PDE

Catalog No.Inhibitor Name PDEPDE1PDE2PDE3PDE4PDE5PDE6PDE9APDE10AOther
A10804Roflumilast
****
A10216Cilomilast
***
A10883Tadalafil
***
A10733Pimobendan
**
A11073GSK256066
****
A11191PF-2545920
****
A10805Rolipram
**
A10217Cilostazol
**
A10592Milrinone
**
**
ATPase
A12619Avanafil
****
A10066Aminophylline
*
adenosine receptor
A15799TAK-063
****
A13722Deltarasin
***
A10541Luteolin
*
*
*
*
*
A10464Icariin
**
mAChR,AChR
A10480Irsogladine
A10319Dipyridamole
A10339Dyphylline
A11527PF-8380
***
A10965Vardenafil
***
****
A11019Ibudilast (KC-404)
A11289Apremilast (CC 10004)
***
A11326Bay 60-7550
****
A11602Vinpocetine
Sodium channel
A12550Zardaverine
**
**
A12631Sildenafil
***
***
A12776AN2728
***
A13121PF-04447943
***
A13467MK-0359
A13596Cilostamide
***
A15191Nortadalafil
A15197Oglemilast
****
A15198Olprinone Hydrochloride

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 71个

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  1. Sildenafil

    Catalog No. A12631
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    PDE5 抑制剂
    Sildenafil是选择性磷酸二酯酶5(PDE5)抑制剂之一(IC50 = 5.22 nM),被认为是治疗勃起功能障碍的最佳方法。 了解更多
  2. TAK-063

    Catalog No. A15799
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    PDE10A 抑制剂?
    TAK-063是一种高效,选择性和口服活性的PDE10A抑制剂,IC50为0.30 nM。选择性是其他PDE的15000倍以上。 了解更多
  3. Olprinone Hydrochloride

    Catalog No. A15198
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    PDE3 抑制剂
    Olprinone Hydrochloride是一种选择性磷酸二酯酶3(PDE3)抑制剂。 了解更多
  4. Oglemilast

    Catalog No. A15197
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    PDE4 抑制剂
    Oglemilast是PDE4的有效抑制剂。 了解更多
  5. Nortadalafil

    Catalog No. A15191
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    PDE5 抑制剂
    Nortadalafil是去甲基他达拉非,它是一种PDE5抑制剂,目前以药丸形式销售,用于治疗勃起功能障碍(ED),名称为Cialis。并以Adcirca为名,用于治疗肺动脉高压。 了解更多
  6. GSK256066 2,2,2-trifluoroacetic acid

    Catalog No. A15097
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    PDE 抑制剂
    GSK256066是一种选择性PDE4B(与A-D型同等亲和力)抑制剂,IC50为3.2 pM,对PDE1/2/3/5/6的选择性> 380,000倍,对PDE4B与PDE7的选择性> 2500倍。 了解更多
  7. MK-0359

    Catalog No. A13467
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    PDE4 抑制剂
    MK-0359是一种选择性和有效的口服PDE4抑制剂,用于慢性哮喘。 了解更多
  8. Cilostamide

    Catalog No. A13596
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    PDE3 抑制剂
    Cilostamide是磷酸二酯酶(PDE)3A和PDE3B的选择性抑制剂,IC50值分别为27和50 nM。 了解更多
  9. Vinpocetine

    Catalog No. A11602
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    PDE1 抑制剂
    Vinpocetine是一种Ca2+钙调蛋白依赖性磷酸二酯酶I(PDE1)抑制剂。 了解更多
  10. PDE-9 inhibitor

    Catalog No. A11532
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    PDE-9 inhibitor
    PDE-9 inhibitor is useful for neurodegenerative diseases. 了解更多
  11. AN3199

    Catalog No. A12228
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    PDE4 inhibitor
    AN3199 is a PDE4 inhibitor with IC50 of 94.5 nM. 了解更多
  12. PF-05180999

    Catalog No. A13006
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    PDE2A inhibitor
    PF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC50 of 1.6 nM. 了解更多
  13. BI-409306

    Catalog No. A12970
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    PDE9A inhibitor
    BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM. 了解更多
  14. Sildenafil citrate

    Catalog No. A10841
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    PDE5 inhibitor
    Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM. 了解更多
  15. Mirodenafil dihydrochloride

    Catalog No. A18047
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    PDE-5 inhibitor
    Mirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. 了解更多
  16. Deltasonamide 2 (TFA)

    Catalog No. A21979
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    PDEδ inhibitor
    Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. 了解更多
  17. Deltasonamide 2

    Catalog No. A21970
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    PDEδ inhibitor
    Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. 了解更多
  18. ITI214 free base

    Catalog No. A21947
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    picomolar PDE1 inhibitor
    ITI-214 (free base) is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). 了解更多
  19. TP-10

    Catalog No. A21935
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    PDE10A inhibitor
    TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. 了解更多
  20. Olprinone

    Catalog No. A21869
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    PDE3 inhibitor
    Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. 了解更多
  21. IBMX

    Catalog No. A21847
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    PDE inhibitor
    IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively. 了解更多
  22. VP3.15 dihydrobromide

    Catalog No. A21789
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    PDE7/GSK3 inhibitor
    VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多
  23. BAY 73-6691 racemate

