FAK

Catalog No.Inhibitor Name FAKOther
A12580PF-00562271
****
CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11192PF-562271
****
CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11235PF-573228
*
A11507TAE226
**
Insulin Receptor,IGF-1R,c-Met
A11171PF-03814735
*
Aurora A,Aurora B,FLT1
A11142PF-431396
**
A13140PND-1186
****
A11929Defactinib
A15543CEP-37440
**
ALK
A15765GSK2256098
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

16 个项目

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  1. PF-562271

    Catalog No. A11192
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    FAK 抑制剂
    PF-562271是一种有效的,ATP竞争性的,可逆的FAK抑制剂,作用于FAK比作用于Pyk2选择性高10倍左右,比作用于其他蛋白激酶(除了一些CDKs)选择性高100倍以上。 了解更多
  2. PF 573228

    Catalog No. A11235
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    FAK 抑制剂
    PF 573228是一种有效和选择性的粘着斑激酶(FAK)抑制剂(IC50 = 4 nM)。 了解更多
  3. PF-04554878 (Defactinib)

    Catalog No. A11929
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    FAK 抑制剂
    PF-04554878 (Defactinib)是一种新型FAK激酶抑制剂,可降低胰腺神经内分泌肿瘤细胞的生长并诱导其凋亡。 了解更多
  4. NVP-TAE 226

    Catalog No. A11507
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    FAK 抑制剂
    NVP-TAE 226是一种强效FAK抑制剂,IC50为5.5 nM,对pyk2(IC50=3.5 nM)有适度的强效作用;对InsR, IGF-1R, ALK和c-Met的效力降低10-100倍。 了解更多
  5. GSK2256098

    Catalog No. A15765
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    FAK 抑制剂
    GSK2256098是一种粘着斑激酶1(FAK)抑制剂,具有潜在的抗血管生成和抗肿瘤活性。 了解更多
  6. BI-4464

    Catalog No. A18894
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    PTK2/FAK inhibitor
    BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC. 了解更多
  7. PROTAC FAK degrader 1

    Catalog No. A18946
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    FAK degrader
    PROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM. 了解更多
  8. Y15

    Catalog No. A21472
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    FAK inhibitor
    Y15 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. 了解更多
  9. Defactinib

    Catalog No. A21958
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    FAK inhibitor
    Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities. 了解更多
  10. Defactinib hydrochloride

    Catalog No. A22003
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    FAK inhibitor
    Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. 了解更多
  11. PF 431396

    Catalog No. A11142
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    FAK/PYK2 抑制剂
    PF 431396是一种双粘着斑激酶(FAK)和富含脯氨酸的酪氨酸激酶2(PYK2)抑制剂(IC50值分别为2和11 nM)。 了解更多
  12. PF-03814735

    Catalog No. A11171
    Aurora A/B Kinase 抑制剂
    PF-03814735是一种新颖,有效且可逆的Aurora A/B抑制剂,IC50为0.8 nM/5 nM,对Flt3,FAK,TrkA的效力较低,对Met和FGFR1的活性最低。 了解更多
  13. PF-00562271

    Catalog No. A12580
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    FAK 抑制剂
    PF-00562271是PF-562271的苯磺酸盐,是一种有效的,ATP竞争性,可逆的FAK和Pyk2抑制剂,IC50分别为1.5 nM和14 nM。 了解更多
  14. PND-1186

    Catalog No. A13140
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    FAK 抑制剂
    PND-1186是一种强效fak抑制剂,ic50为1.5 nm。 了解更多
  15. PF-4618433

    Catalog No. A13461
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    PYK2/FAK 抑制剂
    PF-4618433与原型BIRB796相比,PF-4618433显示出PYK2效价提高、p38活性降低和总体选择性优越。 了解更多
  16. CEP-37440

    Catalog No. A15543
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    FAK/ALK 抑制剂
    CEP-37440是一种新型的高效选择性FAK/ALK双重抑制剂,IC50为2.3 nM(FAK)和120 nM(ALK细胞在50%人血浆中的IC50。 了解更多

16 个项目

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