Trk Receptors

Catalog No.Inhibitor Name TrkATrkBTrkCTrk receptorOther
A11059BMS-754807
**
***
Insulin Receptor,IGF-1R,Met
A16238GW441756
****
A16259Sitravatinib (MGCD516)
***
*
DDR2,EPHA3,Axl
A13877ANA-12
*
A13730GNF-5837
**
*
**
A15801Entrectinib (RXDX-101)
ALK,ROS1
A10053Tyrphostin AG 879
*
Her2
A10715Danusertib (PHA-739358)
*
Aurora A, Abl, RET, FGFR1, Aurora C, Aurora B
A15494LM22A-4
*
A15974Larotrectinib (LOXO-101) sulfate
A161237,8-Dihydroxyflavone

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Danusertib (PHA-739358)

    Catalog No. A10715
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    Aurora 抑制剂
    Danusertib (PHA-739358)是Aurora A/B/C的Aurora激酶抑制剂,在无细胞分析中的IC50为13 nM/79nM/61 nM,对Abl,TrkA,c-RET和FGFR1以及更低的浓度具有中等效力 对Lck,VEGFR2/3,c-Kit,CDK2等有效。 了解更多
  2. BMS-754807

    Catalog No. A11059
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    IGF-1R 抑制剂
    BMS-754807是一种有效的,口服活性生长因子1受体/胰岛素受体家族靶向的激酶抑制剂。 了解更多
  3. GNF 5837

    Catalog No. A13730
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    TRK 抑制剂
    GNF-5837是一种有效的,选择性的,口服可生物利用的pan-TRK抑制剂,可在源自表达TRKA和NGF的RIE细胞的小鼠异种移植模型中抑制肿瘤生长。 了解更多
  4. ANA-12

    Catalog No. A13877
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    TrkB 抑制剂
    ANA-12是TrkB受体拮抗剂,具有2位作用模式,可非竞争性地阻止BDNF激活。 了解更多
  5. Entrectinib

    Catalog No. A15801
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    TRK, ROS1, ALK 抑制剂
    Entrectinib,也称为RXDX-101和NMS-E628,是TrkA,TrkB和TrkC以及ROS1和ALK的小分子抑制剂,具有很高的效力和选择性。 了解更多
  6. LOXO-101 (ARRY-470, Larotrectinib)

    Catalog No. A15974
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    TRK 抑制剂
    LOXO-101 (ARRY-470,Larotrectinib)是TRKA,TRKB和TRKC的口服生物有效,有效,ATP竞争性抑制剂。 了解更多
  7. GW 441756

    Catalog No. A16238
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    TrkA 抑制剂
    GW 441756是一种特异的肌球蛋白相关激酶A(TrkA)抑制剂,IC50值为2 nM。对c-Raf1和CDK2几乎没有活性。 了解更多
  8. LOXO-101 sulfate

    Catalog No. A16239
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    TRK 抑制剂
    LOXO-101 sulfate是一种小分子,设计用于阻断TRK家族的ATP结合位点,对TRKA,TRKB和TRKC激酶具有2至20 nM的细胞效力。 了解更多
  9. Tyrphostin AG 879

    Catalog No. A10053
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    HER2 抑制剂
    Tyrphostin AG 879是神经生长因子(NGF)TrkA酪氨酸激酶活性的抑制剂。 了解更多
  10. AZ 23

    Catalog No. A12666
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    TrkA 抑制剂
    AZ 23是一种有效的选择性酪氨酸激酶Trk抑制剂,对TrkA和TrkB的IC50分别为2和8 nM。 了解更多
  11. Sitravatinib (MGCD516)

    Catalog No. A16259
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    RTK 抑制剂
    Sitravatinib是一种新型小分子抑制剂,靶向多种参与驱动肉瘤细胞生长的RTK。 了解更多

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