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AG-014699 (Rucaparib)


PARP 抑制剂

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产品目录号: A10045


产品名 目录号 价格 数量
AG-014699 5mg A10045-5
¥ 600.00
AG-014699 25mg A10045-25
¥ 2,200.00
AG-014699 50mg A10045-50
¥ 3,500.00
AG-014699 100mg A10045-100
¥ 5,800.00
AG-014699 10mM * 1mL in DMSO A10045-10mM-D
¥ 1,100.00



AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.

AG-014699 (Rucaparib)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AG-014699 (Rucaparib) 发表的文献 (1)
  • Tahira Baloch, .et al. Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1, BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446

Chemical Information

目录号 A10045
Mechanism of action Inhibitor
分子量 421.4
化学分子式 C19H18FN3O.H3PO4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 459868-92-9
Synonyms AG014699, PF-01367338,AG-014447 (as free base)
SMILES code CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O
化学名称 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate


AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.
PARP (Cell-free assay)
1.4 nM(Ki)


Solubility (25°C) * In vitro DMSO 84 mg/mL (199.35 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.73 mL 118.65 mL 237.3mL
0.5 mM 4.75 mL 23.73 mL 47.46 mL
1 mM 2.37 mL 11.87 mL 23.73 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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