AG-014699 (Rucaparib)

目录号: A10045

PARP 抑制剂

AG-014699 (Rucaparib)

AG-014699 (Rucaparib) Chemical Structure

CAS NO. 459868-92-9

AG-014699 (Rucaparib)是一种PARP抑制剂,可抑制聚(ADP-核糖)聚合酶(PARP,后者是DNA修复中的关键酶。 无细胞试验中作用于PARP1的Ki为1.4 nM,对其余8个PARP位点也有结合亲和力。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
25 mg
¥ 2,200.00
50 mg
¥ 2,700.00
100 mg
¥ 4,220.00
10mM * 1mL in DMSO
¥ 1,100.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

AG-014699 (Rucaparib)是一种PARP抑制剂,可抑制聚(ADP-核糖)聚合酶(PARP,后者是DNA修复中的关键酶。 无细胞试验中作用于PARP1的Ki为1.4 nM,对其余8个PARP位点也有结合亲和力。
靶点信息
PARP (Cell-free assay)
1.4 nM(Ki)
In vitro (25°C) DMSO 84 mg/mL (199.35 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.73 mL 118.65 mL 237.3 mL
0.5 mM 4.75 mL 23.73 mL 47.46 mL
1 mM 2.37 mL 11.87 mL 23.73 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10045
作用机制 Inhibitor (抑制剂)
M. Wt 421.4
Formula C19H18FN3O.H3PO4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 459868-92-9
Synonyms AG014699, PF-01367338,AG-014447 (as free base)
SMILES CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O

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