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Epigenetics | 表观遗传学

产品 101 到 150 共 312个

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Catalog No. Product Name Application Product Information
A11193 SALE


JAK 抑制剂

NVP-BSK805 is a potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor that potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.

A11329 SALE

Baricitinib (LY3009104)

JAK 抑制剂
Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM).
A11795 SALE


JAK 抑制剂
WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation.
A11241 SALE


JAK 抑制剂
BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity.

Go 6976

PKC 抑制剂
Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.
A12694 SALE

Pacritinib (SB1518)

JAK2/FLT3 抑制剂
Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.
A12808 SALE


JAK2 抑制剂
CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM.
A12394 SALE


JAK2 抑制剂
XL019 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity.

PF-03394197 (oclacitinib)

JAK1 抑制剂
PF-03394197 (oclacitinib) is a potent JAK1 inhibitor
A13162 SALE


JAK1 抑制剂
GLPG0634 is an orally-available, selective inhibitor of JAK1 (Janus kinase 1) being developed by Galapagos for the treatment of rheumatoid arthritis and potentially other inflammatory diseases.
A13457 SALE

Pyridone 6 (JAK Inhibitor I)

JAK 抑制剂
JAK Inhibitor I is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1, JAK2, and JAK3.

WHI-P 154

JAK3 抑制剂
WHI-P 154 is a JAK3 inhibitor with IC50 = 1.8uM. WHI-P 154 also Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro.

PRT 062070 (Cerdulatinib)

Dual Syk and JAK 抑制剂
PRT062070 is a novel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types.

NSC 42834(JAK2 Inhibitor V, Z3)

JAK2 抑制剂
Z3 is a novel specific inhibitor of Jak2 tyrosine kinase.
A14210 SALE


multi-targeted tyrosine kinase 抑制剂
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.
A14232 SALE


JAK 抑制剂
Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
A14390 SALE

INCB39110 (Itacitinib)

JAK1 抑制剂
INCB39110 is a potent JAK1 tyrosine kinase inhibitor, which is currently in Phase II trials for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.

Solcitinib (GSK2586184)

JAK1 抑制剂
Solcitinib is a Janus kinase 1 (JAK1) inhibitor.


JAK3 抑制剂
Decernotinib is an oral, selective Janus kinase 3 (JAK3) inhibitor being developed by Vertex.

ZM 39923 HCl

JAK3 抑制剂
ZM 39923 HCl is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 M, respectively)


JAK 抑制剂
S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor.

CYT387 sulfate salt

JAK 抑制剂
CYT387 sulfate salt is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3.
A15134 SALE


JAK3 抑制剂
Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 78 uM); has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases.


JAK2 抑制剂
1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.


Mnk2/JAK3 抑制剂
Cercosporamide, an usnic amide, was originally identified in Cercosporidium henningsii as a host-selective phytotoxin and broad-spectrum antifungal agent and is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2; IC50 = 11 nM), JAK3 (IC50 = 31), and Mnk1 (IC50 = 116 nM).

Cucurbitacin I

JAK2/STAT3 抑制剂
Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells.

SD 1008

JAK2/STAT3 抑制剂
SD 1008 is reported to be a JAK2/STAT3 signaling pathway inhibitor which additionally inhibits Src. SD 1008 is noted to induce apoptosis in cell lines that express constitutively active tyrosine-phosphorylated STAT3.

TCS 21311

JAK3 抑制剂
TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively).

ZM 449829

JAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site.

NSC 33994

JAK2 抑制剂
NSC 33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies.

Baricitinib phosphate

JAK 抑制剂
Baricitinib phosphate is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2.

Peficitinib (ASP015K, JNJ-54781532)

JAK 抑制剂?€?
Peficitinib is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats.


JAK2 抑制剂
FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 uM.


JAK3 抑制剂
WHI-P97 is a rationally designed potent inhibitor of JAK-3.


JAK2 抑制剂
NS-018 is an orally bioavailable, small molecule inhibitor of Janus-associated kinase 2 (JAK2) and Src-family kinases, with potential antineoplastic activity.

NS-018 hydrochloride

JAK2 抑制剂
NS-018 hydrochloride is a novel highly selective JAK2 inhibitor.

NS-018 maleate

JAK2 抑制剂
NS-018 maleate is an ATP-competitive small-molecule inhibitor of JAK2 with IC50 of 470nM in Ba/F3-JAK2V617F cells . have30-50-fold greater selectivity for JAK2 over other JAK-family kinases, such as JAK1, JAK3 and tyrosine kinase 2.


JAK1/3 抑制剂
ZM39923 is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
A11962 SALE

TG-02 (SB1317)

FLT3 抑制剂
TG-02 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor.


JAK2 抑制剂
CHZ868 is a potent and selective type II JAK inhibitor which demonstrates activity in JAK inhibitor persistent cells, murine MPN models, and MPN patient samples.
A10838 SALE

SGI-1776 (free base)

PIM1 抑制剂
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
A11945 SALE


Pim 抑制剂
SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
A13203 SALE


pan-Pim kinase 抑制剂
AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.

TCS PIM-1 4a

Pim 抑制剂
TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively).


Pim 抑制剂
CX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.

CX-6258 HCl

Pan-PIM kinase 抑制剂
CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3.

LGB-321 HCl

Pan-PIM kinase 抑制剂
LGB-321 HCl is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor).

CX-6258 hydrochloride hydrate

Pim 抑制剂
CX-6258 hydrochloride hydrate is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity.

PIM-1 Inhibitor 2

PIM-1 抑制剂
PIM-1 inhibitor 2 is a potent Pim-1 kinase inhibitor (Ki = 91 nM).
A15369 SALE


Pim-1 Kinase 抑制剂
TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).

产品 101 到 150 共 312个

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