Angiogenesis

Angiogenesis is the formation and remodelling of new blood vessels and capillaries from growth of pre-existing blood vessels. It normally occurs during wound healing and embryonic development, but is also required for tumour growth and metastasis in cancer.

产品 401 到 428 共 428个

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  1. Saracatinib (AZD0530)

    Catalog No. A10108
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    Src/Abl 抑制剂
    Saracatinib (AZD0530)是一种高选择性,双特异性Src/Abl激酶抑制剂,对c-Src和Abl激酶的IC50分别为2.7和30 nM。 了解更多
  2. Bafetinib (INNO-406)

    Catalog No. A10119
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    Bcr-Abl 抑制剂
    Bafetinib (INNO-406)是一种双重Bcr-Abl/Lyn酪氨酸激酶抑制剂。 了解更多
  3. Nilotinib (AMN-107)

    Catalog No. A10644
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    Bcr-Abl 抑制剂
    Nilotinib (AMN-107)是一种Bcr-Abl抑制剂,IC50小于30 nM。 了解更多
  4. AT9283

    Catalog No. A10095
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    Aurora/JAK 抑制剂
    AT9283抑制极光激酶A和B,并靶向与骨髓细胞增殖相关的其他酪氨酸和丝氨酸/苏氨酸激酶。 了解更多
  5. NVP-BHG712

    Catalog No. A10661
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    EphB4 抑制剂
    NVP-BHG712是EphB4激酶的选择性抑制剂,在体外对EphB4的选择性超过40多种其他激酶(包括FGFR3)。 了解更多
  6. DCC-2036 (Rebastinib)

    Catalog No. A11200
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    Bcr-Abl 抑制剂
    DCC-2036 (Rebastinib)是一种Bcr-Abl抑制剂,作用于Abl1(WT)和Abl1(T315I),IC50分别为0.8 nM和4 nM,也抑制SRC, LYN, FGR, HCK, KDR, FLT3,和Tie-2,对c-Kit具有低的抑制活性。 了解更多
  7. Dasatinib Monohydrate

    Catalog No. A16320
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    Dasatinib Monohydrate是一种新型,有效且多靶点的抑制剂,靶向Abl,Src和c-Kit,IC50分别<1 nM,0.8 nM和79 nM。 了解更多
  8. GNF-7

    Catalog No. A15887
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    Bcr-Abl 抑制剂
    GNF-7是一种有效的II型激酶Bcr-Abl抑制剂,对于M351T,T315I,E255 V,G250E和c-Abl,IC50分别<5 nM,61 nM,122 nM,136 nM和133 nM。 了解更多
  9. GZD824 Dimesylate

    Catalog No. A15849
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    Bcr-Abl 抑制剂
    GZD824 Dimesylate是Bcr-Abl(WT)和Bcr-Abl(T315I)的新型生物可用Bcr-Abl抑制剂,IC50分别为0.34 nM和0.68 nM。 了解更多
  10. DPH

    Catalog No. A11379
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    c-ABL activitor
    DPH是一种有效的细胞渗透性c-Abl激活剂,在刺激c-Abl激活中显示出强大的酶和细胞活性。 了解更多
  11. Lyn-IN-1

    Catalog No. A16265
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    dual Bcr-Abl/Lyn 抑制剂
    Lyn-IN-1是一种有效的选择性Bcr-Abl/Lyn双重抑制剂,摘自专利WO2014169128A1。 了解更多
  12. ON 146040

    Catalog No. A16266
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    dual PI3K and BCR-ABL 抑制剂
    ON 146040是第一个靶向STAT3和STAT5途径的PI3K和BCR-ABL双重抑制剂;抑制PI3Kα/δ同工型,IC50为14/20 nM。 了解更多
  13. SNIPER(ABL)-062

    Catalog No. A18567
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    ABL inhibitor
    SNIPER(ABL)-062, in which an ABL inhibitor is linked to a ligand of cIAP1 via a linker containing a variable polyethylene glycol (PEG) unit, shows a potent activity to degrade the BCR-ABL protein. 了解更多
  14. CZC-8004

