  16. UNBS5162

    Catalog No. A15439
    Quick View
    CXCL chemokines 拮抗剂
    UNBS5162是一种新型萘二甲酰亚胺,可降低实验性前列腺癌中CXCL趋化因子的表达。9种癌细胞系的平均抗增殖活性IC50值为17.9 uM;UNBS3157的水解产物。 了解更多
  17. AMD-070 HCl

    Catalog No. A14997
    Quick View
    CXCR4 拮抗剂
    在CXCR4 125I-SDF抑制结合试验中,AMD-070 HCl是一种有效的选择性CXCR4拮抗剂,IC50值为13 nM,抑制T-4型HIV-1(NL4.3株)在MT-4细胞中的复制和PBMC。 了解更多
  18. Reparixin L-lysine salt

    Catalog No. A15219
    Quick View
    CXCL8 receptor 抑制剂
    Reparixin L-lysine salt是CXCL8受体的抑制剂,也抑制CXCR1和CXCR2的活化,已显示在各种损伤模型中减弱了炎症反应。 了解更多
  19. SB225002

    Catalog No. A14209
    Quick View
    CXCR2 拮抗剂
    SB225002是一种有效的选择性CXCR2拮抗剂,IC50为22 nM,可抑制白介素IL-8与CXCR2的结合,选择性是其他测试的7-TMR的150倍以上。 了解更多
  20. SB265610

    Catalog No. A14195
    Quick View
    CXCR2 拮抗剂
    SB265610是CXCR2 (Kd = 2.51 nM)的非肽变构反向激动剂,通过与不同于激动剂结合位点的区域结合来防止受体活化。它不与相关CXCR1受体结合。在体外和高氧诱导肺损伤的大鼠模型中,它已被证明能防止中性粒细胞趋化性。 了解更多
  21. SCH-527123 (Navarixin)

    Catalog No. A11555
    CXCR1/CXCR2 拮抗剂
    SCH-527123 (Navarixin)是人CXCR1和CXCR2受体的强效选择性拮抗剂,IC50分别为42 nM和3 nM。 了解更多
  22. AMD3100 (Plerixafor)

    Catalog No. A13074
    Quick View
    CXCR4 拮抗剂
    AMD3100 (Plerixafor)是用于增殖造血干细胞的免疫刺激剂,并且是用于动员造血干细胞进行移植的趋化因子受体-4拮抗剂。 了解更多
  23. Reparixin

    Catalog No. A12383
    Quick View
    CXCL8/CXCR1/2 抑制剂
    Reparixin是两种CXCL8受体CXCR1/2的有效抑制剂,它抑制CXCR2介导的细胞迁移(IC50 = 100 nM),而它强烈地阻断CXCR1介导的趋化性(IC50 = 1 nM)。 了解更多
  24. SRT3190

    Catalog No. A11577
    Quick View
    SIRT1 activator
    SRT3190是一种强效cxcr2配体。 了解更多
  25. MSX-122

    Catalog No. A12596
    Quick View
    CXCR4 抑制剂
    MSX-122是口服可生物利用的CXCR4抑制剂(IC50 =?10 nM),具有潜在的抗肿瘤和抗病毒活性。CXCR4抑制剂MSX-122与趋化因子受体CXCR4结合,阻止基质衍生因子-1(SDF-1)与CXCR4受体和受体激活结合,这可能导致肿瘤细胞增殖和迁移减少。 了解更多
  26. WZ811

    Catalog No. A12588
    Quick View
    CXCR4 拮抗剂
    WZ811是4型C-X-C趋化因子受体(CXCR4)拮抗剂(EC50 = 0.3 nM)。在体外抑制CXCR4/基质细胞衍生因子1(SDF-1)介导的cAMP调节(EC50 = 1.2 nM)。 了解更多
  27. SRT3109

    Catalog No. A11097
    Quick View
    CXCR2 ligand
    SRT3109是一种CXCR2配体,用于治疗趋化因子介导的疾病和状况。 了解更多
  28. AMD 3465 Hexahydrobromide

    Catalog No. A11953
    Quick View
    CXCR4 拮抗剂
    AMD 3465 Hexahydrobromide是一种有效的选择性CXCR4拮抗剂。 了解更多
  29. AMD 070

    Catalog No. A11315
    Quick View
    CXCR4 拮抗剂
    AMD 070是CXCR4趋化因子受体拮抗剂。 了解更多
  30. Plerixafor 8HCl (DB06809)

    Catalog No. A10913
    Quick View
    CXCR4 拮抗剂
    Plerixafor 8HCl (DB06809)是CXCR4趋化因子受体拮抗剂,作用于CXCR4和CXCL12介导调节的趋化性, IC50分别为44 nM和5.7 nM。 了解更多

30 个项目

每页

设置升序顺序
Rewards