Syk

Catalog No.Inhibitor Name SykOther
A10769R406 besylate
**
Flt3
A10770R406 (Tamatinib)
**
Flt3
A10771R788 Disodium
**
A12731PRT062607 HCl
****
FGR,MLK1,YES
A11926Fostamatinib
**
Adenosine A3 receptor,Adenosine transporter,Monoamine transporter
A16240MNS
*
p97,Src
A15524PRT-060318
****
A13884Entospletinib
***
A11320BAY-61-3606
***
A12162Piceatannol
Lyn,PKA,PKC
A11952P505-15 (PRT062607, BIIB057)
****
FGR, MLK1
A14161R112
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. TAK-659 hydrochloride

    Catalog No. A21885
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    Syk inhibitor
    TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM. 了解更多
  2. Fostamatinib disodium hexahydrate

    Catalog No. A21873
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    Syk inhibitor
    Fostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. 了解更多
  3. Lanraplenib

    Catalog No. A12959
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    SYK inhibitor
    Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. 了解更多
  4. RO9021

    Catalog No. A16686
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    ATP-competitive SYK inhibitor
    RO9021 is an orally bioavailable, novel ATP-competitive inhibitor of SYK, with an average IC50 of 5.6 nM. 了解更多
  5. R112

    Catalog No. A14161
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    Syk 抑制剂
    R112是Syk抑制剂。R112抑制了肥大细胞中抗IgE交联诱导的脱颗粒,并阻断了白三烯C4的产生和所有促炎细胞因子的测试。 了解更多
  6. PRT-060318

    Catalog No. A15524
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    Syk 抑制剂
    PRT-060318是一种新型的酪氨酸激酶Syk选择性抑制剂,可用于HIT治疗。 了解更多
  7. BAY 61-3606 dihydrochloride

    Catalog No. A15017
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    Syk 抑制剂
    BAY 61-3606 dihydrochloride是一种有效的Syk激酶抑制剂(Ki = 7.5 nM)。 了解更多
  8. PRT 062070 (Cerdulatinib)

    Catalog No. A14147
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    Dual Syk and JAK 抑制剂
    PRT 062070 (Cerdulatinib)是一种新型的口服双脾酪氨酸激酶(Syk)和janus激酶(JAK)抑制剂。Cerdulatinib优先抑制各种细胞类型中JAK1和JAK3依赖性细胞因子介导的信号传导和功能性反应。 了解更多
  9. P505-15 (PRT062607, BIIB057)

    Catalog No. A11952
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    Syk 抑制剂
    P505-15 (PRT062607,BIIB057)是一种新型的,高度选择性的,Syk抑制剂(SYK IC(50)= 1 nM),具有比SYK活性至少高80倍的抗SYK活性。 了解更多
  10. R788 (Fostamatinib)

    Catalog No. A11926
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    Syk 抑制剂
    R788 (Fostamatinib)是重要的脾酪氨酸激酶(Syk)抑制剂,显示出对激酶介导的IgG Fcγ受体信号转导的功效。 了解更多
  11. BAY 61-3606

    Catalog No. A11320
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    Syk 抑制剂
    BAY 61-3606是一种细胞可渗透的咪唑并嘧啶化合物,可作为Syk酪氨酸激酶活性的有效,ATP竞争性,可逆和高度选择性抑制剂,而对Btk,Fyn,Itk,Lyn和Src无抑制作用。 了解更多
  12. PRT062607 HCL

    Catalog No. A12731
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    Syk 抑制剂
    PRT2607,也称为PRT062607,P505-15和BIIB057,是一种新型,高度选择性且口服可生物利用的小分子SYK抑制剂(SYK IC(50)= 1 nM),具有至少80倍的抗SYK活性 大于对其他激酶的亲和力。 了解更多
  13. GS-9973 (Entospletinib)

    Catalog No. A13884
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    Syk 抑制剂
    GS-9973 (Entospletinib)是一种口服酪氨酸激酶(Syk)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  14. Piceatannol

    Catalog No. A12162
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    Syk 抑制剂
    Piceatannol是一种抗炎,免疫调节和抗增殖剂。抑制p56lck和syk蛋白酪氨酸激酶,并抑制TNF诱导的NF-κB活化和基因表达。 了解更多
  15. MNS

    Catalog No. A16240
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    Src/Syk 抑制剂
    MNS是Src和Syk酪氨酸激酶的有效和选择性抑制剂。 了解更多
  16. R935788 (Fostamatinib disodium, R788)

    Catalog No. A10771
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    Syk 抑制剂
    R935788 (Fostamatinib disodium,R788)是一种有效的口服Syk抑制剂,可通过阻断抗原依赖性B细胞受体信号传导来抑制CLL的Eμ-TCL1转基因小鼠模型中的肿瘤生长。 了解更多
  17. R406 (Tamatinib)

    Catalog No. A10770
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    Syk 抑制剂
    R406 (Tamatinib)是一种口服酪氨酸激酶抑制剂,IC50为41 nM。对Syk抑制作用强,但是不抑制Lyn,对Flt3的作用比对Syk低5倍。 了解更多
  18. R406 besylate

    Catalog No. A10769
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    Syk 抑制剂
    R406 besylate是一种口服酪氨酸激酶抑制剂,IC50为41 nM。对Syk抑制作用强,但是不抑制Lyn,对Flt3的作用比对Syk低5倍。 了解更多

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