Membrane Transporters/Ion Channels

36 个项目

每页

设置升序顺序
  1. PF 3716556

    Catalog No. A11408
    Quick View
    ATPase 拮抗剂
    PF 3716556是H+,K+-ATPase酶抑制剂(在人类重组离子渗漏试验中PIC50 = 6)。 了解更多
  2. TTA-Q6

    Catalog No. A21360
    Quick View
    T-type Ca2+ channel antagonist
    TTA-Q6 is a selective T-type Ca2+ channel antagonist, used in the neurological disease. 了解更多
  3. TTA-Q6(isomer)

    Catalog No. A21724
    Quick View
    T-type Ca2+ channel antagonist
    TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca2+ channel antagonist. 了解更多
  4. Aranidipine

    Catalog No. A18291
    Quick View
    Calcium channel antagonist
    Aranidipine (MPC1304) is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects. 了解更多
  5. Barnidipine

    Catalog No. A21940
    Quick View
    L-type calcium antagonist
    Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors. 了解更多
  6. Orphenadrine citrate

    Catalog No. A11712
    Quick View
    NMDA receptor 拮抗剂
    Orphenadrine柠檬酸盐是NMDA受体拮抗剂,Ki为6.0μM,还是HERG钾离子通道阻断剂。 了解更多
  7. Proparacaine HCl

    Catalog No. A11715
    Quick View
    Voltage-gated sodium channels 拮抗剂
    Proparacaine HCl是一种电压门控钠通道拮抗剂,ED50为3.4 mM。 了解更多
  8. Mitiglinide calcium

    Catalog No. A11884
    Quick View
    KATP channel 拮抗剂
    Mitiglinide calcium是一种降血糖药物,通过关闭胰腺β细胞中的ATP敏感K+通道来刺激胰岛素分泌。 了解更多
  9. Tezampanel

    Catalog No. A15259
    Quick View
    AMPA 拮抗剂
    Tezampanel是AMPA和离子型谷氨酸受体的海藻酸盐家族的拮抗剂,对海藻酸盐受体的GluR5亚型具有选择性。 了解更多
  10. YM90K hydrochloride

    Catalog No. A15495
    Quick View
    AMPA 拮抗剂
    YM90K hydrochloride是一种选择性AMPA受体拮抗剂,在局部缺血后给药后,可延迟整体缺血模型中的神经元死亡和局部缺血模型中的脑梗塞。 了解更多
  11. Talampanel

    Catalog No. A15515
    Quick View
    AMPA/kainate receptor 拮抗剂
    Talampanel是AMPA受体的非竞争性拮抗剂,具有抗癫痫活性。 了解更多
  12. CP 465022 hydrochloride

    Catalog No. A13321
    Quick View
    AMPA 拮抗剂
    CP 465022 hydrochloride是一种选择性的非竞争性AMPA拮抗剂,在大鼠皮质神经元中的IC50为25 nM,显示出有效的抗惊厥活性。 了解更多
  13. SYM2206

    Catalog No. A20843
    Quick View
    AMPA receptor antagonist
    SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist. 了解更多
  14. Fanapanel

    Catalog No. A21200
    Quick View
    AMPA/kainate antagonist
    Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. 了解更多
  15. Naspm trihydrochloride

    Catalog No. A21437
    Quick View
    CP-AMPA receptors antagonist
    Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. 了解更多
  16. Fanapanel hydrate

    Catalog No. A21668
    Quick View
    AMPA/kainate antagonist
    Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. 了解更多
  17. Philanthotoxin 74 dihydrochloride

    Catalog No. A21739
    Quick View
    AMPAR antagonist
    Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. 了解更多
  18. Naspm

    Catalog No. A21919
    Quick View
    AMPA (CP-AMPA) receptors antagonist
    Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. 了解更多
  19. GYKI-52466 dihydrochloride

    Catalog No. A10444
    Quick View
    AMPA and Kainate 拮抗剂
    GYKI-52466 dihydrochloride是选择性非竞争性AMPA受体拮抗剂(对于AMPA、红藻氨酸和AMPA诱导的反应,IC50值分别为10-20、~ 450和> > 50 μM)。 了解更多
  20. NBQX

