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￥ 0.00 Cell Metabolism
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PX20606 trans-isomer
Catalog No. A16997 FXR 激动剂PX20606 trans-isomer在小鼠和猴子中诱导高密度脂蛋白介导的跨肝胆固醇外流，并预防胆固醇酯转移蛋白转基因低密度脂蛋白受体(-/-)mice的动脉粥样硬化。 了解更多 -
Mutant IDH1 inhibitor
Catalog No. A21150 mutant IDH1 R132H inhibitorMutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM. 了解更多 -
Mutant IDH1-IN-2
Catalog No. A21339 IDH inhibitorMutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay. 了解更多 -
Mutant IDH1-IN-1
Catalog No. A21359 mutant-selective IDH1 inhibitorMutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively. 了解更多 -
AGI-5198 (IDH-C35)
Catalog No. A12902 -
AG-120 (Ivosidenib)
Catalog No. A14386 -
Vorasidenib
Catalog No. A16908 IDH1 抑制剂Vorasidenib (AG-881)是一种有效且选择性的口服抑制剂，可抑制细胞质中异柠檬酸脱氢酶1型(IDH1，IDH1 [NADP+]可溶)和2型（IDH2异柠檬酸脱氢酶[NADP+]）的突变形式。线粒体中的线粒体，具有潜在的抗肿瘤活性。 了解更多 -
BAY-1436032
Catalog No. A17059 -
Olutasidenib (FT-2102)
Catalog No. A18789 IDH1 inhibitorOlutasidenib is a potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 for the treatment of acute myeloid leukemia. 了解更多 -
Mutant IDH1-IN-4
Catalog No. A19106 IDH1 inhibitorMutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ?? 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells. 了解更多 -
IDH1 Inhibitor 2
Catalog No. A18420 IDH1 inhibitorDH1 Inhibitor 2 is a potent IDH1 inhibitor via a direct covalent modification of His315, with an IC50 of 110 nM. 了解更多 -
Epacadostat (INCB024360)
Catalog No. A15554 IDO 抑制剂Epacadostat (INCB024360)是一种有效的选择性吲哚胺2,3-二加氧酶（IDO1）抑制剂，第2期的IC50为10 nM。 了解更多 -
IDO/TDO-IN-1
Catalog No. A18566 IDO/TDO dual inhibitorIDO/TDO-IN-1 is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively . 了解更多 -
GNF-PF-3777
Catalog No. A13507 hIDO2 inhibitorGNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM. 了解更多 -
IACS-8968 R-enantiomer
Catalog No. A21555 dual IDO/TDO inhibitorIACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 了解更多 -
IACS-8968 S-enantiomer
Catalog No. A21559 dual IDO/TDO inhibitorIACS-8968 (S-enantiomer) is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 了解更多 -
INCB024360 analog
Catalog No. A13004 -
Indoximod (NLG-8189)
Catalog No. A14397 -
NLG919
Catalog No. A14322 -
BMS-986205
Catalog No. A17013 IDO1 抑制剂BMS-986205，也称为Linrodostat，ONO-7701和F001287，一种有效且选择性的口服IDO1抑制剂，具有潜在的免疫调节和抗肿瘤活性。 了解更多 -
Bexarotene (LGD1069)
Catalog No. A11094 Retinoid X Receptor LigandBexarotene (LGD1069)是一种高度选择性的类维生素A X受体（RXR）激动剂。 了解更多 -
Adarotene (ST1926)
Catalog No. A11298 Adarotene (ST1926)Adarotene 是一种有效的 apoptosis 诱导剂，通过产生 DNA 损伤，来阻止人类肿瘤细胞的增殖。 了解更多 -
Fenretinide
Catalog No. A12163 -
LG 100268
Catalog No. A14127 -
Tretinoin
Catalog No. A10944 -
Tamibarotene
Catalog No. A11589 RARα 激动剂Tamibarotene是一种是视黄酸受体α/β (RARα/β)的激动剂，在体外可诱导HL-60细胞分化（ED50 = 0.79 nM）和凋亡。 了解更多 -
AGN 194310
Catalog No. A16292 -
AGN 195183
Catalog No. A16293 -
AGN 196996
Catalog No. A16294 RARα 拮抗剂AGN 196996是一种有效的选择性RARα拮抗剂，Ki值为2 nM。对RARβ（Ki = 1087 nM）和RARγ（Ki = 8523 nM）的结合亲和力很小。 了解更多 -
AGN 205327
Catalog No. A16295 -
AGN 205728
Catalog No. A16296
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- 分类
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- Cytochrome P450 (59)
- PPAR (47)
- PDE (74)
- HSP (47)
- Hydroxylases (14)
- Factor Xa (17)
- MAO (30)
- DHFR (10)
- Dehydrogenases (27)
- Procollagen C-proteinase (1)
- Carbonic Anhydrase (12)
- LXR (13)
- FAAH (11)
- 15-PGDH (2)
- CETP (6)
- Ferroptosis (5)
- HMG-CoA Reductase (15)
- FXR (14)
- Isocitrate Dehydrogenase (IDH) (14)
- IDO (13)
- Retinoid Receptor (22)
- Lipase (12)
- Phospholipases (13)
- Lipoxygenase (13)
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- Fatty acid synthase (FASN) (7)
- Glucokinase (3)
- Lactate dehydrogenase A (LDHA) (1)
- Oxidative Phosphorylation (3)
- PFKFB3 (3)
- Ribonucleotide Reductase (2)
- Acetyl-CoA Carboxylase (6)
- Glucosidase (12)
- Phosphatase (6)
- 作用机制
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- Inhibitor (抑制剂) (394)
- Agonist (激动剂) (66)
- Antagonist (拮抗剂) (22)
- Activator (激活剂) (11)
- Modulator (调节剂) (2)
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- Inducer (诱导剂) (5)
- Substrate (底物) (4)
- 靶点
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- 5-lipoxygenase (1)
- Carbonic Anhydrase (6)
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- Carbonic Anhydrase II (3)
- Carbonic Anhydrase IV (2)
- Carbonic Anhydrase IX (2)
- CETP (4)
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- FTase (4)
- HDAC1 (1)
- HMG-CoA Reductase (9)
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