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PARP1 抑制剂

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产品目录号: A10019


产品名 目录号 价格 数量
A-966492 5mg A10019-5
¥ 900.00
A-966492 10mg A10019-10
¥ 1,600.00
A-966492 50mg A10019-50
¥ 4,500.00
A-966492 100mg A10019-100
¥ 7,500.00
A-966492 10mM * 1mL in DMSO A10019-10mM-D
¥ 1,170.00



A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10019
Mechanism of action Inhibitor
分子量 324.4
化学分子式 C18H17FN4O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 934162-61-5
Synonyms A966492
SMILES code C1CC(NC1)C2=CC(=C(C=C2)C3=NC4=C(C=CC=C4N3)C(=O)N)F
化学名称 2-[2-Fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamide


A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.
1 nM(Ki)1 nM(EC50)1.5 nM(Ki)


Solubility (25°C)* In vitro DMSO 65 mg/mL (200.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.83 mL 154.13 mL 308.26mL
0.5 mM 6.17 mL 30.83 mL 61.65 mL
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL

*The above data is based on the productmolecular weight 324.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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