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Stem Cells / Wnt

产品 101 到 130 共 130个

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  1. IWP-4
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    IWP-4

    Catalog No. A17004
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    Wnt/β-catenin signaling 抑制剂
    IWP-4是Wnt /β-catenin信号传导的新型有效抑制剂。 了解更多
  2. pyrvinium
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    pyrvinium

    Catalog No. A17784
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    Wnt 抑制剂
    Pyrvinium pamoate is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling. 了解更多
  3. Wnt/β-catenin agonist 1
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    Wnt/β-catenin agonist 1

    Catalog No. A18689
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    Wnt/β-catenin 激动剂
    Wnt/β-catenin agonist 1 is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM. 了解更多
  4. HLY78
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    HLY78

    Catalog No. A18402
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    Wnt/β-catenin 激活剂
    HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. 了解更多
  5. SKL2001
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    SKL2001

    Catalog No. A16707
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    Wnt/β-catenin agonist
    SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction. 了解更多
  6. Longdaysin
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    Longdaysin

    Catalog No. A21022
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    Wnt/??-catenin signaling inhibitor
    Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. 了解更多
  7. IWP-3
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    IWP-3

    Catalog No. A13192
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    Wnt 抑制剂
    IWP-3是Wnt产生的抑制剂。在体外阻断Wnt途径的活性（IC 50 = 40 nM）。IWP-3使豪猪（Porcn）失活，豪猪（Porcn）是一种膜结合的O-酰基转移酶，负责棕榈酸化Wnt蛋白，这对于其信号传导能力和分泌至关重要。通过阻断Wnt信号传导，IWP-3已被用于促进人类胚胎干细胞（EC??= 1.2μM）产生心肌细胞。 了解更多
  8. BML-284 (Wnt agonist 1)
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    BML-284 (Wnt agonist 1)

    Catalog No. A15851
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    Wnt 激动剂 1
    BML-284 (Wnt agonist 1)是细胞可渗透的Wnt信号传导活化剂。它诱导β-catenin和TCF依赖性转录活性，EC50值为0.7 uM。 了解更多
  9. ETC-159
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    ETC-159

    Catalog No. A15840
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    Wnt 抑制剂
    ETC-159是Wnt分泌的有效和特异性抑制剂。ETC-159以剂量依赖性方式抑制β-catenin报告基因的活性，IC50为2.9 nM。 了解更多
  10. IQ-1
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    IQ-1

    Catalog No. A16064
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    Wnt/beta-catenin 抑制剂
    IQ-1是可透过细胞的四氢异喹啉亚基化合物，可调节Wnt/β-catenin信号传导。 了解更多
  11. WAY-262611
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    WAY-262611

    Catalog No. A16094
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    Wnt pathway activator
    WAY-262611是一种无翼β-连环蛋白激动剂，可增加骨形成速率；在TCF-荧光素酶测定中的EC50为0.63 uM。 了解更多
  12. CCT251545
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    CCT251545

    Catalog No. A16216
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    Wnt 抑制剂
    CCT251545是口服有效的WNT信号抑制剂，IC50值为5 nM。 了解更多
  13. Hexachlorophene
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    Hexachlorophene

    Catalog No. A16217
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    Wnt/beta-catenin 抑制剂
    Hexachlorophene是一种有效的KCNQ1/KCNE1钾通道激活剂，EC50为4.61±1.29 uM。也是Wnt/β-catenin信号的抑制剂。 了解更多
  14. JW74
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    JW74

    Catalog No. A16219
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    Wnt 抑制剂
    JW74是典型的Wnt信号传导的有效和特异性抑制剂。JW74显示ST-Luc分析中规范Wnt信号的减少，IC50值为790 nM。 了解更多
  15. GDC-0449 (Vismodegib)
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    GDC-0449 (Vismodegib)

    Catalog No. A10258
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    Hedgehog 拮抗剂
    GDC-0449 (Vismodegib)是一种新型有效的，特异性hedgehog抑制剂，IC50为3 nM。 了解更多
  16. Cyclopamine
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    Cyclopamine