    Catalog No. A19444
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    ABL inhibitor
    CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase. 了解更多
  15. CHMFL-ABL-121

    Catalog No. A19079
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    ABL2 inhibitor
    CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively. 了解更多
  16. CHMFL-ABL-039

    Catalog No. A13182
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    BCR-ABL inhibitor
    CHMFL-ABL-039 is a type II native ABL kinase and drug-resistant V299L mutant BCR-ABL inhibitor with the IC50s of 7.9 nM and 27.9 nM, respectively. CHMFL-ABL-039 is used in the research of chronic myeloid leukemia. 了解更多
  17. BCR-ABL-IN-1

    Catalog No. A12496
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    BCR-ABL inhibitor
    BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia. 了解更多
  18. CHMFL-ABL/KIT-155

    Catalog No. A12421
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    ABL/c-KIT dual kinase inhibitor
    CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor. 了解更多
  19. 1-Naphthyl PP1 hydrochloride

    Catalog No. A21790
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    Src/c-Abl inhibitor
    1-Naphthyl PP1 hydrochloride is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). 了解更多
  20. BCR-ABL-IN-2

    Catalog No. A21043
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    inhibitor of BCR-ABL1 tyrosine kinase
    BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively. 了解更多
  21. WP1130 (Degrasyn)

    Catalog No. A10988
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    DUB/Bcr/ABL 抑制剂
    WP1130 (Degrasyn)是一种新型的选择性小分子去泛素酶抑制剂和Bcr/Abl破坏途径激活剂,可特异性和快速下调野生型和突变型Bcr/Abl蛋白,而不会影响慢性粒细胞性白血病(CML)中的bcr/abl基因表达细胞。 了解更多
  22. GNF 2

    Catalog No. A11439
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    Bcr-Abl 抑制剂
    GNF 2是一种Bcr-abl抑制剂,在表达Bcr-abl的细胞中抑制增殖并诱导凋亡。 了解更多
  23. PD173955

    Catalog No. A13120
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    Bcr-Abl 抑制剂
    PD-173955是src酪氨酸激酶抑制剂。PD173955抑制Bcr-Abl依赖的细胞生长。PD173955显示G(1)中的细胞周期停滞。PD173955在Bcr-Abl的激酶抑制测定中的IC(50)为1-2 nM,在细胞生长测定中,其抑制Bcr-Abl依赖性底物酪氨酸磷酸化。 PD173955抑制试剂盒配体依赖性c-kit自磷酸化(IC(50)=约25 nM)和试剂盒配体依赖性M07e细胞增殖(IC(50)= 40 nM),但对白介素3依赖性(IC (50)= 250 nM)或粒细胞巨噬细胞集落刺激因子(IC(50)= 1 microM)依赖性细胞生长。 了解更多
  24. GNF-5

    Catalog No. A13237
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    Bcr-Abl 抑制剂
    GNF-5是BCR-ABL的选择性变构抑制剂。 了解更多
  25. NRC-AN-019

    Catalog No. A13562
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    Bcr-Abl 抑制剂
    NRC-AN-019是Bcr-Abl蛋白-酪氨酸激酶的口服酪氨酸激酶抑制剂(TKI)。NRC-AN-019在抑制MDAMB231和HTB20/BT474细胞的血管生成潜力和增殖方面更有效。 了解更多
  26. Nilotinib monohydrochloride monohydrate

    Catalog No. A15186
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    Bcr-Abl 抑制剂
    Nilotinib monohydrochloride monohydrate是一种Bcr-Abl抑制剂,IC50小于30 nM。 了解更多
  27. Radotinib (IY-5511)

    Catalog No. A13029
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    Bcr-Abl tyrosine 抑制剂?
    Radotinib是一种新型的选择性Bcl-Abl酪氨酸激酶抑制剂。 了解更多
  28. GZD824

    Catalog No. A16264
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    Bcr-Abl 抑制剂
    GZD824是一种新型的口服生物利用型抑制剂,可抵抗包括T315I在内的各种Bcr-Abl突变体。 了解更多

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