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Epigenetics | 表观遗传学



产品 51 到 100 共 312个

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Catalog No. Product Name Application Product Information
A14236

Santacruzamate A

HDAC 抑制剂
Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs.
A14341 SALE

LMK-235

HDAC4/5 抑制剂
LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor.
A14418

ST7612AA1

HDAC 抑制剂
ST7612AA1 is a new and potent HDAC inhibitor with potential anticancer activity.
A14354 SALE

4SC-202

HDAC 抑制剂
4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity.
A14326

TMP 195

HDAC 抑制剂
TMP195 is the most potent and selective class IIa HDAC inhibitor.
A15781

UF010

HADC 抑制剂
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 uM, 0.1 uM, 0.5 uM and 1.5 uM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.
A13405

HDAC inhibitor

HDAC 抑制剂
N/A
A13731 SALE

JW 55

TNKS1/2 抑制剂
JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2).
A15370

4-HQN

PARP 抑制剂
4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins.
A15371

BYK 204165

PARP-1 抑制剂
BYK204165 is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1).
A15372

BYK 49187

PARP-1/PARP-2 抑制剂
BYK 49187, PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively).
A15373

DR 2313

PARP 抑制剂
PARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor.
A15374

EB 47

PARP1 抑制剂
EB 47 is a potent inhibitor of PARP1 with IC50 of 45 nM.
A15375

NU 1025

PARP 抑制剂
NU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells.
A15528 SALE

G007-LK

TNKS 抑制剂
G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice,
A15786

NVP-TNKS656

TNKS2 抑制剂
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
A15927

MN-64

TNKS 抑制剂
MN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively).
A15873 SALE

AZ6102

TNKS1/2 抑制剂
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.
A10026

ABT-888 (Veliparib)

PARP 抑制剂
ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor.
A10111 SALE

Olaparib (AZD2281)

PARP 抑制剂
Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
A10164 SALE

BSI-201 (Iniparib)

PARP 抑制剂
BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier.
A10045 SALE

AG-014699 (Rucaparib)

PARP 抑制剂
AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.
A10046 SALE

AG14361

PARP 抑制剂
AG14361 is a potent PARP inhibitor, enhanced Temozolomide (TMZ) cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.
A10475

INO-1001

PARP 抑制剂
INO-1001 is a novel PARP inhibitor, known to sensitize cells to radiation in vitro by inhibiting the repair of DNA damage.
A10019 SALE

A-966492

PARP1 抑制剂
A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.
A11026 SALE

MK-4827 (Niraparib)

PARP 抑制剂
MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.
A11243 SALE

BMN673

PARP 抑制剂
BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity.
A12665 SALE

PJ 34 hydrochloride

PARP 抑制剂
PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
A12750 SALE

UPF 1069

PARP2 抑制剂
UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).
A12393 SALE

AZD-2461

PARP 抑制剂
AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein.
A14182 SALE

Rucaparib

PARP-1 抑制剂
Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells.
A14283

WIKI4

Tankyrase 抑制剂
WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2.
A14309

ME0328

PARP3 抑制剂
ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
A14371

Benzamide

PARP-1 抑制剂
Benzamide is the amide derivative of benzoic acid and an inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
A14986

AIM-100

Ack1 (TNK2) 抑制剂
AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM.
A15024

BMN-673 8R,9S

PARP 抑制剂
BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM.
A15215 SALE

PJ34

PARP 抑制剂
PJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM.
A11454

TC-E 5001

TNKS 抑制剂
TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.
A16344

BGP-15

PARP 抑制剂
BGP-15 is a PARP inhibitor, that can protect against heart failure and atrial fibrillation in mice.
A11041

INCB018424 (Ruxolitinib)

JAK1/2 抑制剂
INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;
A10110 SALE

AZD1480

JAK 抑制剂
AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM.
A10095 SALE

AT9283

Aurora/JAK 抑制剂
AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation.
A10546

LY2784544 (Gandotinib)

JAK 抑制剂
LY2784544 is identified as being highly selective for JAK2-V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.
A10047 SALE

AG-490

EGFR 抑制剂
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
A10241 SALE

CP-690550 (Tofacitinib citrate)

JAK3 抑制剂
CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.
A10263 SALE

Cyt387 (Momelotinib)

JAK 抑制剂
CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.
A10247 SALE

Curcumol

JAK2 抑制剂
Curcumol induces apoptosis via caspases-independent mitochondrial pathway in human lung adenocarcinoma ASTC-a-1 cells.
A11082 SALE

TG-101348 (Fedratinib, SAR302503)

JAK2 抑制剂
TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity.
A10104 SALE

AZ-960

JAK2抑制剂
AZ-960 is a potent, selective and ATP competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45 nM in vitro and induces growth arrest and apoptosis in adult T-cell leukemia (ATL) cell.
A11180

TG101209

JAK2 抑制剂

TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

产品 51 到 100 共 312个

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