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￥ 0.00 GSK-3
| Catalog No. | Inhibitor Name | GSK-3 | GSK-3α | GSK-3β | Other Targets |
|---|---|---|---|---|---|
| A10825 | SB216763 | ** | ** | ||
| A11085 | CHIR-98014 | **** | **** | Cdc2 | |
| A11223 | TWS119 | ** | |||
| A11592 | Tideglusib | * | |||
| A11061 | SB415286 | * | * | ||
| A10199 | CHIR-99021 | *** | **** | ||
| A13060 | AZD2858 | * | |||
| A12819 | AZD1080 | *** | ** | ||
| A13728 | AR-A014418 | ** | |||
| A11941 | TDZD-8 | * | |||
| A12741 | LY2090314 | **** | **** | ||
| A15555 | BIO-acetoxime | *** | *** | ||
| A14196 | IM-12 | ** | |||
| A10471 | Indirubin | * | CDK2/CyclinA,CDK5/p35,CDK1/CyclinB | ||
| A15526 | Bikinin | ||||
| A14303 | 1-Azakenpaullone | ||||
| A16280 | Indirubin-3-monoxime | *** | CDK1/5 | ||
| A16230 | CP21R7 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
25 个项目
每页
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GSK-3 inhibitor 1
Catalog No. A21803 -
VP3.15 dihydrobromide
Catalog No. A21789 PDE7/GSK3 inhibitorVP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多 -
CHIR-99021 trihydrochloride
Catalog No. A21436 GSK-3α/β inhibitorCHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM. 了解更多 -
CHIR-99021 monohydrochloride
Catalog No. A21430 GSK-3α/β inhibitorCHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. 了解更多 -
VP3.15
Catalog No. A18538 dual PDE7/GSK-3 inhibitorVP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多 -
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最新产品
BIO
Catalog No. A17129 -
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Bikinin
Catalog No. A15526 -
IM-12
Catalog No. A14196 -
1-Azakenpaullone
Catalog No. A14303 GSK-3β 抑制剂1-Azakenpaullone是一种有效的选择性GSK-3β抑制剂，IC50为18 nM，选择性比CDK1/cyclin B和CDK5/p25高100倍。 了解更多 -
AZD2858
Catalog No. A13060 -
Tideglusib
Catalog No. A11592 GSK-3 抑制剂Tideglusib是一种不可逆的，非ATP竞争性的GSK-3β抑制剂，无细胞试验中IC50为60 nM。用于治疗阿尔茨海默氏病和进行性核上性麻痹。 了解更多 -
TWS119
Catalog No. A11223 -
CHIR-98014
Catalog No. A11085 -
AR-A 014418
Catalog No. A13728 GSK-3 抑制剂AR-A 014418是一种选择性糖原合酶激酶3 (GSK-3) 抑制剂 (IC50 = 104 nM)。对GSK-3的特异性超过cdk2和cdk5（IC50值> 100μM）以及26种其他激酶。抑制β-淀粉样蛋白介导的海马片神经变性。 了解更多 -
BIO-acetoxime
Catalog No. A15555 GSK-3 抑制剂BIO-acetoxime是一种有效的双重GSK3α/β抑制剂，IC50为10 nM，选择性比CDK5/p25，CDK2/cyclin A和 CDK1/cyclin B高240倍以上。 了解更多 -
Indirubin-3-monoxime
Catalog No. A16280 GSK-3β 抑制剂Indirubin-3'-monoxime是一种功能强大的GSK-3β抑制剂，IC50为22nM，也抑制CDK1/5（IC50 = 180/100 nM）。 了解更多
25 个项目
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