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Neuronal Signaling

29 个项目

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  1. ARN2966
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    ARN2966

    Catalog No. A21016
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    APP expression modulator
    ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. 了解更多
  2. E 2012
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    E 2012

    Catalog No. A11393
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    gamma-secretase modulator
    E 2012是γ-secretase抑制剂。 了解更多
  3. gamma-secretase modulator 3
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    gamma-secretase modulator 3

    Catalog No. A15090
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    gamma-secretase modulator
    gamma-secretase modulator 3 是γ-分泌酶调节剂。 了解更多
  4. TC-E 5006
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    TC-E 5006

    Catalog No. A13217
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    Gamma-secretase modulator
    TC-E 5006是一种γ-分泌酶调节剂。在体外（EC50 = 390 nM）和体内降低Aβ42水平。 了解更多
  5. gamma-secretase modulator 1
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    gamma-secretase modulator 1

    Catalog No. A11425
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    Gamma-secretase modulator
    gamma-secretase modulator 1是γ-分泌酶调节剂，γ-分泌酶调节剂1可用于阿尔茨海默病。 了解更多
  6. Compound W
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    Compound W

    Catalog No. A15296
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    Gamma-secretase modulator
    Compound W是一种γ-分泌酶抑制剂，已被证明可以降低分泌的Aβ42和Nβ25的水平。 了解更多
  7. CHF5074
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    CHF5074

    Catalog No. A16214
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    γ-Secretase modulator
    CHF5074是新型的γ-分泌酶调节剂，可减少Aβ42和Aβ40的分泌，IC50分别为3.6和18.4 uM。 了解更多
  8. gamma-secretase modulator 2
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    gamma-secretase modulator 2

    Catalog No. A11427
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    Gamma-secretase modulator
    Gamma-secretase modulator 2是γ-secretase调节剂，可用于阿尔兹海默。 了解更多
  9. Flurizan
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    Flurizan

    Catalog No. A12433
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    gamma-secretase modulator
    Flurizan是一种非甾体抗炎药（NSAID），可抑制γ-分泌酶的活性。 了解更多
  10. BPN-15606
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    BPN-15606

    Catalog No. A18681
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    γ-secretase modulator
    BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. 了解更多
  11. NGP-555
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    NGP-555

    Catalog No. A17051
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    γ-Secretase Modulator
    NGP-555是一种γ-分泌酶调节剂，具有选择性机制，可减少Abeta 42，同时提高较短的Abeta形式，例如Abeta 37和38。 了解更多
  12. Basmisanil
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    Basmisanil

    Catalog No. A21321
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    GABAAα5 modulator
    Basmisanil is a highly selective GABAAα5 negative allosteric modulator. 了解更多
  13. NS11394
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    NS11394

    Catalog No. A21425
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    GABA(A) receptor modulator
    NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors. 了解更多
  14. CTP354
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    CTP354

    Catalog No. A15939
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    GABA(A) modulator
    CTP354是一种新型的氘化亚型选择性GABA（A）调节剂。 了解更多
  15. Indiplon
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    Indiplon

    Catalog No. A13769
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    GABAA receptor modulator
    Indiplon是吡唑并嘧啶，可作为GABAA受体的高亲和力正变构调节剂，以剂量依赖和可逆的方式增强GABA活化的氯离子电流。 了解更多
  16. Lorediplon
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    Lorediplon

    Catalog No. A13449
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    GABAA receptor modulator
    Lorediplon 是一种新型的非苯二氮卓类催眠药，作为GABAA受体调节剂。 了解更多
  17. GNE 0723
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    GNE 0723

    Catalog No. A12757
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    NMDAR modulator
    GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively. 了解更多
  18. GLYX-13 (Rapastinel)
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    GLYX-13 (Rapastinel)

    Catalog No. A13576
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    NMDAR modulator
    GLYX-13 (Rapastinel)是NMDA受体甘氨酸位点的选择性弱部分激动剂。 了解更多
  19. Rapacuronium bromide
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    Rapacuronium bromide

    Catalog No. A21119
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    mAChR modulator
    Rapacuronium bromide is an allosteric modulator of muscarinic acetylcholine receptor (mAChR). 了解更多
  20. MK7622
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    MK7622

    Catalog No. A12835
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    M1 调节剂
    MK7622是毒蕈碱M1受体阳性变构调节剂。 了解更多
  21. (Rac)-VU 6008667
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    (Rac)-VU 6008667

    Catalog No. A21939
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    mAChR M5 negative allosteric modulator
    (Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration. 了解更多
  22. A-867744
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    A-867744

    Catalog No. A11290
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    modulator of α7 nAChRs
    A-867744是α7烟碱乙酰胆碱受体的新型正变构调节剂。 了解更多
  23. (-)-(S)-B-973B
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    (-)-(S)-B-973B

    Catalog No. A18761
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    α7 nAChR modulator
    -)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity. 了解更多
  24. CCMI
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    CCMI

    Catalog No. A21534
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    α7 nAChR-positive allosteric modulator
    CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. 了解更多
  25. PNU-120596
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    PNU-120596

    Catalog No. A11203
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    Nicotinic (α7) Receptor Modulator
    PNU-120596是α7神经元烟碱型乙酰胆碱受体的正变构调节剂。 了解更多
  26. Tebanicline hydrochloride
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    Tebanicline hydrochloride

    Catalog No. A21918
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    nAChR modulator
    Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. 了解更多
  27. BNC375
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    BNC375

    Catalog No. A18503
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    α7 nAChR Modulator
    BNC375 is a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs. 了解更多
  28. GW791343 trihydrochloride
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    GW791343 trihydrochloride

    Catalog No. A21204
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    P2X7 allosteric modulator
    GW791343 3Hcl is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). 了解更多
  29. GW791343 HCl
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    GW791343 HCl

    Catalog No. A11107
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    P2X7 modulator
    GW791343 HCl充当人P2X7的负变构调节剂（pIC50 = 6.9-7.2）和大鼠P2X7的正变构调节剂。 了解更多

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