BTK

Catalog No.Inhibitor Name BTKOther
A11020Ibrutinib
****
BLK,Bmx,FGR
A13202AVL-292
****
YES,c-Src,BRK
A13233CNX-774
***
A15558ONO-4059 analogue
**
A16261LFM-A13
*
A12535RN486
**
A11348CGI1746
***
A12706GDC-0834
**
A15008AVL-292 benzenesulfonate
****
YES,c-Src,BRK
A15824ACP-196 (Acalabrutinib)
**
A15976Olmutinib (HM71224)
***
A16262PCI 29732
**
A16263QL47
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Poseltinib (HM71224, LY3337641)

    Catalog No. A19450
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    BTK inhibitor
    Poseltinib, an orally active, selective and irreversible Bruton??s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. 了解更多
  2. QL47

    Catalog No. A16263
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    BTK 抑制剂
    QL47是一种有效,选择性和不可逆的BTK激酶抑制剂,IC50为7 nM。 了解更多
  3. PCI 29732

    Catalog No. A16262
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    BTK 抑制剂
    PCI 29732是一种选择性且不可逆的Btk抑制剂,在基于FRET的生化酶检测中,IC50为8.2 nM。 了解更多
  4. LFM-A13

    Catalog No. A16261
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    BTK 抑制剂
    LFM-A13是有效且选择性的Btk抑制剂,IC50为17.2 uM;也抑制PLK3,IC50为7.2 uM。 了解更多
  5. Btk inhibitor 1

    Catalog No. A16260
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    BTK 抑制剂
    Btk inhibitor 1 是作为Btk激酶抑制剂的吡唑并[3,4-d]嘧啶衍生物。 了解更多
  6. Olmutinib (HM61713)

    Catalog No. A15976
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    BTK 抑制剂
    Olmutinib (HM61713)是Bruton酪氨酸激酶(BTK)的有效小分子抑制剂。 了解更多
  7. CHMFL-BTK-01

    Catalog No. A12538
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    BTK inhibitor
    CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation. 了解更多
  8. ONO-4059

    Catalog No. A15558
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    BTK 抑制剂
    ONO-4059是一种高效和选择性的BTK抑制剂。 了解更多
  9. PCI-33380

    Catalog No. A12270
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    BTK inhibitor
    PCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe). 了解更多
  10. Ibrutinib Racemate

    Catalog No. A18022
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    Btk inhibitor
    Ibrutinib Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM. 了解更多
  11. (R)-Zanubrutinib

    Catalog No. A21342
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    BTK inhibitor
    (R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor. 了解更多
  12. Btk inhibitor 1 (R enantiomer)

    Catalog No. A21861
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    BTK inhibitor
    Btk inhibitor 1 R enantiomer (Ibrutinib analog) (Compound 14) is a covalent and irreversible Bruton??s tyrosine kinase (BTK) inhibitor and can be used in synthesis of Ibrutinib and ibrutinib-based activity-based probes (ABPs). 了解更多
  13. Btk inhibitor 1 R enantiomer hydrochloride

    Catalog No. A21865
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    BTK inhibitor
    Btk inhibitor 1 R enantiomer hydrochloride (Ibrutinib analog hydrochloride) (Compound 14) is a covalent and irreversible Bruton??s tyrosine kinase (BTK) inhibitor and can be used in synthesis of Ibrutinib and ibrutinib-based activity-based probes (ABPs). 了解更多
  14. GDC-0834

    Catalog No. A21243
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    BTK inhibitor
    GDC-0834 is a potent and selective BTK inhibitor. 了解更多
  15. Tirabrutinib

    Catalog No. A21019
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    BTK inhibitor
    Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM. 了解更多
  16. MT-802

    Catalog No. A18589
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    BTK degrader
    MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL). 了解更多
  17. PF-06250112

    Catalog No. A18612
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    BTK 抑制剂
    PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. 了解更多
  18. Vecabrutinib

    Catalog No. A17189
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    BTK 抑制剂
    Vecabrutinib是有效的,非共价的,可逆的BTK抑制剂,可抑制BCR途径的信号传导。 了解更多
  19. Btk inhibitor 2

    Catalog No. A17057
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    Btk 抑制剂
    Btk inhibitor 2 是Bruton酪氨酸激酶(BTK)抑制剂。 了解更多
  20. BMS-935177

    Catalog No. A16905
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    BTK 抑制剂
    BMS-935177是一种有效的BTK抑制剂,具有多种激酶改善的激酶选择性和优异的口服暴露性。应该在自身免疫性疾病中提供有用的临床疗效。 了解更多
  21. GDC0853

    Catalog No. A16339
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    BTK 抑制剂
    GDC0853是有效的口服BTK抑制剂。 了解更多
  22. ACP-196 (Acalabrutinib)

    Catalog No. A15824
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    Btk 抑制剂
    ACP-196是Bruton酪氨酸激酶(BTK)抑制剂,具有潜在的抗肿瘤活性。它抑制BTK的活性并阻止B细胞抗原受体(BCR)信号传导途径的激活。 了解更多
  23. AVL-292 benzenesulfonate

    Catalog No. A15008
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    BTK 抑制剂
    AVL-292 benzenesulfonate是一种共价,高选择性,口服活性的Btk小分子抑制剂,IC50值为0.5 nM,选择性是其他测定激酶的1400倍以上。 了解更多
  24. RN486

    Catalog No. A12535
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    BTK 抑制剂
    RN486是一种布鲁顿酪氨酸激酶(Btk)抑制剂。 了解更多
  25. CNX-774

    Catalog No. A13233
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    BTK 抑制剂
    CNX-774是有效的Btk抑制剂(IC50 <1 nM)。 了解更多
  26. AVL-292

    Catalog No. A13202
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    Btk 抑制剂
    AVL-292是一种高选择性共价Btk抑制剂。 了解更多
  27. GDC-0834 Racemate

    Catalog No. A12706
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    BTK 抑制剂
    GDC-0834 Racemate是一种有效且选择性的Bruton酪氨酸激酶(BTK)抑制剂,被研究用作类风湿关节炎的潜在治疗剂。 了解更多
  28. CGI1746

    Catalog No. A11348
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    BTK 抑制剂
    CGI1746是具有新结合模式的小分子Btk抑制剂化学型,可稳定无活性的非磷酸化酶构象。 了解更多
  29. PCI-32765 (Ibrutinib)

    Catalog No. A11020
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    Bruton tyrosine kinase 抑制剂
    PCI-32765 (Ibrutinib)是Bruton酪氨酸激酶(BTK)的口服生物利用小分子抑制剂,具有潜在的抗肿瘤活性。对Bmx,CSK,FGR,BRK及HCK适度有效,对EGFR,Yes,ErbB2,JAK3等作用效果较弱。 了解更多

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