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ME0328

PARP3 抑制剂

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产品目录号: A14309

库存状态:中国现货中国现货

产品名 目录号 价格 数量
ME0328 25mg A14309-25
¥ 1,200.00
ME0328 50mg A14309-50
¥ 1,800.00
ME0328 100mg A14309-100
¥ 3,290.00
ME0328 10mM * 1mL in DMSO A14309-10mM-D
¥ 500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.

ME0328

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Chemical Information

目录号 A14309
Mechanism of action Inhibitor
分子量 321.37
化学分子式 C19H19N3O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1445251-22-8
Synonyms ME 0328
SMILES code C[C@@H](C1=CC=CC=C1)NC(=O)CCC2=NC(=O)C3=CC=CC=C3N2
化学名称 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide

生物活性

Description
ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
Targets
PARP3 PARP1
0.89 μM6.3 μM

溶解性

Solubility (25°C)* In vitro DMSO 64 mg/mL (199.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.12 mL 155.58 mL 311.17mL
0.5 mM 6.22 mL 31.12 mL 62.23 mL
1 mM 3.11 mL 15.56 mL 31.12 mL
5 mM 0.62 mL 3.11 mL 6.22 mL

*The above data is based on the productmolecular weight 321.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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