MK-4827 (Niraparib)

Name: MK-4827 (Niraparib)
SKU: A11026
Price: 350 CNY
Rating: 5 (5 reviews)

目录号: A11026

PARP 抑制剂

5 篇发表文献

MK-4827 是一种新型的、高效的、口服生物利用度高的 PARP-1 和 PARP-2 抑制剂。

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Grouped product items
规格	价格	库存
5mg	¥350.00	现货
10mg	¥525.00	现货
25mg	¥735.00	现货
50mg	¥980.00	现货
100mg	¥1,540.00	现货
200mg	¥2,310.00	现货
500mg	¥3,955.00	现货
*10mM 1mL in DMSO**	¥385.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of MK-4827 (Niraparib)

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用MK-4827 (Niraparib)发表的5篇文献

Joseph M Gozgit, .et al. , Cancer cell, 2021, Jul 22;S1535-6108(21)00340-8 PMID: 34375612

Ann-Katrin Hopp, .et al. , Molecular cell, 2021, Jan 21; 81(2): 340–354 PMID: 33450210

Bian C, .et al. , Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937

Tahira Baloch, .et al. , BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446

Khalid Hilmi, .et al. , Sci Adv, 2017, May; 3(5): e1601898 PMID: 28560323

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生物活性

Discription

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11026
分子式	C19H20N4O
分子量	320.4
CAS号	1038915-60-4
SMILES	C1C[C@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
其他名称	MK4827
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	60 mg/mL (187.27 mM)
	Water	Insoluble
	Ethanol	60 mg/mL (187.27 mM)
In vivo	10% DMSO+40% PEG 300+5% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.21 mL	156.05 mL	312.11 mL
0.5 mM	6.24 mL	31.21 mL	62.42 mL
1 mM	3.12 mL	15.61 mL	31.21 mL
5 mM	0.62 mL	3.12 mL	6.24 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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