BMN673

目录号: A11243

PARP 抑制剂

BMN673

BMN673 Chemical Structure

CAS NO. 1207456-01-6

BMN-673是核酶聚(ADP-核糖)聚合酶(PARP)的口服生物利用抑制剂,无细胞试验中对PARP1的IC50为0.57 nM。它也是有效的PARP-2抑制剂,但不抑制PARG,对PTEN突变型高度敏感。具有潜在的抗肿瘤活性。

库存: 现货

规格 价格 数量
5 mg
¥ 650.00
10 mg
¥ 900.00
25 mg
¥ 1,400.00
50 mg
¥ 2,250.00
10mM * 1mL in DMSO
¥ 650.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

BMN-673是核酶聚(ADP-核糖)聚合酶(PARP)的口服生物利用抑制剂,无细胞试验中对PARP1的IC50为0.57 nM。它也是有效的PARP-2抑制剂,但不抑制PARG,对PTEN突变型高度敏感。具有潜在的抗肿瘤活性。
靶点信息
PARP (Cell-free assay)
0.58 nM
In vitro DMSO 76 mg/mL heating (199.81 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.29 mL 131.46 mL 262.92 mL
0.5 mM 5.26 mL 26.29 mL 52.58 mL
1 mM 2.63 mL 13.15 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11243
作用机制 Inhibitor (抑制剂)
M. Wt 380.35
Formula C19H14F2N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1207456-01-6
Synonyms BMN-673, BMN 673
SMILES CN1C(=NC=N1)[C@@H]2[C@H](N=C3C=C(C=C4C3=C2NNC4=O)F)C5=CC=C(C=C5)F

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