    Catalog No. A13109
    Quick View
    AMPA Receptor 拮抗剂
    NBQX是一种有效,选择性和竞争性的AMPA受体拮抗剂。 了解更多
  21. DNQX

    Catalog No. A13882
    Quick View
    NMDA receptor 拮抗剂
    DNQX是一种非N-甲基-D-天冬氨酸(非NMDA)受体复合物拮抗剂。 了解更多
  22. CNQX

    Catalog No. A16109
    Quick View
    AMPA/kainate 拮抗剂
    CNQX是一种竞争性的非NMDA谷氨酸受体拮抗剂(AMPA和海藻酸酯受体的IC50分别为0.3和1.5 uM,而NMDA受体的IC50 = 25 uM)。 了解更多
  23. CNQX disodium salt

    Catalog No. A16110
    Quick View
    AMPA/kainate 拮抗剂
    CNQX disodium salt,AMPA/海藻酸酯拮抗剂CNQX(GLXC-11053)的水溶性形式。 了解更多
  24. GYKI53655 Hydrochloride

    Catalog No. A17032
    Quick View
    AMPA 拮抗剂
    GYKI53655 Hydrochloride是一种非竞争性AMPA和海藻酸酯受体拮抗剂。 了解更多
  25. CFM-2

    Catalog No. A21930
    Quick View
    non-competitive AMPAR antagonist
    CFM-2 is a selective non-competitive AMPAR antagonist. 了解更多
  26. Becampanel

    Catalog No. A21194
    Quick View
    AMPA antagonist
    Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent. 了解更多
  27. AMG-333

    Catalog No. A17182
    Quick View
    TRPM8 拮抗剂
    AMG-333是有效的选择性TRPM8拮抗剂,IC50为13 nM。 了解更多
  28. AMG2850

    Catalog No. A19445
    Quick View
    TRPM8 antagonist
    AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist. 了解更多
  29. RQ-00203078

    Catalog No. A15830
    Quick View
    TRPM8 拮抗剂
    RQ-00203078是一种高度选择性,有效且可口服的TRPM8拮抗剂(大鼠和人类通道的IC50值分别为5.3和8.3 nM),对TRPM8的选择性是TRPV4,TRPV1和TRPA1的> 350倍。 了解更多
  30. SB-705498

    Catalog No. A11143
    Quick View
    TRPV1 拮抗剂
    SB-705498是有效,选择性和口服生物利用的TRPV1拮抗剂,抑制TRPV1的Capsaicin,酸和热激活,IC50分别为3 nM, 0.1 nM和6 nM,该作用具有一定的电压依赖性,作用于TRPV1比作用于TRPM8选择性高100倍以上。 了解更多
  31. AMG517

    Catalog No. A12727
    Quick View
    TRPV1 拮抗剂
    AMG 517是有效的选择性TRPV1拮抗剂。 了解更多
  32. A-889425

    Catalog No. A13497
    Quick View
    TRPV1 receptor 拮抗剂
    A-889425是选择性TRPV1受体拮抗剂。A-889425阻断TRPV1通道,IC50为335 nM(大鼠)和34 nM(人)。 了解更多
  33. Mavatrep

    Catalog No. A15778
    TRPV1 拮抗剂
    Mavatrep是生物利用的TRPV1拮抗剂(Ki = 6.5 nM),对CYP亚型3A4、1A2和2D6的酶活性(IC50> 25μM)影响很小。 了解更多
  34. SB366791

    Catalog No. A15857
    Quick View
    TRPV1 receptor 拮抗剂
    SB-366791是新颖,有效且选择性的肉桂酰胺TRPV1拮抗剂。 了解更多
  35. A-1165442

    Catalog No. A21516
    Quick View
    TRPV1 antagonist
    A-1165442 is a potent, competitive and orally available TRPV1 antagonist with an IC50 of 9 nM for human TRPV1. 了解更多
  36. JNJ-17203212

    Catalog No. A12766
    Quick View
    TRPV1 antagonist
    NJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. 了解更多

36 个项目

每页

设置升序顺序
Rewards