Stenoparib (E7449)
目录号: A21553
PARP1/PARP2 抑制剂
E7449 是一种强效的 PARP1 和 PARP2 抑制剂,同时也能抑制 TNKS1 和 TNKS2,其半抑制浓度(IC50)分别为 PARP1 2.0 nM、PARP2 1.0 nM、TNKS1 和 TNKS2 约50 nM,使用的底物为 32P-NAD+。
| Discription | E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. | |||||
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| Cell Research |
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| 目录号 | A21553 |
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| 分子式 | C18H15N5O |
| 分子量 | 317.34 |
| CAS号 | 1140964-99-3 |
| SMILES | O=C1NNC2=C3C1=CC=CC3=NC(CN4CC5=C(C=CC=C5)C4)=N2 |
| 其他名称 | E-7449, E 7449 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2