    Catalog No. A21745
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    PDE9 inhibitor
    BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor extracted from patent WO 2017070293 A1. 了解更多
  24. AMG 579

    Catalog No. A21478
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    PDE10A inhibitor
    AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. 了解更多
  25. ITI214

    Catalog No. A21422
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    PDE1 inhibitor
    ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). 了解更多
  26. Saterinone hydrochloride

    Catalog No. A21402
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    PDE3 inhibitor
    Saterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor. 了解更多
  27. Mirodenafil

    Catalog No. A21260
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    PDE-5 inhibitor
    Mirodenafil(SK3530) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. 了解更多
  28. D159687

    Catalog No. A21228
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    PDE4D inhibitor
    D159687 is a selective PDE4D inhibitor. 了解更多
  29. PF-04957325

    Catalog No. A21246
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    PDE8 inhibitor
    PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. 了解更多
  30. Roflumilast N-oxide

    Catalog No. A16984
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    PDE4 抑制剂
    Roflumilast N-oxide是罗氟司特的活性代谢产物。Roflumilast N-oxide是磷酸二酯酶4抑制剂。 了解更多
  31. Ademetionine

    Catalog No. A17531
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    PDE4B inhibitor
    Ademetionine, also known as AdoMet; MSI-195; SAMe, S-adenosylmethionine, is a PDE4B inhibitor potentially for treatment of primary biliary cirrhosis and major depressive disorder. 了解更多
  32. Lodenafil

    Catalog No. A18029
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    PDE5 inhibitor
    Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED). 了解更多
  33. Fosphenytoin disodium

    Catalog No. A18184
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    PDE3 inhibitor
    Fosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin. It is an PDE3 (phosphodiesterase 3) inhibitor. 了解更多
  34. CM-675

    Catalog No. A18741
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    PDE5/HDAC-1 inhibitor
    CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. 了解更多
  35. BPN14770

    Catalog No. A18663
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    PDE4D inhibitor
    BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. 了解更多
  36. MT-3014

    Catalog No. A18580
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    PDE 10A inhibitor
    MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively. 了解更多
  37. PDE12-IN-3

    Catalog No. A18579
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    PDE12 inhibitor
    PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity. 了解更多
  38. R 80123

    Catalog No. A21836
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    phosphodiesterase inhibitor
    R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. 了解更多
  39. PF-05085727

    Catalog No. A20098
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    PDE2A inhibitor
    PF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM. 了解更多
  40. VP3.15

    Catalog No. A18538
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    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多
  41. TPN171

    Catalog No. A18464
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    PDE5 inhibitor
    TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. 了解更多
  42. Cilostazol

    Catalog No. A10217
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    PDE3 抑制剂
    Cilostazol是3型磷酸二酯酶(PDE3)的选择性抑制剂,IC50为0.2 μM,其治疗重点是cAMP。 了解更多
  43. Rolipram

    Catalog No. A10805
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    PDE4 抑制剂
    Rolipram是一种PDE4抑制剂,IC50 = 2.0μM。 了解更多
  44. Icariin

    Catalog No. A10464
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    PDE5 抑制剂
    Icariin对抑制PDE5A1、PDE5A2和PDE5A3的所有三种PDE5A亚型均有抑制作用,IC50值分别为1.0、0.75和1.1 μM。 了解更多
  45. Pimobendan (Vetmedin)

    Catalog No. A10733
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    PDE 抑制剂
    Pimobendan (Vetmedin)是一种钙增敏剂,具有正性肌力和血管舒张作用。它也是磷酸二酯酶III(PDE3)的选择性抑制剂。 了解更多
  46. GSK256066

    Catalog No. A11073
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    PDE 抑制剂
    GSK256066是PDE4的极高亲和力和选择性抑制剂,它以相等的亲和力抑制PDE4亚型A-D,并具有很高的HARBS(高亲和力利普兰结合位点)比率(> 17)。 了解更多
  47. PF-2545920

    Catalog No. A11191
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    PDE10A 抑制剂
    PF-2545920是对PDE10A亚型具有选择性的磷酸二酯酶抑制剂。 了解更多
  48. Ibudilast (KC-404)

    Catalog No. A11019
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    PDE 抑制剂
    Ibudilast (KC-404)是一种相对非选择性的phosphodiesterase抑制剂,具有抗炎和神经保护活性。 了解更多
  49. Cilomilast (SB-207499)

    Catalog No. A10216
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    PDE-4 抑制剂
    Cilomilast (SB-207499)可作为选择性磷酸二酯酶4抑制剂,具有抗炎作用。可针对与COPD相关的支气管收缩,粘液分泌过多和气道重塑。 了解更多
  50. Hesperetin

    Catalog No. A10449
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    PDE4 抑制剂
    Hesperetin是一种选择性磷酸二酯酶(PDE)4抑制剂,存在于中药“陈皮”中。橙皮素是一种柑橘类黄酮,据报道可以降低血浆胆固醇。橙皮素降低Hep-G2细胞中ACAT-2 mRNA的转录,并以剂量依赖的方式降低ApoB蛋白的合成。它也是类癌的潜在疗法。 了解更多

产品 1 到 50 共 71个

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