Smoothened Receptors

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  1. LY2940680 (Taladegib)

    Catalog No. A11048
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    SMO 拮抗剂
    LY2940680 (Taladegib)已显示可影响由Hedgehog(Hh)蛋白引发的癌细胞信号通路。 了解更多
  2. LDE225 Diphosphate

    Catalog No. A12774
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    Smoothened 抑制剂
    LDE225 Diphosphate 是一种具有潜在抗肿瘤活性的口服生物利用小分子平滑(Smo)拮抗剂。抑制Hedgehog (Hh)信号通路,无细胞试验中IC50分别为1.3 nM (小鼠)和2.5 nM(人)。 了解更多
  3. PF-5274857

    Catalog No. A12775
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    Smoothened 抑制剂
    PF-5274857是一种新型Smo拮抗剂,它以4.6±1.1 nmol/L的K(i)特异性结合Smo,并以2.7±1.4 nmol/L的IC(50)完全阻断下游基因Gli1的转录活性。在细胞中。 了解更多
  4. BMS-833923 (XL-139)

    Catalog No. A13204
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    Smoothened 抑制剂
    BMS-833923 (XL-139)是一种生物可利用的小分子SMO(平滑)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  5. Glasdegib (PF-04449913)

    Catalog No. A13881
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    Smoothened 抑制剂
    PF-04449913是有效且口服可生物利用的平滑化抑制剂。 了解更多
  6. SAG

    Catalog No. A13627
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    SMO 激动剂
    SAG是一种含氯苯并噻吩的化合物,可作为SMO激动剂(EC50 = 3 nM),但在高浓度(> 1 uM)下抑制刺猬信号。 了解更多
  7. Jervine

    Catalog No. A16221
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    SMO 抑制剂
    Jervine是天然存在的甾体生物碱,可通过阻断声波刺猬(Shh)信号传导而引起Cyclopia。抑制Smo。 了解更多
  8. ALLO-2

    Catalog No. A18698
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    Smo mutant antagonist
    ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. 了解更多
  9. Saridegib

    Catalog No. A12966
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    Smo inhibitor
    Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. 了解更多
  10. LEQ506

    Catalog No. A20941
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    Smo inhibitor
    LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. 了解更多
  11. SAG hydrochloride

    Catalog No. A21678
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    Smo receptor agonist
    SAG (hydrochloride) is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with a Kd of 59 nM. 了解更多
  12. 20(S)-Hydroxycholesterol

    Catalog No. A21850
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    Smo allosteric activator
    20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells. 了解更多
  13. MRT-83

    Catalog No. A21020
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    Smo antagonist
    MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling. 了解更多
  14. LDE225 (NVP-LDE225, Sonidegib)

    Catalog No. A10520
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    Smo 拮抗剂
    LDE225 (NVP-LDE225)是一种强效、选择性和口服生物可利用的平滑(SMO)拮抗剂,通过平滑受体(SMO)的拮抗作用抑制hedgehog (Hh)信号通路。 了解更多

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