    Catalog No. A10249
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    Hedgehog signaling 抑制剂
    Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂，作用于Smoothened (Smo)，IC50为46 nM。Cyclopamine 抑制Hedgehog信号通路， IC50 为46 nM。 了解更多
  17. LY2940680 (Taladegib)
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    LY2940680 (Taladegib)

    Catalog No. A11048
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    SMO 拮抗剂
    LY2940680 (Taladegib)已显示可影响由Hedgehog（Hh）蛋白引发的癌细胞信号通路。 了解更多
  18. TAK-441
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    TAK-441

    Catalog No. A11351
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    Hedgehog 抑制剂
    TAK-441是吡咯并[3，2-c]吡啶衍生物，作为高效口服活性hedgehog信号抑制剂。 了解更多
  19. SANT-1
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    SANT-1

    Catalog No. A13095
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    Sonic hedgehog 抑制剂
    SANT-1是有效的细胞渗透性Sonic刺猬（Shh）信号传导抑制剂；平滑活性的高亲和力拮抗剂（KD = 1.2 nM）。以20 nM的IC50抑制平滑的激动剂作用（在Shh-LIGHT2细胞中）。 了解更多
  20. GANT61
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    GANT61

    Catalog No. A13252
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    GLI 拮抗剂
    GANT61是GLI1和GLI2诱导的转录的抑制剂，以5μM的IC50抑制hedgehog，对其他途径（例如TNF和糖皮质激素受体基因反式激活）表现出选择性。 了解更多
  21. GANT 58
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    GANT 58

    Catalog No. A11442
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    GLI 拮抗剂
    GANT 58是有效的Gli拮抗剂，可抑制GLI1诱导的转录，IC50为5 μM。 了解更多
  22. Hh-Ag1.5
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    Hh-Ag1.5

    Catalog No. A12920
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    Hedgehog 抑制剂
    Hh-Ag1.5是Hedgehog途径中最有效，选择性最强的小分子激动剂之一，靶向EC50?1 nM的平滑（Smo）。 了解更多
  23. JK 184
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    JK 184

    Catalog No. A12925
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    Hedgehog 抑制剂
    JK 184是有效的下游hedgehog (Hh)信号抑制剂，可防止Gli依赖性转录活性(IC50 = 30 nM)。 了解更多
  24. HhAntag
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    HhAntag

    Catalog No. A12418
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    HhAntag是GLI1介导的转录的小分子抑制剂，GLI1介导的转录是Hedgehog（Hh）途径的重要下游元素。 了解更多
  25. MK-4101
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    MK-4101

    Catalog No. A16111
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    Hedgehog 抑制剂
    MK-4101是Hedgehog通路的有效和选择性抑制剂。 了解更多
  26. RU-SKI 43
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    RU-SKI 43

    Catalog No. A16229
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    Hhat 抑制剂
    RU-SKI 43是Hhat（刺猬酰基转移酶）的小分子抑制剂，该酶负责将棕榈酸酯附着到Shh上。 了解更多
  27. HPI-4
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    HPI-4

    Catalog No. A16349
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    hedgehog 抑制剂
    HPI-4是一种刺猬（Hh）信号通路抑制剂，中位抑制浓度（IC50）小于10μM。 了解更多
  28. Purmorphamine
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    Purmorphamine

    Catalog No. A11480
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    Hedgehog signaling activator
    Purmorphamine是一种2，6，9-三取代嘌呤，可促进人和小鼠间充质祖细胞向成骨细胞的分化。 了解更多
  29. U18666A
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    U18666A

    Catalog No. A20195
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    cholesterol synthesis/Hedgehog inhibitor
    U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. 了解更多
  30. Mebendazole
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    Mebendazole

    Catalog No. A16606
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    Hedgehog inhibitor
    Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor. 了解更多

产品 101 到 130 共 130个

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分类
  1. Hedgehog (16)
  2. Wnt (28)
  3. β-catenin (18)
  4. Casein Kinase (14)
  5. Smoothened (7)
  6. GSK-3 (25)
  7. Hippo (2)
  8. γ-Secretase (34)
作用机制
  1. Inhibitor (抑制剂) (102)
  2. Agonist (激动剂) (4)
  3. Antagonist (拮抗剂) (6)
  4. Activator (激活剂) (3)
  5. Modulator (调节剂) (10)
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