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Inhibitory Selectivity
| Catalog No. | Inhibitor Name | HIF | HIF1 | Other |
|---|---|---|---|---|
| A15530 | FG-2216 | **** | **** | |
| A15359 | KC7F2 | ** | ** | |
| A11237 | Roxadustat | |||
| A10012 | 2-Methoxyestradiol | Microtubule Associated | ||
| A14319 | PX-478 2HCl | |||
| A12978 | BAY 87-2243 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
18 个项目
每页
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A15358 |
Chetomin
|
HIF 抑制剂 |
Chetomin is reported to be an antibiotic metabolite of Chaetomium spp. which contains bacteriostatic effects on Gram-positive bacteria.
|
A15359 SALE |
KC7F2
|
HIF 抑制剂 |
KC7F2 is an inhibitor of HIF-1?? protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K).
|
A15360 |
ML 228
|
HIF activator |
ML-228 is an activator of the HIF signaling pathway, as demonstrated by HIF response element (HRE) reporter assay, HIF-1?? nuclear translocation assay, and increased VEGF expression.
|
A14021 |
Echinomycin |
HIF-1?? 抑制剂 |
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription
|
A14367 |
Oroxylin A |
- |
Oroxylin A is an O-methylated flavone, It has demonstrated activity as a dopamine reuptake inhibitor and is also a negative allosteric modulator of the benzodiazepine site of the GABAA receptor.
|
A15530 SALE |
FG-2216 |
HIF-prolyl hydroxylase 抑制剂 |
FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo,
|
A15793 SALE |
JNJ-42041935
|
HIF-PHD 抑制剂 II |
JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
|
A12671 SALE |
GSK1278863 (Daprodustat) |
HIF-prolyl hydroxylase 抑制剂 |
GSK1278863 is a novel HIF-prolyl hydroxylase inhibitor.
|
A15895 |
DASA-58 |
PKM2 Activator |
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
|
A14404 SALE |
Molidustat |
HIF-PH 抑制剂 |
Molidustat is a novel inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) which stimulates erythropoietin (EPO) production and the formation of red blood cells.
|
A14319 SALE |
PX-478 HCl |
HIF-1alpha 抑制剂 |
PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity.
|
A12978 SALE |
BAY 87-2243 |
HIF 抑制剂 |
BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
|
A12921 |
HIF-C2 |
HIF-2 抑制剂 |
HIF-C2 is a potent and selective allosteric inhibitor of hypoxia inducible factor-2 (HIF-2)
|
A12883 |
FM19G11 |
HIF?? 抑制剂 |
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), which are transcription factors that respond to changes in available oxygen in the cellular environment.
|
A11924 SALE |
IOX 2 |
HIF-PHD 抑制剂 |
IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.
|
A11237 SALE |
FG-4592 (Roxadustat) |
HIF-PHs 抑制剂 |
FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.
|
A10012 SALE |
2-Methoxyestradiol |
Apoptotic, antiproliferative and antiangiogenic agent |
2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.
|
A16181 |
HIF-2a Translation Inhibitor |
HIF-2a translation 抑制剂 |
HIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).
|
18 个项目
每页
