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Epigenetics | 表观遗传学



产品 201 到 250 共 312个

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Catalog No. Product Name Application Product Information
A12948 SALE

UNC1215

L3MBTL3 抑制剂
UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity.
A13165 SALE

I-CBP112

CBP/p300 bromodomain 抑制剂
I-CBP112 is a highly potent and selective p300/CBP bromodomain inhibitor (IC50 ~0.14-0.17 uM for CBP and ~0.625 uM for p300).
A13749

MS436

BRD4 抑制剂
MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM.
A15872

I-BRD9

Selective BRD9 抑制剂
I-BRD9 is a potent and selective BRD9 inhibitor with pIC50 of 7.3, while it displayed a pIC50 of 5.3 against BRD4.
A16068

BI-7273

BRD9 BD 抑制剂
BI-7273 is a selective, and cell-permeable BRD9 BD inhibitor.
A16196 SALE

BI-9564

BRD7/9 抑制剂
BI-9564 is a potent and selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 uM, respectively).
A12704

SF1126

Pan PI3K 抑制剂
SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities.
A12815

C646

p300/CBP 抑制剂
C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM).
A14015 SALE

GSK2801

BAZ2A and BAZ2B 抑制剂
GSK2801 is a very potent inhibitor of the BAZ2 family of bromodomain containing proteins
A14160 SALE

(-)-JQ1

BET bromodomain 抑制剂
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes.
A14133 SALE

GSK1324726A

BET 抑制剂
GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), and BRD4 (IC50= 22 nM).
A14134

GSK 525768A

-
GSK 525768A is the enantiomer compound of GSK 525762A, which is a potent small molecule inhibitor that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4); GSK 525768A has NO activity towards BET.
A14226

Anacardic Acid

KAT5 (Tip60), p300/PCAF 抑制剂
Anacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases.
A13957

PFI-3

SMARCA bromodomains probe
PFI-3 is a selective chemical probe for SMARCA bromodomains.
A13956 SALE

RVX-208

BET bromodomain 抑制剂
RVX-208 is a potent BET bromodomain inhibitor with IC50 of 0.510 uM for BD2, about 170-fold selectivity over BD1.
A15367

UNC 926 hydrochloride

MBT Domain (L3MBTL1) 抑制剂
UNC 926 is a methyl lysine reader domain inhibitor.
A13451

PF-4

BRPF1 bromodomain 抑制剂
PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.
A15876

PF-CBP1

CREBBP 抑制剂
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
A15947

BAZ2-ICR

BAZ2 bromodomain 抑制剂
BAZ2-ICR is an excellent chemical probe for functional studies of the BAZ2 bromodomains in vitro and in vivo.
A16000

OF-1

BRPF1B/BRPF2 bromodomain 抑制剂
OF-1 is a chemical probe for BRPF bromodomains. OF-1 has been shown to bind to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 uM (ITC).
A16076

CPI 0610

BET bromodomain 抑制剂
CPI 0610 is a small molecule inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity.
A16092

GSK 5959

BRPF1 bromodomain 抑制剂
GSK 5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.
A16180

EML 425

CBP/p300 抑制剂
EML 425 is a reversible and non-competitive CBP/p300 inhibitor that is cell permeable (IC50 values are 1.1 and 2.9 uM, respectively).
A16330

GSK6853

BRPF1 bromodomain 抑制剂
GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain. shows excellent BRPF1 potency (pKd 9.5) and greater than 1600-fold selectivity over all other bromodomains tested.
A16355

CeMMEC13

TAF1 抑制剂
CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).
A16366

OXF BD 02

BRD4 抑制剂
OXF BD 02, selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC50 = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains.
A16367

GW841819X

BET 抑制剂
GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X was a single enantiomer but of undefined chirality at the 4-position of the benzodiazepine ring 3.
A16368

BET-BAY 002

BET 抑制剂
BET-BAY 002 is a potent BET inhibitor; shows efficacy in a multiple myeloma model.
A16470

CPI-637

CBP/EP300 bromodomain 抑制剂
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
A13246

OG-L002

LSD1 抑制剂
OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.
A13358 SALE

Tranylcypromine hydrochloride

LSD1/BHC110 & MAO 抑制剂
Tranylcypromine hydrochloride is a non-selective MAO-A/B inhibitor.
A12918 SALE

GSK J1

Histone demethylase 抑制剂
GSK J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX
A12927

LSD1-C76

LSD1 抑制剂
LSD1-C76 is a potent and selective Lysine Specific Demethylase-1 (LSD1) inhibitor.
A13806 SALE

JIB-04

Histone Demethylase 抑制剂
JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.
A14277

IOX1

2OG oxygenases 抑制剂
IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.
A14366 SALE

PBIT

JARID1 抑制剂
PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 uM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively).
A15547

GSK2879552

LSD1 抑制剂
GSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
A12732 SALE

GSK-J4

Demethylase 抑制剂
GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release).
A14443 SALE

SP2509 (HCI-2509)

LSD1 抑制剂
SP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B.
A15829

ML-324

JMJD2 抑制剂?€?
ML-324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.
A15893

ORY-1001 (RG-6016)

LSD1 抑制剂
ORY-1001 is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.
A12734

CBB1003

LSD1 抑制剂
CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM.
A16177

CPI 4203

KDM5 demethylases 抑制剂
CPI 4203 is a selective inhibitor of KDM5 demethylases, structurally related to CPI 455 but ~25-fold less potent (IC50 value 250 nM for inhibition of full length KDM5A).
A16178

CPI 455

KDM5 抑制剂
CPI 455 possesses the target specificity required for an in vitro tool compound for exploring KDM5-dependent disease biology, including drug tolerance.
A16371

AS8351

KDM5 抑制剂.
AS8351 is a histone demethylase inhibitor.
A16372

2,4-Pyridinedicarboxylic Acid

KDM 抑制剂
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of histone lysine-specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1.4 μM), KDM5B (IC50, 3 μM), KDM6A and other 2-oxogynases.
A16373

TC-E 5002

KDM2/7 抑制剂
TC-E 5002, selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 uM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.
A16374

CBB1007

LSD1 抑制剂
CBB1007 is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1).
A12785 SALE

Lomeguatrib

MGMT 抑制剂
Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase.
A10005 SALE

(-)-Epigallocatechin gallate

Antioxidant, antiangiogenic, antitumor agent
(-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea.

产品 201 到 250 共 312个

每页
页面:
  1. 3
  2. 4
  3. 5
  4. 6
  5. 7

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